A5088588258- Central Venous Catheters and Hemodialysis
- Vascular Procedures and Complications
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Infectious Aortic and Vascular Conditions
- Blood Coagulation and Thrombosis Mechanisms
- Dialysis and Renal Disease Management
- Hemostasis and retained surgical items
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Xenotransplantation and immune response
- Cardiac and Coronary Surgery Techniques
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Vascular anomalies and interventions
- Surgical Sutures and Adhesives
- Hemophilia Treatment and Research
- Mechanical Circulatory Support Devices
- Aortic aneurysm repair treatments
- Renal and Vascular Pathologies
- Atrial Fibrillation Management and Outcomes
- Trauma and Emergency Care Studies
- Organ Transplantation Techniques and Outcomes
- Angiogenesis and VEGF in Cancer
- Vascular Malformations and Hemangiomas
- Heparin-Induced Thrombocytopenia and Thrombosis
Humacyte (United States)
2016-2023
Duke University
2014-2023
Duke Medical Center
2011-2021
Uniformed Services University of the Health Sciences
2019
University of Maryland, Baltimore
2006-2019
University of Maryland Medical System
2019
Triangle
2017-2019
Walter Reed National Military Medical Center
2019
Duke University Hospital
2003-2019
Yale University
2017-2018
Nonimmunogenic, tissue-engineered vascular grafts stored long-term maintain their patency, strength, and function after transplant in large-animal models.
Arterial tissue-engineering techniques that have been reported previously typically involve long waiting times of several months while cells from the recipient are cultured to create engineered vessel. In this study, we developed a different approach arterial tissue engineering can substantially reduce time for graft. Tissue-engineered vessels (TEVs) were grown banked porcine smooth muscle allogeneic intended recipient, using biomimetic perfusion system. The then decellularized, leaving...
Traditional vascular grafts constructed from synthetic polymers or cadaveric human animal tissues support the clinical need for readily available blood vessels, but often come with associated risks. Histopathological evaluation of these materials has shown adverse host cellular reactions and/or mechanical degradation due to insufficient inappropriate matrix remodeling. We developed an investigational bioengineered acellular vessel (HAV), which is currently being studied as a hemodialysis...
Long-term success in xenotransplantation is currently hampered by acute vascular rejection. The inciting cause of rejection not yet known; however, a variety observations suggest that the humoral immune response recipient against donor may be involved pathogenesis this process. Using pig-to-baboon heterotopic cardiac transplant model, we examined role antibodies development After transplantation into baboons, hearts from transgenic pigs expressing human decay-accelerating factor and CD59...
Species cross-reactivity facilitates the preclinical evaluation of potentially therapeutic molecules in animal models. Here we describe an vitro selection strategy which RNA ligands (aptamers) that bind both human and porcine thrombin were selected by "toggling" protein target between during alternating rounds selection. The "toggle" process yielded a family aptamers, all bound with high affinity. Toggle-25, characteristic member, inhibited two thrombin's most important functions: plasma...
To determine prospectively the immunologic response and adverse clinical events in surgical patients exposed to bovine thrombin during cardiac procedures.Topical is used extensively as a hemostatic agent cardiovascular surgery. Antibodies developing after exposure have been anecdotally associated with hemorrhagic complications.One hundred fifty-one undergoing procedures were recruited for this study before topical thrombin. Immunoassays antibody levels against both human coagulation proteins...
The chronic shortage in the supply of human organs available for allotransplantation has turned attention toward use animals as potential donors, with pigs most likely species under consideration. Hyperacute rejection, initial and immediate barrier to a pig-to-primate xenograft, been addressed by generation transgenic that express membrane-bound complement-regulatory proteins CD59 and/or CD55. Difficulty encountered third protein, CD46.We have generated using large genomic construct...
Background Restenosis remains a problem in hemodialysis access interventions. Paclitaxel-coated balloons have shown promise reducing access-related restenosis small trials. The primary hypotheses for our multicenter trial were superior effectiveness at 180 days and noninferior safety 30 of drug-coated balloon compared with conventional angioplasty treatment dysfunctional arteriovenous fistulas. Design, setting, participants, & measurements This randomized enrolled 285 patients fistulas...