A5000332889- Aquaculture disease management and microbiota
- CAR-T cell therapy research
- Invertebrate Immune Response Mechanisms
- Cancer Immunotherapy and Biomarkers
- Vibrio bacteria research studies
- Aquaculture Nutrition and Growth
- Immunotherapy and Immune Responses
- Crustacean biology and ecology
- Identification and Quantification in Food
- Insect symbiosis and bacterial influences
- Cancer Research and Treatments
- Occupational and environmental lung diseases
- Mosquito-borne diseases and control
- Genetic diversity and population structure
- Bacteriophages and microbial interactions
- Immune Cell Function and Interaction
- Parasite Biology and Host Interactions
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Marine Bivalve and Aquaculture Studies
- Myxozoan Parasites in Aquatic Species
- Bacterial biofilms and quorum sensing
- Neuroblastoma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- PARP inhibition in cancer therapy
Center for Cancer Research
2011-2025
Yangzhou University
2016-2025
National Institutes of Health
2012-2025
National Cancer Institute
2010-2025
Jiangsu Academy of Agricultural Sciences
2024
Hainan University
2024
Guangzhou University of Chinese Medicine
2023
Ocean University of China
2010-2017
Cancer Institute (WIA)
2015
Frederick National Laboratory for Cancer Research
2010-2014
Aeromonas veronii is a kind of opportunistic pathogen to fish and humans, significantly impending aquaculture production. Recently, we isolated two A. strains, named GYC1 GYC2, from diseased Gibel carp (Carassius gibelio) in China. Based on gyrB (DNA gyrase B subunit) genes the constructed phylogenetic tree showed that strains were clustered with veronii. Sixteen virulence related pathogenicity spp. subjected PCR assay. The ompAI, ompAII, lafA, act, aer, fla, gcaT acg detected while hly,...
BRCA1-associated protein-1 (BAP1), a nuclear deubiquitinase thought to be involved in DNA double-strand break repair, is frequently mutated mesothelioma. Because poly(adenosine diphosphate-ribose) polymerase inhibitors (PARPIs) induce synthetic lethality BRCA1/2 mutant cancers, we evaluated whether BAP1 inactivating mutations confer sensitivity PARPIs mesothelioma and if combination therapy with temozolomide (TMZ) would beneficial.A total of 10 patient-derived cell lines were generated...
Abstract Mesothelin targeting CAR T cells have limited activity in patients. In this study, we sought to determine if efficacy of anti-mesothelin is dependent on the mesothelin epitopes that are recognized by them. To do so, developed hYP218 (against membrane-proximal epitope) and SS1 membrane-distal cells. Their was assessed vitro using mesothelin-positive tumor cell lines vivo NSG mice with mesothelin-expressing ovarian cancer (OVCAR-8), pancreatic (KLM-1), mesothelioma patient-derived...
Aeromonas veronii is as an important opportunist pathogen of many aquatic animals, which wildly distributed in various environments. In this study, a dominant bacterium GJL1 isolated from diseased M. salmoides was identified A. according to the morphological, physiological, and biochemical characteristics, well molecular identification. Detection virulence genes showed isolate carried outer membrane protein A (ompA), flagellin (flgA, flgM, flgN), aerolysin (aer), cytolytic enterotoxin (act),...
mTOR is a central mediator of cancer cell growth, but it also directs immune differentiation and function. On this basis, we had explored the hypothesis that inhibition can enhance immunotherapy. Here, report combination αCD40 agonistic antibody ATP-competitive kinase inhibitory drug AZD8055 elicited synergistic antitumor responses in model metastatic renal carcinoma. In contrast to well-established inhibitor rapamycin, increased infiltration, activation, proliferation CD8(+) T cells natural...
Malignant mesothelioma is an aggressive cancer with limited treatment options and poor prognosis. A better understanding of genomics transcriptomics could advance therapies. Here, we present a cohort 122 patients along their germline tumor whole-exome RNA sequencing data as well phenotypic drug response information. We identify 48-gene prognostic signature that highly predictive patient survival, including CCNB1, the expression which survival on its own. In addition, analyze to study immune...
Abstract Human lung squamous cell carcinoma (SCC) is highly associated with increased pulmonary macrophage infiltration. Previously, we showed that marked infiltrating macrophages were required for spontaneous SCC development in a mouse model ( L-Ikkα KA/KA , ) resembles human SCC. Interestingly the SCC-associated specifically express elevated inducible nitric oxide synthase (NOS2). However, role of NOS2 carcinogenesis has not been explored. Here, show ablation inhibits infiltration,...
Mesothelin-targeted immunotoxin LMB-100 with anti–PD-1 antibody enhanced antitumor activity in patients mesothelioma and mouse tumor models.
Aeromonas veronii is widespread in aquatic environments and responsible for infecting various animals. In this study, a dominant strain was isolated from the hepatopancreas of diseased Macrobrachium rosenbergii named JDM1-1. According to its morphological, physiological, biochemical characteristics molecular identification, isolate JDM1-1 identified as A. veronii. The results artificial challenge showed had high pathogenicity M. with an LD50 value 8.35 × 105 CFU/mL during test....
Purpose: The purpose of this study was to evaluate the antitumor efficacy reduced immunogenicity anti-mesothelin immunotoxin RG7787 plus nab-paclitaxel against primary mesothelioma cell lines and tumor xenografts utility mesothelin as a biomarker response.Experimental Design: Early-passage human malignant NCI-Meso16, NCI-Meso19, NCI-Meso21, NCI-Meso29 were evaluated for sensitivity or alone in combination. In addition, activity using immunodeficient mice. Serum measured at different time...
Human induced pluripotent stem cells (iPSCs) offer a promising source for chimeric antigen receptor (CAR)–engineered natural killer (NK) products. However, complex iPSC-NK (iNK) manufacturing challenges clinical use. Here, we identified LiPSC-GR1.1 as superior iPSC line iNK production. By engineering with mesothelin (MSLN)–targeting CAR and interleukin-15 (IL-15), achieved robust differentiation of iPSCs into mature activated enhanced tumor killing efficacy, homing, vigorous proliferation....