A5046082574- Renal and related cancers
- Innovations in Medical Education
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Diversity and Career in Medicine
- Appendicitis Diagnosis and Management
- Renal cell carcinoma treatment
- Sarcoma Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Trauma and Emergency Care Studies
- Mechanical Circulatory Support Devices
- Pancreatic and Hepatic Oncology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Intestinal Malrotation and Obstruction Disorders
- CAR-T cell therapy research
- Central Venous Catheters and Hemodialysis
- Surgical Simulation and Training
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neonatal Respiratory Health Research
- Abdominal Trauma and Injuries
- Hepatocellular Carcinoma Treatment and Prognosis
- Blood Coagulation and Thrombosis Mechanisms
- Cutaneous Melanoma Detection and Management
- Simulation-Based Education in Healthcare
- Mesenchymal stem cell research
University of North Carolina Hospitals
2024-2025
University of North Carolina at Chapel Hill
2024-2025
Duke University
2016-2025
University of North Carolina Health Care
2025
Duke Medical Center
2015-2024
Duke Children's Hospital & Health Center
2022-2024
Cohen Children's Medical Center
2024
University Medical Center
2024
University Hospital and Clinics
2024
Duke University Hospital
2009-2024
Globoid-cell leukodystrophy (GLD) is an inherited demyelinating disease caused by the deficiency of lysosomal enzyme galactosylceramidase (GALC). A previous study in murine model GLD (twitcher) demonstrated a dramatic synergy between CNS-directed adeno-associated virus 2/5 (AAV2/5) gene therapy and myeloreductive bone marrow transplantation (BMT). However, mechanism which these two disparate therapeutic approaches synergize not clear. In addition, efficacy may have been limited since was...
Cerebral palsy (CP) has a significant impact on both patients and society, but therapy is limited. Human umbilical cord blood cells (HUCBC), containing various stem progenitor cells, have been used to treat brain genetic conditions. In small animal experiments, HUCBC improved outcomes after hypoxic-ischemic (HI) injury. Clinical trials using are underway, testing feasibility, safety efficacy for neonatal injury as well CP. We tested in validated rabbit model of CP acute changes secondary HI...
Abstract Background Minimally invasive surgery (MIS) has been widely adopted for common operations in pediatric surgery; however, its role childhood tumors is limited by concerns about oncologic outcomes. We compared open and MIS approaches neuroblastoma Wilms tumor (WT) using a national database. Methods The National Cancer Data Base from 2010 to 2012 was queried cases of WT children ≤21 years old. Children were classified as receiving or definitive resection, with clinical outcomes...
Bleeding and thrombosis in critically ill infants children is a vexing clinical problem. Despite the relatively low incidence of bleeding overall pediatric population relative to adults, these face unique challenges hemostasis due extreme physiologic derangements, exposure blood foreign surfaces membranes, major vascular endothelial injury or disruption. Caring for patients on extracorporeal support, recovering from solid organ transplant invasive surgery, after trauma often complicated by...
Following the publication of recent trials (MSLT-I, MSLT-II, DeCOG), routine completion lymph node dissection (CLND) after positive sentinel biopsy (SLNB) is no longer recommended for adults with melanoma, while adjuvant immunotherapy (IO) was approved selected patients SLNB. Given exclusion pediatric from these studies, we aimed to characterize trends in nodal management Stage III melanoma. The National Cancer Database (NCDB) queried (age ≤20 years) melanoma (clinical I/II; pathologic III)...
Abstract Purpose Improvement in outcomes of LT for pediatric HB and HCC has been reported small series. We analyzed national changes donor, recipient, perioperative factors over time that may contribute to survival differences. Methods The UNOS database was queried patients age <21 years underwent a primary diagnosis or (1987‐2017). Subjects were divided into historic (transplant before 2010) contemporary after cohorts. Baseline characteristics compiled examined. Survival estimated using...
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare tumor for which there are few evidence-based guidelines. The aim this study was to define current management strategies and outcomes these patients using multi-institutional dataset curated by Pediatric Surgical Oncology Research Collaborative.