A5100374116- Optical measurement and interference techniques
- Video Surveillance and Tracking Methods
- Advanced Vision and Imaging
- Adaptive optics and wavefront sensing
- Psoriasis: Treatment and Pathogenesis
- Optical Systems and Laser Technology
- Human Pose and Action Recognition
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Generative Adversarial Networks and Image Synthesis
- Carbohydrate Chemistry and Synthesis
- Sulfur-Based Synthesis Techniques
- Face and Expression Recognition
- Immune Cell Function and Interaction
- Speech and Audio Processing
- Immune cells in cancer
- Robotics and Sensor-Based Localization
- Gait Recognition and Analysis
- Cyclopropane Reaction Mechanisms
- Infrared Target Detection Methodologies
- Fire Detection and Safety Systems
- Image Processing Techniques and Applications
- Remote-Sensing Image Classification
- Advanced Graph Neural Networks
- Asthma and respiratory diseases
National University of Singapore
2025
Nankai University
2025
Sichuan University
2012-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
State Key Laboratory of Biotherapy
2021-2024
Chuzhou University
2024
Nanjing University of Information Science and Technology
2023
Chinese Institute for Brain Research
2022
Capital Medical University
2022
Huawei Technologies (China)
2021
Abstract The intestinal microbiota has been associated with host immunity as well psoriasis; however, the mechanism of regulating psoriasis needs to be demonstrated systematically. Here, we sought examine its role and action in pathogenesis psoriasis. We found that severity psoriasis-like skin phenotype was accompanied by changes composition microbiota. performed co-housing fecal microbial transplantation (FMT) experiments using K14-VEGF transgenic mouse model transfer from mice severe...
The fundamental issue in immunotherapy is the lack of tumor-specific antigens most types tumors, leading to immune tolerance. For approximately 85% patients with microsatellite stable (MSS) colorectal cancer (CRC), absence tumor neoantigens results poor efficacy. Our previous study demonstrated that misincorporation non-proteinogenic proline (Pro) analog azetidine-2-carboxylic acid (AZE) could generate mutated proteins significantly enhance cell antigenicity and anti-tumor responses....
Here we report a simple and general method to achieve fully unprotected, stereoselective glycosylation of carboxylic acids, employing bench-stable allyl glycosyl sulfones as donors. Running the reaction under basic conditions was crucial for efficiencies selectivities. Both donor activation stage glycosidic bond forming process are compatible with free hydroxyl groups, thereby allowing use unprotected This transformation is stereoconvergent, occurs mild metal-free at ambient temperature...
Graphene oxide, a green and recyclable catalyst, was developed to synthesize 3-sulfenylindoles in water.
Abstract Interleukin-37b (hereafter called IL-37) was identified as fundamental inhibitor of natural and acquired immunity. The molecular mechanism function IL-37 in colorectal cancer (CRC) has been elusive. Here, we found that transgenic (IL-37tg) mice were highly susceptible to colitis-associated (CAC) suffered from dramatically increased tumor burdens colon. Nevertheless, is dispensable for intestinal mutagenesis, CRC cell proliferation, apoptosis, migration. Notably, dampened protective...
NoSQL databases have become increasingly popular due to their outstanding performance in handling large-scale, unstructured, and semi-structured data, highlighting the need for user-friendly interfaces bridge gap between non-technical users complex database queries. In this paper, we introduce Text-to-NoSQL task, which aims convert natural language queries into queries, thereby lowering technical barrier non-expert users. To promote research area, developed a novel automated dataset...
Abstract Defective execution of proteases and protease inhibitors that mediate abnormal signaling cascades is emerging as a key contributor to skin diseases, such psoriasis. SerpinB7 identified skin-specific endogenous inhibitor, but the role underlying mechanism in psoriasis are poorly understood. Here we found highly expressed psoriatic keratinocytes patients imiquimod-induced lesions mice. -/- mice showed epidermal barrier integrity architecture homeostasis, aggravated lesion with...
Regression testing is often performed with a time budget and it does not allow executing all test cases. Test case prioritization techniques re-order cases to increase the rate of fault detection. Several time-aware have been proposed satisfy budget. Since difficult collect cost each in some cases, natural question whether worth using such information when prioritizing In this paper, two most popular criteria: statement coverage detection are considered for prioritization. We investigate...
Based on the Legendre polynomials expressions and its properties, this article proposes a new approach to reconstruct distorted wavefront under test of laser beam over square area from phase difference data obtained by RSI system. And result simulation experimental results verifies reliability method proposed in paper. The formula error propagation coefficients is deduced when overlapping contain noise randomly. matrix T which can be used evaluate impact high-orders polynomial terms outcomes...
We present a modal wavefront reconstruction from slope measurements for rectangular optical components of high-power laser systems. Wavefront with data is an important approach used control or correction in In this work, we derive complete set orthonormal polynomials apertures and describe the method obtaining representation aberration balancing property. Error propagation properties are evaluated compared Southwell method. The cross-coupling error also discussed. Numerical experiments...
Abstract Interleukin 37 (IL‐37), a member of the IL‐1 family, is considered suppressor innate and adaptive immunity and, hence regulator tumor immunity. However, specific molecular mechanism role IL‐37 in skin cancer remain unclear. Here, we report that IL‐37b‐transgenic mice (IL‐37tg) treated with carcinogenic 7,12‐dimethylbenzoanthracene (DMBA)/12‐o‐tetradecylphorbol‐13‐acetate (TPA) exhibited enhanced increased burden by inhibiting function CD103 + dendritic cells (DCs). Notably, induced...
The C–H coupling of arenes with diazo-methylene-diphosphonates enables efficient synthesis new diphosphonates, which exhibit dual MBL and SBL inhibition.
A mild and recyclable protocol to synthesize 1,2-benzothiazines by Rh(III)-catalyzed C–H activation/cyclization of NH-sulfoximines in ionic liquids with high yields is described. broad substrate scope coupling partners applicable this method without any base or acid additives. The catalytic system, namely, Cp*Rh(III)/AgSbF6/[BMIM][PF6], still maintained good activity even after 10 cycles.
When existing deep learning models are used for road extraction tasks from high-resolution images, they easily affected by noise factors such as tree and building occlusion complex backgrounds, resulting in incomplete low accuracy. We propose the introduction of spatial channel attention modules to convolutional neural network ConvNeXt. Then, ConvNeXt is backbone network, which cooperates with perceptual analysis UPerNet, retains detection head semantic segmentation, builds a new model...
This paper proposes a new shearing approach to eliminate the systematic errors in phase measuring deflectometry (PMD). Besides normal measurement using PMD, another three measurements are taken when test surfaces translated and rotated with an amount of known magnitude our proposed method. The four give sheared wavefronts, then difference Zernike polynomial fitting least squares algorithm reconstruct true surface figure. method is demonstrated verified through computer simulation...
Psoriasis is a common chronic inflammatory skin disease mediated by innate and adaptive immune systems, characterized abnormal proliferation differentiation of epidermal keratinocytes infiltration cells. Skin-specific are key participants in immunity, responding to cells environmental stimulation, thereby serving an important role the immunopathogenesis psoriasis. Here, we present method for inducing psoriasiform inflammation at transcription level with HaCaT cell line using five...
Hematopoietic disorders are serious diseases that threaten human health, and the diagnosis of these is essential for treatment. However, traditional methods rely on manual operation, which time consuming laborious, examining entire slide challenging. In this study, we developed a weakly supervised deep learning method diagnosing malignant hematological requiring only slide-level labels. The improves efficiency by converting whole-slide image (WSI) patches into low-dimensional feature...
Diet is an important source of inflammation, and diet-induced inflammation might be associated with the etiopathogenesis psoriasis. This study aimed to explore relationship between dietary inflammatory index (DII), a literature-derived tool measure individual potential, incident was cross-sectional based on 2003-2006 2009-2014 National Health Nutrition Examination Surveys. The calculation DII 24-h recall. Psoriasis defined by self-reported medical questionnaire. Logistic regressions were...
One-shot 3D talking portrait generation aims to reconstruct a avatar from an unseen image, and then animate it with reference video or audio generate video. The existing methods fail simultaneously achieve the goals of accurate reconstruction stable face animation. Besides, while works mainly focus on synthesizing head part, is also vital natural torso background segments obtain realistic To address these limitations, we present Real3D-Potrait, framework that (1) improves one-shot power...