A5069593286- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Central Venous Catheters and Hemodialysis
- Mechanical Circulatory Support Devices
- Infectious Aortic and Vascular Conditions
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Structural Anomalies and Repair
- Silk-based biomaterials and applications
- Hip and Femur Fractures
- Vascular anomalies and interventions
- Muscle Physiology and Disorders
- Cardiac and Coronary Surgery Techniques
- Colorectal Cancer Screening and Detection
- Cardiovascular and Diving-Related Complications
- Colorectal Cancer Surgical Treatments
- Transplantation: Methods and Outcomes
- Cardiovascular Health and Disease Prevention
- Colorectal and Anal Carcinomas
- Surgical Sutures and Adhesives
- Spine and Intervertebral Disc Pathology
- Cardiac Arrest and Resuscitation
University of North Carolina at Chapel Hill
2024
University of Tennessee at Chattanooga
2023-2024
University Surgical Associates
2024
Duke Medical Center
2015-2021
Washington University in St. Louis
2020-2021
Barnes-Jewish Hospital
2020
Durham VA Medical Center
2019
Duke University
2015-2019
Society of Thoracic Surgeons
2017
Valve (United States)
2017
Mortality rates following acute type A aortic dissection (ATAAD) repair are reduced when operations performed by a high-volume (AAD) team, leading to efforts centralize ATAAD care. Here, we describe our experience with AAD team over the last 10 years, focus on patient selection, transfer protocols, operative approach, and volume trends time.An was implemented at institution in 2005, dedicated surgeons, multidisciplinary approach thoracic disease management, standardized protocol for repair....
Several reports suggest that the efficacy of adjuvant chemotherapy on survival diminishes over time for colon cancer; however, precise timing its loss benefit has not been established.This study aimed to determine relationship between and identify a threshold increased risk mortality.This was retrospective study. Multivariable Cox proportional hazard modeling with restricted cubic splines used evaluate adjusted association overall establish an optimal initiation therapy.Data were collected...
Background The optimal surgical approach for management of acute type A aortic dissection remains controversial. This study aimed to assess outcomes reoperation after repair help guide decision making around index operative strategy. Methods and Results All reoperations (n=129) at a single referral institution from August 2005 April 2016 prior were reviewed. primary outcome was 30‐day or in‐hospital mortality. Secondary included organ‐specific morbidity 1‐ 5‐year as estimated using the...
The impact of hypothermic circulatory arrest (HCA) temperature on postoperative acute kidney injury (AKI) has not been evaluated. This study examined the association between temperatures and AKI in patients undergoing proximal aortic surgery with HCA.A total 759 consecutive who underwent (ascending ± valve root) including arch replacement requiring HCA July 2005 December 2016 were identified from a prospectively maintained institutional database. primary outcome was as defined by Risk,...
Femoral arterial cannulation in adult venoarterial (VA) extracorporeal membrane oxygenation (ECMO) predisposes patients to ipsilateral limb ischemia. Placement of a distal perfusion catheter (DPC) is one few techniques available prevent or manage this complication. Although frequently used, the indications for and timing DPC placement are poorly characterized, no guidelines guide its use. The purpose study was compare incidences vascular complications ischemia between who did not receive at...
Exon skipping has demonstrated great potential for treating Duchenne muscular dystrophy (DMD) and other diseases. We have developed a drug-screening system using C2C12 myoblasts expressing reporter green fluorescent phosphate (GFP), with its reading frame disrupted by the insertion of targeted dystrophin exon. A library 2,000 compounds (Spectrum collection; Microsource Discovery System) was screened to identify drugs capable exons or enhancing exon-skipping effect specific antisense...
Antisense therapy has recently been demonstrated with great potential for targeted exon skipping and restoration of dystrophin production in cultured muscle cells muscles Duchenne Muscular Dystrophy (DMD) patients. Therapeutic values critically depend on efficacy the drugs, antisense oligomers (AOs). However, no animal model established to test AO targeting human vivo systemically. In this study, we applied Vivo-Morpholino hDMD mouse, a transgenic carrying full-length gene, achieved first...
Previous studies have identified risk factors for femoral arterial thrombosis after paediatric cardiac catheterisation, but none of them evaluated the clinical and economic significance this complication at population level. Therefore, we examined national prevalence impact catheterisation in children.Patients⩽18 years age who underwent were 2003-2009 Kids' Inpatient Database. Patients stratified by as follows: <1 year or 1-18 age. The primary outcome was lower extremity during same...
The purpose of this study was to examine whether blood product utilization, one-year cell-mediated rejection rates, and mid-term survival significantly differ for ventricular assist device (VAD patients compared non-VAD (NVAD) following cardiac transplantation.From July 2004 August 2011, 79 underwent transplantation at a single institution. Following exclusion bridged with VADs other than the HeartMate II® LVAD (n = 10), were stratified by VAD presence transplantation: 35, age: 54.0...