A5088873947- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Cardiac tumors and thrombi
- Oral and Maxillofacial Pathology
- Orthopaedic implants and arthroplasty
- Management of metastatic bone disease
- Vascular Tumors and Angiosarcomas
- Pelvic and Acetabular Injuries
- Musculoskeletal synovial abnormalities and treatments
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Total Knee Arthroplasty Outcomes
- Reconstructive Surgery and Microvascular Techniques
- CAR-T cell therapy research
- Cancer Diagnosis and Treatment
- Aortic aneurysm repair treatments
- Orthopedic Surgery and Rehabilitation
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Bone Tissue Engineering Materials
- Shoulder Injury and Treatment
- RNA Research and Splicing
- Medical Imaging and Pathology Studies
- Nanoplatforms for cancer theranostics
- Shoulder and Clavicle Injuries
West China Hospital of Sichuan University
2015-2024
Sichuan University
2015-2024
Christie's
2017
Creative Commons
2017
Weatherford College
2014
The aim of research is to fabricate nanostructured hydroxyapatite (HA) coatings on the titanium via electrochemical deposition (ED). Additionally, biological properties ED-produced HA (EDHA) with a plate-like nanostructure were evaluated in vitro and vivo by undertaking comparisons those prepared acid/alkali (AA) treatment plasma spray-produced (PSHA) nanotopography-free coatings.Nanoplate-like through ED, PSHA fabricated. surface morphology, phase composition, roughness, wettability these...
Objective To investigate the values of clinical application lower abdominal aorta balloon occluding in pelvic and sacral tumor resection. Method From January 2004 to 2010, 137 patients were diagnosed as or tumors underwent surgery our institution. Forty-five resection combined with control hemorrhage (balloon group), remaining 92 conventional (conventional therapy group). We compared operative time, intraoperative hemorrhage, amount blood transfusion, postoperative complications, mean...
Background: Treatment for melanoma is a challenging clinical problem, and some new strategies are worth exploring. Purpose: The objective of this study was to investigate the in vitro vivo anti-melanoma effects hydroxyapatite nanoparticles (HANPs) discuss involved material factors. Materials methods: Five types HANPs, ie, HA-A, HA-B, HA-C, HA-D, HA-E, were prepared by wet chemical method combining with polymer template appropriate post-treatments. as-prepared five HANPs on inhibiting...
Currently, it is challenging to treat giant cell tumor (GCT) of distal radius. For Campanacci grade III or recurrent GCTs, en bloc resection has been accepted as a better treatment option. Although numerous methods are available for reconstruction, all them have some limitations in joint function and complications. In this study, our aims were the GCT radius with uncemented three-dimensional (3D)-printed prosthesis present evaluate surgical techniques short-term outcomes.Between September...
Abstract Background En bloc excision has been increasingly used for the management of giant cell tumors (GCTs) in distal radius. An osteoarticular allograft extensively decades, and custom-made prosthesis reconstruction more recently applied. We aimed to compare clinical outcomes two procedures. Methods retrospectively analyzed 30 patients with Campanacci III or recurrent GCTs radius follow-up at a mean 33.2 months. In total, 15 underwent (allograft group) received cementless...
Microwave ablation has been used to treat bone tumors in extremities for more than 30 years. With improved recognition, updated microwave equipment, and expanded clinical application, recently widely tumors. To standardize the application of treatment limbs, research results experience involving use limbs have summarized, a guideline designed. This is aimed at providing reliable basis indications, preoperative evaluation decision‐making, perioperative treatment, complications, other issues...
In recent years, using hydroxyapatite nanoparticles (HANPs) for tumor therapy attracted increasing attention because HANPs were found to selectively suppress the growth of cells but exhibit ignorable toxicity normal cells.This study aimed investigate capacities with different morphologies and particle sizes against two kinds osteosarcoma (OS) cells, human OS 143B rat UMR106 cells.Six prepared by wet chemical method. Then, antitumor effect these was characterized means in vitro cell...
Radical sacral surgery can be associated with life-threatening blood loss. Effective and safe methods for controlling this loss remain elusive. We here report the use of an inflatable sizing balloon to intermittently occlude distal abdominal aorta control during tumor resections. The catheter was introduced into via femoral artery. Pulse oxygen saturation signals from bilateral toes ultrasonography were used guide confirm location in renal arteries. deflated 10 min after each 60 occlusion...
// Yong Zhou 1,* , Fan Tang 1,2,* Yiying Wang 3 Li Min 1,2 Yi Luo 1 Wenli Zhang Rui Shi Hong Duan and Chongqi Tu Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 2 Sarcoma Biology Laboratory, Center for Connective Tissue Oncology, Massachusetts General Boston, MA, USA Pathology, * These authors have contributed equally to this study Correspondence to: Tu, email: Keywords : alveolar soft part sarcoma, vascular endothelial growth factor receptor-2,...
The prognostic significance of Hypoxia-inducible factor-1α (HIF-1α) in patients with bone and soft tissue sarcoma remains controversial. To investigate the impact its expression on survival outcomes, we performed a meta-analysis. Comprehensive literature searches were conducted PubMed, Web Science, Embase Cochrane Library. A total 16 studies published from 2006 to 2015 included. We found that HIF-1α was significantly associated higher rate metastasis (RR 3.21, 95 % CI 2.12-4.84, P < 0.001),...
Anlotinib, a novel multitarget kinase inhibitor of VEGFR, FGFR, PDGFR and c-Kit, has proven to be effective safe for refractory soft tissue sarcoma patients, but not been examined in recurrent or metastatic primary malignant bone tumors clinical trial setting.This is multicenter single-arm trial. Patients with pathologically were eligible. Anlotinib was administered orally at 12 mg per day. Each cycle consisted 2 weeks treatment followed by 1-week off-treatment. The endpoint progression-free...
Bone metastasis is common in lung cancer patients and associated with reduced quality of life overall median survival, so the early detection bone monitoring its status very important for clinicians. Serum bone-specific alkaline phosphatase (BAP), osteocalcin (OC), beta isomer C-terminal telopeptide type I collagen (beta-CTX) cross-linked (ICTP) were compared regard to their usefulness as indicators cancer. The serum concentrations 4 markers measured by commercially available tests 96 male...
Rationale: Osteosarcoma is the most common malignant bone tumor in children and adolescents. Pulmonary metastases lead to a significantly increased risk of death. Apatinib, new potent oral small-molecule tyrosine kinase inhibitor targeting intracellular domain vascular endothelial growth factor receptor 2 (VEGFR-2), shows survival benefits treating advanced or metastatic gastric adenocarcinoma, non-squamous non-small cell lung cancer breast cancer. However, its efficacy osteosarcoma has not...
Antidifferentiation noncoding RNA (ANCR), a newly identified long (lncRNA), plays critical role for stem cells to maintain undifferentiated cell state. However, the functions of ANCR in human cancers have not been reported. This study is designed explore osteosarcoma.Lentivirus-mediated (shRNA) was applied silence osteosarcoma lines U2OS and Saos-2. Cell viability measured by MTT assay. Colony-forming ability colony formation cycle progression determined flow cytometry with propidium iodide...
The routine iliofemoral approach and its modifications in type II+III resection require extensive skin incision massive periacetabular muscle detachment, leading to prolonged hospital stay, increased complication incidence, impaired lower limb function. Under the management of an enhanced recovery after surgery (ERAS) protocol, a combined modified Gibson ilioinguinal (MGMII) was used avoid unnecessary soft tissue trauma during tumor therefore advantageous patients' return normal...
Purpose The relationship between indeterminate pulmonary nodules (IPNs) and metastasis is difficult to determine. We expect explore a predictive model that can assist in indicating the nature of IPNs, as well predicting probability metachronous osteosarcoma patients. Patients methods conducted retrospective study including 184 patients at West China Hospital from January 2016 2021. Hematological markers clinical features were collected analyzed. Results In this study, we constructed an...
Abstract Background Customized 3D-printed pelvic implants with a porous structure have revolutionized periacetabular defect reconstruction after tumor resection, offering improved osteointegration, long-term stability, and anatomical fit. However, the lack of an established classification system hampers implementation progress. Methods We formulated novel based on morphology hemipelvis endoprostheses. It integrates surgical approach, osteotomy guide plate prosthesis design, postoperative...
Abstract Purpose Resection of pelvic bone tumours and subsequent girdle reconstruction pose formidable challenges due to the intricate anatomy, weight-bearing demands, significant defects. 3D-printed implants have improved by enabling precise resections with customized guides, offering tailored solutions for diverse defect morphology, integrating porous surface structures promote osseointegration. Our study aims evaluate long-term efficacy feasibility hemipelvic following resection malignant...