A5035860088- Tactile and Sensory Interactions
- Interactive and Immersive Displays
- Cancer Genomics and Diagnostics
- Virtual Reality Applications and Impacts
- Advanced Sensor and Energy Harvesting Materials
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Obstructive Sleep Apnea Research
- Augmented Reality Applications
- CRISPR and Genetic Engineering
- Neuroscience of respiration and sleep
- Prostate Cancer Treatment and Research
- Innovative Human-Technology Interaction
- Hippo pathway signaling and YAP/TAZ
- Hand Gesture Recognition Systems
- Pharmaceutical studies and practices
- Perovskite Materials and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Autism Spectrum Disorder Research
- Usability and User Interface Design
- MicroRNA in disease regulation
- Gaze Tracking and Assistive Technology
- Cancer-related molecular mechanisms research
- Tracheal and airway disorders
- Teleoperation and Haptic Systems
China-Japan Friendship Hospital
2017-2025
National Clinical Research Center for Digestive Diseases
2017-2025
Institute of Software
2020-2025
Chinese Academy of Sciences
2020-2025
Fudan University
2025
Sichuan Cancer Hospital
2025
University of Electronic Science and Technology of China
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
University of Chinese Academy of Sciences
2020-2024
Kettering University
2022-2024
In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR) dependence leads to clinically aggressive tumors with few therapeutic options. We used ATAC-seq (assay for transposase-accessible chromatin sequencing), RNA-seq, and DNA sequencing investigate 22 organoids, six patient-derived xenografts, 12 cell lines. identified well-characterized AR-dependent neuroendocrine subtypes, as well two AR-negative/low groups: a Wnt-dependent subtype, stem cell-like (SCL) subtype...
In a flexible perovskite solar cell, the bottom interface between and electron-transporting layer is critical in determining its efficiency reliability. High defect concentrations crystalline film fracturing at substantially reduce operational stability. this work, liquid crystal elastomer interlayer intercalated into device with charge transfer channel toughened by aligned mesogenic assembly. The molecular ordering instantly locked upon photopolymerization of diacrylate monomers...
Abstract Skin-integrated haptic interfaces that can relay a wealth of information from the machine to human are great interest. However, existing devices not yet able produce cues compatible with skin. In this work, we present stretchable soft actuators for feedback, which match perception range, spatial resolution, and stretchability Pressure-amplification structures fabricated using scalable self-assembly process ensure an output pressure beyond skin threshold. Due minimized device size,...
Abstract More than 70% of human information comes from vision. The eye is one the most attractive sensing sites to collect biological parameters. However, it urgent develop a cost‐effective and easy‐to‐use approach monitor eyeball in minimally invasive way instead current smart contact lenses or camera‐based eyeglasses. Here, biomimetic mineralization strategy developed prepare large‐grained perovskite film on glass with prepared ITO electrodes, which displays on–off ratio close 300 times at...
Abstract Defining the genetic drivers of cancer progression is a key in understanding disease biology and developing effective targeted therapies. Chromosome rearrangements are common feature human malignancies, but whether they represent bona fide therapeutically actionable targets, requires functional testing. Here, we describe generation transgenic, inducible CRISPR-based mouse systems to engineer study recurrent colon cancer-associated EIF3E–RSPO2 PTPRK–RSPO3 chromosome vivo . We show...
Abstract KRAS is the most frequently mutated oncogene in cancer, yet there little understanding of how specific amino acid changes affect tumor initiation, progression, or therapy response. Using high-fidelity CRISPR-based engineering, we created an allelic series new LSL-Kras mutant mice, reflecting codon 12 and 13 mutations that are highly prevalent lung (KRASG12C), pancreas (KRASG12R), colon (KRASG13D) cancers. Induction each allele either murine revealed striking quantitative qualitative...
Abstract Dysfunctional immune responses contribute critically to the progression of Coronavirus Disease-2019 (COVID-19), with macrophages as one main cell types involved. It is urgent understand interactions among permissive cells, macrophages, and SARS-CoV-2 virus, thereby offering important insights into effective therapeutic strategies. Here, we establish a lung macrophage co-culture system derived from human pluripotent stem cells (hPSCs), modeling host-pathogen interaction in infection....
Oral squamous cell carcinoma (OSCC) represents a heterogeneous group of malignancies originating from the mucosal lining oral cavity. Current treatment modalities primarily involve surgery, chemotherapy, and radiotherapy. Despite use multimodal therapy, 5 year overall survival rate for OSCC remains around 50%, underscoring need development nontoxic agents with potent antitumor activity. Extracellular vesicles (EVs) are nanoscale, membrane-bound structures that can selectively deliver small...
Foot-based gestures have recently received attention as an alternative interaction mechanism in situations where the hands are pre-occupied or unavailable. This paper investigates suitable real-world mappings of foot to invoke commands and interact with virtual workspaces. Our first study identified user preferences for mapping common mobile-device gestures. We distinguish these terms discrete continuous command input. While foot-based input has relatively few parameters control, requires...
Current haptic devices are often bulky and rigid, making them unsuitable for ubiquitous interaction scenarios where the user must also interact with real world. To address this gap, we propose HydroRing, an unobtrusive, finger-worn device that can provide tactile sensations of pressure, vibration, temperature on fingertip, enabling mixed-reality interactions. Different from previous explorations, HydroRing in active mode delivers using liquid travelling through a thin, flexible latex tube...
The WNT pathway is a fundamental regulator of intestinal homeostasis, and hyperactivation signaling the major oncogenic driver in colorectal cancer. To date, there are no described mechanisms that bypass dependence tumors. Here, we show although suppression blocks tumor growth most organoid vivo cancer models, accumulation cancer-associated genetic alterations enables drug resistance WNT-independent growth. In epithelial cells harboring mutations KRAS or BRAF, together with disruption TP53...
Current wearable interfaces are designed to support short-duration tasks known as micro-interactions. To productive for everyday analytic tasks, designers can leverage natural input methods such direct manipulation and pointing. Such now available in virtual, mobile environments thanks miniature depth cameras mounted on head-worn displays (HWDs). However, these techniques have drawbacks, fatigue limited precision. overcome limitations, we explore combined input: hand tracking data from a...
Abstract To study genetic factors influencing the progression and therapeutic responses of advanced prostate cancer, we developed a fast flexible system that introduces alterations relevant to human disease directly into glands mice using tissue electroporation. These electroporation-based genetically engineered mouse models (EPO-GEMM) recapitulate features traditional germline and, by modeling linked late-stage disease, can produce tumors are metastatic castration-resistant. A subset with...
Abstract Colorectal cancer is driven by mutations that activate canonical WNT/β-catenin signaling, but inhibiting WNT has significant on-target toxicity, and there are no approved therapies targeting dominant oncogenic drivers. We recently found activating a β-catenin–independent branch of signaling inhibits GSK3-dependent protein degradation induces asparaginase sensitivity in drug-resistant leukemias. To test predictions from our model, we turned to colorectal because these cancers can...
Multi-user locomotion in VR has grown increasingly common, posing numerous challenges. A key factor contributing to these challenges is the gaps experience between active and passive users during co-locomotion. Yet, there remains a limited understanding of how what extent experiential manifest diverse multi-user co-locomotion scenarios. This paper systematically explores physiological psychological indicators across various situations. Such situations include when walk, fly by joystick, or...
In this paper we describe the use of kick gestures for interaction with mobile devices. Kicking is a well-st udied leg action that can be harnessed in contexts where hands are busy or too dirty to interact phone. examine design space kicki ng as an technique through two user studies. The first study investigated how well users were able control direction their kicks. Users aim kicks best when movement range divided into segments at least 24°. second looked velocity kick. We found varying...
We present LensGesture, a pure software approach for augmenting mobile interactions with back-of-device finger gestures. LensGesture detects full and partial occlusion as well the dynamic swiping of fingers on camera lens by analyzing image sequences captured built-in in real time. report feasibility implementation newly supported interactions. Through offline benchmarking 16-subject user study, we found that 1) is easy to learn, intuitive use, can serve an effective supplemental input...
Heart rate monitoring is widely used in clinical care, fitness training, and stress management. However, tracking individuals' heart rates faces two major challenges, namely equipment availability user motivation. In this paper, we present a novel technique, LivePulse Games (LPG), to measure users' real time by having them play games on unmodified mobile phones. With LPG, the calculated detecting changes transparency of fingertips via built-in camera device. More importantly, LPG integrate...
The use of Virtual Reality (VR) in applications such as data analysis, artistic creation, and clinical settings requires high precision input. However, the current design handheld controllers, where wrist rotation is primary input approach, does not exploit human fingers' capability for dexterous movements pointing selection. To address this issue, we investigated characteristics potential using a pen VR device. We conducted two studies. first examined which grip allowed largest range...