A5101767163- Cardiac Ischemia and Reperfusion
- Chronic Myeloid Leukemia Treatments
- Autoimmune and Inflammatory Disorders Research
- Acute Lymphoblastic Leukemia research
- Heart Rate Variability and Autonomic Control
- Thyroid Disorders and Treatments
- Autophagy in Disease and Therapy
- Microtubule and mitosis dynamics
- Advanced Glycation End Products research
- Ocular Oncology and Treatments
- Cancer-related Molecular Pathways
- Neuroscience and Neuropharmacology Research
- Heart Failure Treatment and Management
- Thermal and Kinetic Analysis
- Adenosine and Purinergic Signaling
- Pericarditis and Cardiac Tamponade
- Sodium Intake and Health
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Pancreatic and Hepatic Oncology Research
- Inflammasome and immune disorders
- Liver Disease and Transplantation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hormonal Regulation and Hypertension
- Anesthesia and Neurotoxicity Research
Hunan Normal University
2023
Hunan Provincial People's Hospital
2023
Sichuan University
1997-2021
State Key Laboratory of Biotherapy
2020
West China Hospital of Sichuan University
2020
New York Medical College
2020
Fujian Medical University
2020
Jiaxing University
2018
Peking University
2015
Arkansas State University
2011
The precise mechanism through which macroautophagy/autophagy affects psoriasis is poorly understood. Here, we found that keratinocyte (KC) autophagy, was positively correlated with psoriatic severity in patients and mouse models could be inhibited by mitogen-activated protein kinase (MAPK) family inactivation. impairment of autophagic flux alleviated psoriasisform inflammation. We also an autophagy-based unconventional secretory pathway (autosecretion) dependent on ATG5 (autophagy related 5)...
Abstract Aims After myocardial infarction (MI), injured cardiomyocytes recruit neutrophils and monocytes/macrophages to myocardium, which in turn initiates inflammatory reparative cascades, respectively. Either insufficient or excessive inflammation impairs cardiac healing. As an endogenous inhibitor of neutrophil adhesion, EDIL3 plays a crucial role regulation. However, the MI remains obscure. We aimed define remodelling after MI. Methods results Serum levels patients were negatively...
Background/Aims: Renal ischemia/reperfusion injury (IRI) is a risk for acute renal failure and delayed graft function in transplantation cardiac surgery. The purpose of this study to determine whether propofol could attenuate IRI explore related mechanism. Methods: Male rat right kidney was removed, left subjected IRI. Propofol intravenously injected into rats before ischemia. morphology were analyzed. expression Bax, Bcl-2, caspase-3, cl-caspase-3, GRP78, CHOP caspase-12 detected by Western...
<b><i>Background/Aims:</i></b> Myocardial ischemia/reperfusion (I/R) injury (MI/RI) is a critical cause of death in patients with heart disease. However, the pharmaco-therapeutical outcome for MI/RI remains unsatisfactory. Innovative approaches enhancing drug sensitivity and recovering myocardial function treatment are urgently needed. The purpose this study was to evaluate protective effects exenatide-loaded poly(L-lysine)-poly(ethylene glycol)-poly(L-lysine)...
Backgrounds: High glucose (HG) caused oxidative stress and mitochondrial dysfunction, resulting in insulin resistance podocytes, a key mechanism of diabetic nephropathy. Dendrobium officinale polysaccharide (DOP) was able to improve antioxidant capability. Objective: The purpose this study is explore the by which DOP decreases podocyte injury induced HG. Methods: MPC5 cells were treated with HG, DOP, IRS-1/2 inhibitor NT157. Afterwards, consumption, generations ROS MDA measured using...
Background and purpose: Retinoblastoma is initiated by the mutation or loss inactivation of retinoblastoma gene (the Rb gene) in chromosome 13q14.Further, both germline cells (eggs sperm) generating individuals may carry a mutant allele so that mutants locus at embryo stage which case cancer tumor develop before birth.Recent molecular studies have also shown besides abrogation cell dierentiation locus, apoptosis mechanism needs to be inhibited abrogated for generation tumor.The purpose this...
To the Editor: Rheumatic diseases are disorders characterized by joint inflammation, but other organs also affected.[1] common in China, and clinical application of azathioprine (AZA), a purine analog immunosuppressant, for these is attracting increasing attention. Although AZA widely used treatment rheumatic diseases, its limited adverse effects, especially leukopenia. Thiopurine S-methyltransferase (TPMT) key enzyme metabolism thiopurines, including 6-mercaptopurine. Mutations TPMT gene...
Objective. In this study, we aimed to analyze thyroid function and related risk factors for dysfunction in 35 patients with Gitelman syndrome (GS). Methods. This study included GS who were referred West China Hospital of Sichuan University from Aug 2013 Jan 2018. General patient characteristics collected, was assessed. To evaluate the potential contribution hypokalemia dysfunction, 636 clinically diagnosed primary aldosteronism (PA) during same period as control group; these divided into a...
Azathioprine (AZA) is an immunosuppressive agent widely used in clinical therapy.However, the application of AZA restricted by its myelotoxicity.AZA-induced myelotoxicity varies greatly among patients, so it difficult to predict.In this study, untargeted metabolomics based on Ultra Performance Liquid Chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC Q-TOF/MS) was performed identify metabolite biomarkers for predicting AZA-induced Chinese rheumatological disease...
Objective: To investigate the role of short-term starvation (STS) in alleviating hepatic ischemia-reperfusion injury mice and possible mechanism action. Methods: Wild-type male C57BL/6 aged 8 weeks were randomly divided into 75% group (IR group), STS+75% (STS sirtinol+STS+75% (SIR using a random number table, sham-operation groups (IR-Sham group, STS-Sham SIR-Sham group) also established. The serum levels alanine aminotransferase (ALT) aspartate (AST) measured, histomorphological changes...
Hypertension (HTN) is a leading global noncommunicable cause of mortality and dietary salt the most common modifiable risk factor for HTN. Evidence suggests that tumor necrosis alpha (TNF-α) modulates mechanisms may contribute to salt-sensitive hypertension (SSHT). We conducted secondary analysis baseline cohort DASH-Sodium trial, explore relationship between TNF-α systolic blood pressure (SBP) in subjects categorized by race, sex, pressure. Urinary levels adjusted creatinine (pg/mg) were...