A5101744586- Glioma Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- MicroRNA in disease regulation
- Anesthesia and Neurotoxicity Research
- Meningioma and schwannoma management
- Transplantation: Methods and Outcomes
- Anesthesia and Sedative Agents
- Organ Transplantation Techniques and Outcomes
- Organ and Tissue Transplantation Research
- Spinal Dysraphism and Malformations
- Neuroinflammation and Neurodegeneration Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Xenotransplantation and immune response
- Mechanical Circulatory Support Devices
- Bioinformatics and Genomic Networks
- Head and Neck Surgical Oncology
- CNS Lymphoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Cell Image Analysis Techniques
- Eosinophilic Esophagitis
- Renal Transplantation Outcomes and Treatments
- Treatment of Major Depression
- Advanced Neuroimaging Techniques and Applications
- Pituitary Gland Disorders and Treatments
Capital Medical University
2004-2025
Beijing Tian Tan Hospital
2020-2025
Chinese Institute for Brain Research
2020-2025
Capital University
2023
Beijing Institute of Neurosurgery
2022
National Clinical Research
2016-2022
National Clinical Research Center for Digestive Diseases
2020
Duke Medical Center
1998-2013
Duke University Hospital
1998-2011
University of California, Davis
2000
Long-term success in xenotransplantation is currently hampered by acute vascular rejection. The inciting cause of rejection not yet known; however, a variety observations suggest that the humoral immune response recipient against donor may be involved pathogenesis this process. Using pig-to-baboon heterotopic cardiac transplant model, we examined role antibodies development After transplantation into baboons, hearts from transgenic pigs expressing human decay-accelerating factor and CD59...
We examined the relationship between intrapulmonary particle distribution of carbonaceous and mineral dusts remodeling airways along anatomically distinct airway paths in lungs Hispanic males from central valley California. Lung autopsy specimens Fresno County Coroner's Office were prepared by intratracheal instillation 2% glutaraldehyde at 30 cm H(2)O pressure. Two into apico-posterior apico-anterior portions left upper lung lobe followed. Tissue samples for histologic analysis generally...
Abstract Background Astrocytoma is a common aggressive intracranial tumor and presents formidable challenge in the clinic. Association of altered DNA methylation patterns promoter CpG islands with expression profile cancer-related genes, has been found many human tumors. Therefore, status as such may serve an epigenetic biomarker for both diagnosis prognosis tumors, including astrocytoma. Methods We used specific PCR conjunction sequencing verification to establish island thirty four genes...
OBJECTIVE The aim of this study was to evaluate the cortical nonenhancing tumor infiltration (CONTIN) sign as a predictive imaging biomarker for IDH-mutant gliomas, including diffuse gliomas with and without contrast enhancement. METHODS Imaging data were collected from patients (grades 2–4) at Beijing Tiantan Hospital (BTH) January 2019 December 2021 (training set, n = 526) University California, San Francisco, preoperative glioma MRI dataset (UCSF PDGM; validation 501). Two independent...
<title>Abstract</title> Primary central nervous system lymphoma (PCNSL) is a rare and aggressive diffuse large B-cell (DLBCL) subtype restricted to the CNS, with variable response high-dose methotrexate frequent relapse. We conducted first comprehensive proteomic analysis of 52 PCNSL tumors investigate mechanisms chemoresistance, relapse, therapeutic stratification. Chemoresistant showed increased ribosomal biogenesis reduced oxidative phosphorylation. Relapsed exhibited PI3K/AKT activation...
Objective To characterize co-deletion of chromosome 1p/19q and IDH1/2 mutation in Chinese brain tumor patients to assess their associations with clinical features. Methods In a series 528 gliomas, pathological radiological materials were reviewed. Pathological constituents subsets, incidences gliomas by regions sides the analyzed. Results Overall, 1p 19q was detected 339 FISH method while sequence determined 280 patients. Gliomas frontal, temporal insular origin had significantly different...
The brain compensation mechanism in postoperative delirium (POD) has not been reported. We uncovered the by exploring association between POD and glioma grades, relationship preoperative structural functional with patients frontal glioma.A total of 335 adult were included. multivariable analysis examined tumor grade POD. Then, 20 left lobe who had presurgical MRI data Montreal Cognitive Assessment (MoCA) this cohort analyzed. measured gray matter volume (GMV) connectivity (FC) (n = 8)...
OBJECTIVE Patients with frontal gliomas often experience executive dysfunction (EF-D) before surgery, and the changes in brain plasticity underlying this effect remain obscure. In study, authors aimed to assess whole-brain structural functional alterations by using MRI resting-state (rs-fMRI) glioma patients or without EF-D. METHODS Fifty-seven were admitted prospectively authors’ institution assigned one of two groups: 1) normal function (EF-N) group 2) EF-D group, based on patient results...
The rarity of primary central nervous system lymphoma (PCNSL) and treatment heterogeneity contributes to a lack prognostic models for evaluating posttreatment remission. This study aimed develop validate radiomic-based predict the durable response (DR) high-dose methotrexate (HD-MTX)-based chemotherapy in PCNSL patients.
Abstract Purpose Peritumoral edema (PTE) in intracranial meningiomas correlates to surgical outcomes. But only depending on preoperative PTE meningioma does not accurately predict the prognosis after resection. We aimed investigate whether postoperative could improve prediction of patients with PTE. Methods retrospectively reviewed MRI scans 3 months operation 371 that underwent surgery between 2015 and 2017. All were classified into two different groups according had fadeaway within...
Objective To investigate the frequencies of combining loss ofheterozygosity (LOH) chromosome 1p/19q in gliomas different pathologies and analyze clinical factors correlated withcombining LOH by logistic regression.Methods Tumor samples from 127 giioma patients were collected.The status 1p 19q was evaluated fluorescence situ hybridization (FISH) analyzed.Results The agtrocytic,oligoagtrocytic oligodendrnglial tumors 19.30%,50.00% 80.77%respectively.The oligoagtrocytic oligodendroglial hisher...
Objective To analyze the incidence and risk factors of postoperative delirium (POD) in patients with glioma to explore association between WHO (World Health Organization) tumor grades POD. Methods A second analysis clinical data from 113 adult a single-center, prospective cohort study 800 neurosurgery was conducted March 2017 February 2018 at Department Critical Medicine (ICU), Beijing Tiantan Hospital, Capital Medical University. Patients were assessed for on first third days post...
Background: Depressive symptoms occurs more than 40% in neurosurgery. However, no effective measures proved to resolve depression within the increasingly decreased hospital stay. Methods: PASSION was a single-center, randomized, placebo-controlled and double-blinded trial recruited patients from 2017 2018 Beijing Tiantan Hospital, Capital Medical University. Eligible were 18 65 years old having elective surgical resection of brain tumor with moderate-to-severe depression. Participants...