A5101500361- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- Food Quality and Safety Studies
- Pharmacogenetics and Drug Metabolism
- Phytoestrogen effects and research
- Chemical Synthesis and Analysis
- Advanced biosensing and bioanalysis techniques
- Phytochemicals and Antioxidant Activities
- Legume Nitrogen Fixing Symbiosis
- Free Radicals and Antioxidants
- Eicosanoids and Hypertension Pharmacology
- Phytochemistry and biological activity of medicinal plants
- Probiotics and Fermented Foods
- Sulfur-Based Synthesis Techniques
- Crystallography and molecular interactions
- Fluorine in Organic Chemistry
- Analytical Chemistry and Chromatography
- Tumors and Oncological Cases
- Biochemical Analysis and Sensing Techniques
- Carbohydrate Chemistry and Synthesis
- Aldose Reductase and Taurine
- melanin and skin pigmentation
- Teratomas and Epidermoid Cysts
Konkuk University
2025
Kyungpook National University
2003-2024
Dongguk University
2024
Gyeongsang National University
2023
University of California, Los Angeles
2017-2022
University of Kentucky
2020
Indonesia International Institute for Life Sciences
2020
Chungnam National University
2015-2018
Kangbuk Samsung Hospital
2018
Sungkyunkwan University
2018
Feeding behavior is influenced primarily by two factors: nutritional needs and food palatability. However, the role of deprivation metabolic in selection appropriate poorly understood. Here, we show that fruit fly, Drosophila melanogaster, selects calorie-rich foods following prolonged absence taste-receptor signaling. Flies mutant for sugar receptors Gr5a Gr64a cannot detect taste sugar, but still consumed over plain agar after 15 h starvation. Similarly, pox-neuro mutants are insensitive...
Two trigonal prismatic metallacages 1 and 2 bearing triphenylamine anthracene moieties are designed synthesized to fabricate artificial light-harvesting systems (LHSs). These two cages prepared via the coordination-driven self-assembly of anthracene-triphenylamine-based tripyridyl ligand 3, three dicarboxylates, six 90° Pt(II) acceptors. The design anthracene-triphenylamine chromophore makes possible tunable excited-state property (like emissive transition energy lifetime) as a function...
Here we report a nonenzymatic glycosylation reaction that builds axial S-glycosidic bonds under biorelevant conditions. This strategy is enabled by the design and use of allyl glycosyl sulfones as precursors to radicals exploits exceptional functional group tolerance radical processes. Our method introduces variety unprotected units cysteine residues peptides in highly selective fashion. Through developing second-generation protocol, applied our direct complex polypeptides proteins....
Nine anthraquinones, aurantio-obtusin (1), chryso-obtusin (2), obtusin (3), chryso-obtusin-2-O-β-D-glucoside (4), physcion (5), emodin (6), chrysophanol (7), obtusifolin (8), and obtusifolin-2-O-β-D-glucoside (9), isolated from an EtOAc-soluble extract of the seeds Cassia tora, were subjected to in vitro bioassays evaluate their inhibitory activity against advanced glycation end products (AGEs) formation rat lens aldose reductase (RLAR). Among isolates, compounds 6 8 exhibited a significant...
Two new flavan-3-ols, 6-(2-pyrrolidinone-5-yl)-(−)-epicatechin (1) and 8-(2-pyrrolidinone-5-yl)-(−)-epicatechin (2), as well five known compounds, (−)-epicatechin (3), (+)-catechin (4), proanthocyanidin B-4 (5), (+)-pinoresinol, p-hydroxybenzoic acid, were isolated from an EtOAc-soluble extract of the roots Actinidia arguta. The structures compounds 1 2 elucidated by spectroscopic data interpretation, particularly extensive 1D- 2D-NMR studies. All isolates evaluated in vitro for inhibitory...
A systematic study of arene-perfluoroarene interactions in solution is presented. Using a combination NMR titration experiments, X-ray crystallography, and computational analysis, we analyze the effects fluorination, substituents, ring size, solvation on interaction. We find that extension π systems, enhancement solvent polarity greatly stabilize stacking energy up to 3 orders magnitude (Ka = <1 6000 M–1), with highest Ka achieved for interaction water-soluble variants perfluoronaphthalene...
Lysine crotonylation (Kcr) is a histone post-translational modification that implicated in numerous epigenetic pathways and diseases. Recognition of Kcr by YEATS domains has been proposed to occur through intermolecular amide-π alkene-π interactions, but little known about the driving force these key interactions. Herein, we probed recognition lysine acetylation AF9 domain incorporation noncanonical Phe analogs with distinct electrostatics at two positions. We found interactions between...
A pH-sensitive dye-based freshness indicator has been developed to monitor the quality status of pork neck through distinct color transitions, addressing a crucial need for improved food safety and real-time monitoring within industry. This system aims boost consumer confidence improve shelf-life estimates by offering transparent immediate indicators. Aerobically packaged samples underwent accelerated testing at 25 °C 36 h, followed refrigeration experiments typical distribution temperatures...
This review discusses emerging strategies in three-component, stereoselective C–N bond-forming alkene difunctionalization, emphasizing mechanistic innovations and their impact on synthetic organic chemistry.
Trimethyllysine (Kme3) reader proteins are targets for inhibition due to their role in mediating gene expression. Although all such bind Kme3 an aromatic cage, the driving force binding may differ; some readers exhibit evidence cation-π interactions whereas others do not. We report a general unnatural amino acid mutagenesis approach quantify contribution of individual tyrosines cation using HP1 chromodomain as model system. demonstrate that two (Y24 and Y48) Kme3-histone tail peptide via...
Significance Iodine-induced cleavage is widely used for detecting bacterial DNA phosphorothioation in gel electrophoresis, deep sequencing, and single-molecule optical mapping. However, we lack quantitative understanding of the phosphorothioate (PT-DNA) efficiency chemoselectivity this method determination vs. phosphate. Computational explorations now reveal why iodine selectively attacks at sulfur links but not normal phosphates. The active role Tris buffer PT-DNA cleavage, factors...
Neglected tropical diseases (NTDs) affect over one billion people all the world. These are classified as neglected because they impact populations in areas with poor financial conditions and hence do not attract sufficient research investment. Human African Trypanosomiasis (HAT or sleeping sickness), caused by parasite Trypanosoma brucei, is of NTDs. The current therapeutic interventions for T. brucei infections often have toxic side effects require hospitalization so that available rural...
Four flavan-3-ols, (+)-catechin (1), 7-O-β-D-apiofuranoside (2), 7-O-β-D-xylopyranoside (3), 7-O-β-D-glucopyranoside (4), and proanthocyanidin A-1 (5) as well three other constituents, isolated from an EtOAc-soluble extract of the stem barks Ulmus davidiana var. japonica, were evaluated for inhibitory activity against formation AGEs. Compounds 1 – 5 exhibited a significant on AGEs in AGEs-BSA assay by specific fluorescence this was confirmed indirect AGEs-ELISA. Moreover, compounds markedly...
The aim of this study was to formulate probiotics-loaded pellets in a tablet form improve storage stability, acid tolerability, and vivo intestinal protective effect. Bacteria-loaded primarily prepared with hydroxypropyl methylcellulose acetate succinate were compressed into tablets highly compressible excipients optimized for flow properties, hardness, disintegration time. probiotic consisted enteric-coated (335 mg), microcrystalline cellulose (Avicel PH102, 37.5 porous calcium silicate (25...
The 4-anilino-6,7-ethylenedioxy-5-fluoroquinazoline scaffold is presented as a novel model system for the characterization of weak NH⋅⋅⋅F hydrogen bonding (HB) interaction. In this scaffold, aniline NH proton forced into close proximity with nearby fluorine (d