A5102814027- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Catalytic Alkyne Reactions
- Catalytic Cross-Coupling Reactions
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- Synthesis and Catalytic Reactions
- Analytical Chemistry and Chromatography
- Fluorine in Organic Chemistry
- High voltage insulation and dielectric phenomena
- Nanoplatforms for cancer theranostics
- Silicone and Siloxane Chemistry
- Muon and positron interactions and applications
- Natural product bioactivities and synthesis
- Covalent Organic Framework Applications
- Chemical Synthesis and Reactions
- Bone Tissue Engineering Materials
- Carbon dioxide utilization in catalysis
- Lightning and Electromagnetic Phenomena
- Organoboron and organosilicon chemistry
- 3D Printing in Biomedical Research
- CO2 Reduction Techniques and Catalysts
- Aerosol Filtration and Electrostatic Precipitation
- Photonic and Optical Devices
Sichuan Cancer Hospital
2025
University of Electronic Science and Technology of China
2025
Chengdu University of Traditional Chinese Medicine
2025
Wuhan University
2012-2024
Sichuan University
2001-2024
West China Hospital of Sichuan University
2016-2024
Shenzhen Second People's Hospital
2023
Chengdu University
2019-2021
Sichuan Normal University
2021
State Council of the People's Republic of China
2020
An oxidant-free dehydrogenative sulfonylation of α-methyl-styrene derivatives was developed for the construction allylic sulfones by using eosin Y as a photosensitizer in conjunction with cobaloxime catalyst. The process features low-cost metal catalyst and atom economy, which provides an appealing strategy future synthetic chemistry.
Abstract Direct radical additions to terminal alkynes have been widely employed in organic synthesis, providing credible access the anti‐Markovnikov products. Because of Kharasch effect, regioselective control for formation Markovnikov products still remains a great challenge. Herein, we develop transition‐metal‐free, visible light‐mediated addition S‐nucleophiles alkynes, furnishing wide array α‐substituted vinyl sulfones with exclusive regioselectivity. Mechanistic investigations...
Bone tumors, particularly osteosarcoma, are prevalent among children and adolescents. This ailment has emerged as the second most frequent cause of cancer-related mortality in Conventional treatment methods comprise extensive surgical resection, radiotherapy, chemotherapy. Consequently, management bone tumors regeneration poses significant clinical challenges. Photothermal tumor therapy attracted considerable attention owing to its minimal invasiveness high selectivity. However, key...
We have disclosed for the first time copper-promoted C≡N triple bond cleavage of coordinated cyanide anion under a dioxygen atmosphere, which enables nitrogen transfer to various aldehydes. Mechanistic study this unprecedented transformation suggests that single electron-transfer process could be involved in overall course. This protocol provides new pattern ion and would eventually lead more useful synthetic pathway nitriles from
A visible light mediated radical C–H phosphorization of benzothiazoles with O<sub>2</sub> as the sole oxidant toward synthesis arylphosphonates was developed.
An iridium-catalyzed B–H bond insertion reaction between borane adducts and sulfoxonium ylides to afford α-boryl carbonyls has been developed. The starting materials are safe readily available. In addition, analogues of ylides, such as sulfonium salts could also be amenable the reaction.
Iridium-complex-incorporated porous organic polymers have been prepared to realize the photocatalysis of four transformations with previously unattainable recyclability.
Intermittent delivery of parathyroid hormone (PTH) could effectively promote bone regeneration, but the need for daily injection administration has limited its further clinical applications. Exposure to magnetic stimulation regulate cell fate osteogenesis. Herein, we developed a magnetized hydrogel with programmed PTH release and simultaneous actuation osteogenic commitment. Ag dual-cross-linked was formulated as GelMA-PVA (GP) biphasic reservoir nanoparticles (GPM) (GPMP). Macroscopic...
A highly selective radical dioxygenation of alkenes using hydroxamic acid and O2 was developed, copper/cobalt used as the catalyst without assistance any additional ligands or bases. Mechanistic investigation disclosed that copper salt work in concert to activate acid, with Cu(I) Cu(II) concurrently existing this reaction.
The first example of DMSO serving not only as a solvent but also an oxidant to promote the oxidation Cu(I) Cu(II) has been demonstrated. X-ray absorption and electron paramagnetic resonance evidence revealed single-electron redox process where could oxidize Cu(II). novel discovery guided rational design copper-catalyzed oxidative cyclization aryl ketones with styrenes furans, providing new method for synthesis multiaryl-substituted furans from cheap readily available starting materials.
Graphene oxide, a green and recyclable catalyst, was developed to synthesize 3-sulfenylindoles in water.
Oral squamous cell carcinoma (OSCC) represents a heterogeneous group of malignancies originating from the mucosal lining oral cavity. Current treatment modalities primarily involve surgery, chemotherapy, and radiotherapy. Despite use multimodal therapy, 5 year overall survival rate for OSCC remains around 50%, underscoring need development nontoxic agents with potent antitumor activity. Extracellular vesicles (EVs) are nanoscale, membrane-bound structures that can selectively deliver small...
Spontaneous O<sub>2</sub> fixation by just mixing activated alkenes and thiols at room temperature is rationally demonstrated.
An effective strategy to synthesize spirocyclic compounds, [imidazole-4,1'-indene], has been efficaciously developed relied on Rh(III)-catalyzed [3 + 2] spirocyclization of 2H-imidazoles and 1,3-diynes with excellent chemselectivity regioselectivity. This protocol shows a straightforward way construct the versatile compounds wide functional group compatibility, high atom economy, diverse functionalization products.
Two metal porous organic polymers (POPs) that contain the [Ru(bpy)3]2+ cores are prepared via one-pot Suzuki-Miyaura coupling reactions. Both Ru-POPs thermally stable at up to 340 °C in air and do not dissolve all solvents tested. One of POPs has been revealed be highly effective reusable as a heterogeneous photocatalyst for visible light-driven enantioselective alkylation aldehydes. After 10 cycles, catalyst still maintains enantioselectivity, while activity just decreases slightly.
An efficacious synthetic solution to offer functionalized bisindoles and indoles has been developed based on catalyst-controlled C–H functionalization of pyrazolidinones 1,3-diynes with highly selective control both chemoselectivity regioselectivity. This straightforward pathway conquers chemo- regioselectivity challenges concerning the use 1,3-diynes.
A divergent synthetic strategy to functionalize the indole nucleus with readily available 2-furylcarbinols was developed. It found that 3-(4-oxo-2-cyclopentenyl)indoles were obtained in moderate good yields (up 89%) through Piancatelli reaction catalyzed by ZnCl2, whereas employment of Brønsted acid TFA afforded directly coupled product 3-(2-furyl)indoles 87%) via deprotonation-rearomatization route.
To achieve a best promotion effect of photocatalytic activity, an optimized interface between graphene and TiO2 is highly desirable, which is, however, difficult to realize via conventional preparation the graphene/oxide composites. this end, we here develop novel strategy directly grow on anatase-TiO2 (a-TiO2) nanosheet ambient pressure chemical vapor deposition (AP-CVD) method using acetylene as precursor. Such recipe successfully avoids intercalating contaminations, meantime ensures...
The iridium‐catalyzed aromatic C–H alkylation followed by intramolecular annulation reactions between N ‐aryl‐2‐aminopyridines and sulfoxonium ylides for the synthesis of 2‐alkyl indoles is described. This highly efficient step‐economical cyclization reaction displays excellent functional group compatibility regioselectivity. Afterwards, directing in can be readily removed to obtain free N–H indoles. Thus, ylide, a carbene precursor, proved as useful surrogate diazo compounds activation chemistry.
An interesting and tunable hydrosulfonylation of 3-cyclopropylideneprop-2-en-1-ones with sodium sulfinates acetic acid is described. The corresponding β- or γ-addition products can be produced in good to excellent yields high selectivities, respectively. A rationale for these transformations proposed base on the controlled experiments.
The ionic liquid [BMIM][NTf2] was developed as an ideal medium in which Rh(III)-catalyzed directed C–H carbenoid coupling reactions can be conducted efficiently and sustainably. More significantly, the not only achieve recycle of catalyst system but also improve efficiency catalyst, presenting that accomplished at room temperature within a short period time. Thus, this work would useful expanding applications activation strategies tools for assembling novel organic molecules.