A5035983954- Cerebral Venous Sinus Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Blood Coagulation and Thrombosis Mechanisms
- Acute Ischemic Stroke Management
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Natural Language Processing Techniques
- Psoriasis: Treatment and Pathogenesis
- Ocular Oncology and Treatments
- Neurological disorders and treatments
- Retinal and Optic Conditions
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Retinoids in leukemia and cellular processes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autoimmune Neurological Disorders and Treatments
- Immune Response and Inflammation
- Neurological Complications and Syndromes
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Regulation of Appetite and Obesity
- Aortic Disease and Treatment Approaches
- Biochemical Analysis and Sensing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
Capital Medical University
2022-2025
Shanxi Academy of Medical Sciences
2025
Shanxi Medical University
2025
Northeast Forestry University
2024
China Pharmaceutical University
2024
Xuan Wu Hospital of the Capital Medical University
2023
Capital University
2023
Beihang University
2023
State Key Laboratory of Biotherapy
2021-2023
Sichuan University
2021-2023
Abstract Aims After myocardial infarction (MI), injured cardiomyocytes recruit neutrophils and monocytes/macrophages to myocardium, which in turn initiates inflammatory reparative cascades, respectively. Either insufficient or excessive inflammation impairs cardiac healing. As an endogenous inhibitor of neutrophil adhesion, EDIL3 plays a crucial role regulation. However, the MI remains obscure. We aimed define remodelling after MI. Methods results Serum levels patients were negatively...
Abstract Background and Purpose Cerebral venous thrombosis (CVT) is a special cerebrovascular disease that accounts for around 0.5%–1.0% of all strokes often occurs in younger adults. Intracranial hypertension the most frequent symptom acute CVT due to occlusion. This study aimed ascertain risk factors intracranial after investigate whether at diagnosis may affect patient outcomes. Methods We performed retrospective cohort analysis patients treated acute/subacute our department between 2018...
Abstract Defective execution of proteases and protease inhibitors that mediate abnormal signaling cascades is emerging as a key contributor to skin diseases, such psoriasis. SerpinB7 identified skin-specific endogenous inhibitor, but the role underlying mechanism in psoriasis are poorly understood. Here we found highly expressed psoriatic keratinocytes patients imiquimod-induced lesions mice. -/- mice showed epidermal barrier integrity architecture homeostasis, aggravated lesion with...
The relationship between urinary cadmium exposure levels and overactive bladder (OAB) has not been fully elucidated. purpose of this study was to further investigate the correlation OAB risk in adults. Laboratory data on were obtained from National Health Nutrition Examination Survey (NHANES) database for period 2007-2016. defined as Overactive Bladder Syndrome Symptom Score (OABSS, score ≥ 3) according International Continence Society. We used weighted logistic regression modelling assess...
Abstract Aims Cerebral venous thrombosis (CVT) is a major cause of stroke in young and middle‐aged adults. This study aimed to evaluate the prevalence post‐CVT employability decline identify factors associated with unemployment. Methods We identified patients first diagnosed acute/subacute CVT at Xuanwu Hospital, Capital Medical University (January 2018 June 2021) invited all survivors clinical 6‐months follow‐up visit after onset. Baseline data were collected from admission. A modified...
Abstract Interleukin 37 (IL‐37), a member of the IL‐1 family, is considered suppressor innate and adaptive immunity and, hence regulator tumor immunity. However, specific molecular mechanism role IL‐37 in skin cancer remain unclear. Here, we report that IL‐37b‐transgenic mice (IL‐37tg) treated with carcinogenic 7,12‐dimethylbenzoanthracene (DMBA)/12‐o‐tetradecylphorbol‐13‐acetate (TPA) exhibited enhanced increased burden by inhibiting function CD103 + dendritic cells (DCs). Notably, induced...
Abstract Background Brain function and neuronal activity depend on a constant supply of blood from the cerebral circulation. The venous system (CVS) contains approximately 70% total volume; similar to arterial system, CVS plays prominent role in maintenance central nervous (CNS) homeostasis. Impaired autoregulation, which can appear forms such as congestion, may lead metabolic abnormalities brain, causing severe functional defects even chronic tinnitus. However, congestion progression...
A new chemotype of ghrelin inverse agonists was discovered through chimeric design based on molecular scaffolds known as growth-hormone secretagogue receptor (GHSR) modulators but with divergent pharmacodynamic and pharmacokinetic properties. The structure-activities/properties exploration led to compound 47, which displayed potent human GHSR antagonism agonism in cellular assays (IC50 = 68 nM, EC50 29 nM), moderate oral bioavailability, notable brain penetration rat ( F 27%, B/ P ratio...
Psoriasis is a common chronic inflammatory skin disease mediated by innate and adaptive immune systems, characterized abnormal proliferation differentiation of epidermal keratinocytes infiltration cells. Skin-specific are key participants in immunity, responding to cells environmental stimulation, thereby serving an important role the immunopathogenesis psoriasis. Here, we present method for inducing psoriasiform inflammation at transcription level with HaCaT cell line using five...
Cerebral venous thrombosis (CVT) is a special and easily misdiagnosed or undiagnosed subtype of stroke. To identify specific biomarkers with high predictive ability for the diagnosis acute CVT, we performed metabolomic analysis in plasma samples from CVT patients healthy controls confirmed results validation cohorts. In discovery stage, there were 343 differential metabolites, caffeine metabolism pathway biosynthesis branched chain amino acids (BCAAs) valine, leucine, isoleucine two...
Purpose: Investigate the involvement of vascular endothelial growth factor receptor 1 (VEGFR1) in vasculogenic mimicry (VM) formation ocular melanoma, as well whether or not VEGFR1-targeted contrast-enhanced ultrasound (CEUS) can evaluate and quantify VM perfusion function melanoma model. Methods: The expression VEGFR1 was examined using immunofluorescence, western blot, quantitative polymerase chain reaction. networks were analyzed with tube periodic acid Schiff staining. Targeted...
The Coronavirus disease 2019 (COVID-19) epidemic has triggered a huge impact on healthcare, socioeconomics, and other aspects of the world over past three years. An increasing number studies have identified complex relationship between COVID-19 stroke, although active measures are being implemented to prevent transmission. Severe may be associated with an increased risk stroke increase rates disability mortality, posing serious challenge acute diagnosis, treatment, care. This review aims...
Abstract Background and purpose Cortical vein thrombosis (CVT) is a rare form of cerebral venous sinus (CVST) in adolescent patients that has received little attention. We aimed to analyze the clinical radiological features adolescents with CVST investigate effects CVT involvement. Methods Patients aged ≥ 10 ≤ 18 years diagnosed were identified at Xuanwu Hospital, Capital Medical University between January 2015 August 2022 divided into two groups according presence or absence cortical...
Background: The etiology and motor presentation differs between pediatric- adult-onset dystonia. Emerging evidence has demonstrated that non-motor symptoms are frequent in adult dystonia, which affect the quality of life. By contrast, little is known about frequency severity such presentations pediatric-onset individuals. Here, we investigated a large cohort Chinese patients with isolated dystonia compared groups. Methods: In this retrospective study, 34 197 were recruited. Motor impairment...
<title>Abstract</title> Psoriatic arthritis (PsA) is an immune-mediated, chronic inflammatory joint disease that commonly occurs as a complication of psoriasis. EGF-like repeats and discoidal I-like domain 3 (EDIL3) secreted protein with multiple structural domains associated various physiological functions. Mannan-induced psoriasis arthritis-like relies on the differentiation MoDCs Th17 cells. Reduced expression EDIL3 was correlated more severe symptoms in mannan-induced PsA. Additionally,...
Oracle bone script (OBS), as China's earliest mature writing system, present significant challenges in automatic recognition due to their complex pictographic structures and divergence from modern Chinese characters. We introduce OracleSage, a novel cross-modal framework that integrates hierarchical visual understanding with graph-based semantic reasoning. Specifically, we propose (1) Hierarchical Visual-Semantic Understanding module enables multi-granularity feature extraction through...
Recent studies show that large language models (LLMs) are powerful tools for working with natural language, bringing advances in many areas of computational linguistics. However, these face challenges when applied to low-resource languages due limited training data and difficulty understanding cultural nuances. In this paper, we propose QueEn, a novel approach Quechua-English translation combines Retrieval-Augmented Generation (RAG) parameter-efficient fine-tuning techniques. Our method...