A5103199412- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Management of metastatic bone disease
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Oral and Maxillofacial Pathology
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- Reconstructive Surgery and Microvascular Techniques
- Vascular Tumors and Angiosarcomas
- Knee injuries and reconstruction techniques
- Pancreatic and Hepatic Oncology Research
- Diverticular Disease and Complications
- Shoulder and Clavicle Injuries
- Spinal Fractures and Fixation Techniques
- Pediatric Hepatobiliary Diseases and Treatments
- Surgical site infection prevention
- Respiratory viral infections research
- Glioma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Pelvic floor disorders treatments
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Gallbladder and Bile Duct Disorders
Peking University
2025
People's Liberation Army 401 Hospital
2021-2024
First Affiliated Hospital of Bengbu Medical College
2023-2024
Academy of Military Medical Sciences
2023-2024
Heilongjiang Academy of Sciences
2024
Huashan Hospital
2022-2024
Fudan University
2022-2024
Zhongnan Hospital of Wuhan University
2018-2023
Wuhan University
2018-2023
Weifang Medical University
2023
Osteosarcoma is the most common primary malignant bone tumor, occurring mainly in children and adolescents, limbs are main affected sites. At present, limb‐salvage treatment considered as an effective basic standard for osteosarcoma of limb. China has a vast territory, but development technology not balanced,which requires sufficient theoretical coverage, strong technical guidance application guidelines to osteosarcoma. Therefore, standardize promote surgery improve success rate treatment,...
Postoperative nausea and vomiting (PONV) are frequent harmful complications after neurosurgery. Current pharmacy-based treatment is the standard of care; it, however, lacks efficiency. Invasive noninvasive acupuncture at P6 meridian point has been shown to be effective in prevention PONV. We evaluated effectiveness transcutaneous electrical acupoint stimulation (TEAS) for prophylaxis PONV patients undergoing infratentorial craniotomy.In this prospective, blind, randomized study, received...
There is controversy regarding the impact of infection on long-term prognosis in osteosarcoma patients. Clinical trials and experiments relating to this field could bring reconsideration immunotherapy for osteosarcoma. The clinical records were reviewed 125 patients with a mean follow-up 5.1±3.9 years (range, 0.5-19.8 years), review literature was also carried out. Chronic localized infections (but not systemic infection) determined 6 (4.8%). Similar chemotherapeutic regimens (P=1.00)...
Abstract Utilizing innovative methods to advance the research and development (R&D) of health products enhance their accessibility has become crucial achieving universal coverage, addressing public emergencies, promoting population wellbeing. However, structural contradictions do exist in supply demand Association Southeast Asian Nations (ASEAN). With joint support Ministry Science Technology China, Education, China-ASEAN Center, Peking University established Cooperation Center for...
Giant cell tumor (GCT) of the bone is a relatively common primary tumor. Treatment with simple curettage often results in high local recurrence rate. Tumor resection and reconstruction prosthesis or an allograft has low rate recurrence; however, patient's native joint function becomes significantly impaired. With development usage aggressive curettage, it priority to treat GCT method that reduces preserves joint. To evaluate feasibility treating cement filling using internal fixation oral...
Microwave ablation has been used to treat bone tumors in extremities for more than 30 years. With improved recognition, updated microwave equipment, and expanded clinical application, recently widely tumors. To standardize the application of treatment limbs, research results experience involving use limbs have summarized, a guideline designed. This is aimed at providing reliable basis indications, preoperative evaluation decision‐making, perioperative treatment, complications, other issues...
Gallbladder cancer (GBC) is among the most lethal malignancies in world, with a prognosis that extremely poor. The results of previous studies suggest tripartite motif containing 37 (TRIM37) contributes to progression numerous types cancer. Nevertheless, there little knowledge about molecular mechanisms and functions TRIM37 GBC.A clinical significance assessment was conducted on following its detection by immunohistochemistry. In vitro vivo functional assays were performed investigate role...
(1) Objective: High-dose methotrexate (hdmtx) is a common therapeutic agent in the treatment of osteosarcoma. However, hdmtx highly toxic and requires complex pharmacokinetic monitoring leucovorin rescue. Thus, alternative strategies are necessary. Here, we analyzed clinical efficacy dia regimen (cisplatin–ifosfamide–doxorubicin) to evaluate its potential as an hdmtx–based therapy. (2) Methods: Patients received 12 cycles chemotherapy administered over 2 years (2 preoperative 10...
Objective: To study the long‐term outcomes and complications of giant cell tumors around knee treated with en bloc resection reconstruction prosthesis. Methods: From January 1991 to March 2005, 19 patients (11 men, 8 women, average age 35.4 years) were in our hospital domestic prosthesis (15 hinge 4 rotating‐hinge knee). The distal femur was involved 12 proximal tibia 7 cases. Nine primary 10 recurrent. All cases Campanacci grade III. affected limb functions evaluated by Musculoskeletal...
We tried to compare the functional and psychosocial outcomes after various reconstruction methods according tumor location following resection of osteosarcoma in distal femur.We retrospectively reviewed 51 patients who underwent limb-salvage surgery femur our institution, 30 males 21 females with an average age years (range 13-51 years). classified into 3 types, organized affected limb wide resection. MSTS QOL scores were used analyze psychological outcomes.After a mean follow-up 43 months...
The optimal reconstructive method after diaphyseal malignant bone tumor resection remains controversial. This multicenter clinical study was designed to investigate the value and complications of segmental prosthesis in repair defects. We present 49 patients from three centers treated with wide for primary or metastatic tumors involving diaphysis femur, tibia, humerus, ulna, followed by reconstruction using a modular intramedullary prosthesis. Enrolled included 23 men 26 women mean age 63.3...
Abstract Unplanned therapy for extremity osteosarcoma can result in erroneous surgical procedures and lack of neoadjuvant chemotherapy before the first operation. Our aim was to compare prognosis between patients with who received unplanned those standard treatment. This a retrospective review appropriate treatment (n = 79) 24) June 2000 October 2014. Survival rate, local recurrence rate metastasis were compared two groups. We found that had higher (41.7% vs. 21.5%; P 0.049) shorter mean...
To study the long-term outcomes of inactivated bone reimplantation with preservation epiphysis in children distal femoral osteosarcomas.Over 10 years, five (mean age 9.2 one boy and four girls) osteosarcomas underwent following chemotherapy our hospital. Three patients were type I on MRI classification (one pathological fracture), two II. The therapeutic regime was cycles preoperative chemotherapy, surgery six postoperative chemotherapy.Five followed up for 60-126 months 82 months). No local...
Objective To study the impacts of tumor location, nature and extent bone destruction on selection operative protocol for extremity osteosarcoma ( OS ). Methods The medical records 201 patients with treated in our institute from D ecember 1999 to J une 2014 were retrospectively reviewed. Ninety eligible (56 males 34 females) average age 20 ± 11 years (range, 4–40 years) enrolled. Tumor locations categorized as diaphyseal (4; diaphysis group) or juxta‐articular (86); latter being subclassified...
This study was designed to evaluate the efficacy and safety of apatinib in patients with advanced osteosarcoma pulmonary metastases following failed first-line chemotherapy. There were 10 metastases, whose chemotherapy had failed, received treatment as a single agent. All at least 1 measurable lung tumor. Progression free survival (PFS), overall (OS), objective response rate (ORR), disease control (DCR), treatment-related adverse effects (AEs) reviewed evaluated. Tumor assessed by evaluation...
Objectives To demonstrate the functional results and emotional acceptance after scapulectomy for various malignant shoulder tumors. Methods Eight patients with tumors who had undergone between A pril 2004 M arch 2014 were retrospectively reviewed. They comprised seven men one woman their mean age was 54 years (range, 24–69 years). All diagnosed by pathological examination of biopsy specimens. The metastatic in four cases, having originated from a primary carcinoma liver patient, lung patient...
<b><i>Summary</i></b><b><i>Aim: </i></b>To evaluate clinical outcomes in patients who underwent alcohol-inactivated autograft replantation with joint preservation for the treatment of osteosarcoma distal femur. <b><i>Patients and Methods: </i></b>10 (7 men, 3 women; mean age: 20.1 years) were treated. 9 had Enneking stage IIb tumors 1 patient III. The follow-up time was 34 months. All obtained first-stage healing....
Objectives To evaluate treatments and prognostic factors for the myxoid liposarcoma in extremities. Methods We retrospectively reviewed 34 patients histologically diagnosed with arising extremities, treated our hospital from 2010 to 2017. recorded tumor locations, max diameter, operations, complications, radiation, chemotherapy, survival, recrudescence, metastases. Overall treatments, were subsequently analyzed. Results The mean age of extremities was 49.1 years, follow‐up period 65.1...