A5052095313- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Synthesis and Catalytic Reactions
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Chemical Synthesis and Reactions
- Electrocatalysts for Energy Conversion
- Catalytic Cross-Coupling Reactions
- Inorganic Fluorides and Related Compounds
- Cyclopropane Reaction Mechanisms
- Carbon dioxide utilization in catalysis
- Synthesis and Biological Evaluation
- Advanced battery technologies research
- DNA and Nucleic Acid Chemistry
- Chemical Synthesis and Analysis
- Catalytic Processes in Materials Science
- Electrochemical Analysis and Applications
- Nicotinic Acetylcholine Receptors Study
East China University of Science and Technology
2018-2025
Wuhan University
2013-2023
Argonne National Laboratory
2018
EarthTech International (United States)
2015-2016
Selectively free: A highly efficient and selective iron-catalyzed oxidative radical cross-coupling/cyclization to prepare dihydrobenzofurans under mild conditions had been established. Phenols olefins are directly utilized as clean nucleophiles. Mechanistic investigations revealed that the reaction proceeds through a pathway, high selectivity is due Lewis acid. As service our authors readers, this journal provides supporting information supplied by authors. Such materials peer reviewed may...
Herein, a fast, scalable, and transition-metal-free borylation of alkyl halides (X = I, Br, Cl) enabled by electroreduction is reported. This process provides an efficient practical access to primary, secondary, tertiary boronic esters at high current. More than 70 examples, including the late-stage natural products drug derivatives, are furnished room temperature, thereby demonstrating broad utility functional-group tolerance this protocol. Mechanistic studies disclosed that B2cat2 serves...
Electrochemistry has a lot of inherent advantages in organic synthesis and many redox reactions have been achieved under electrochemical condition. However, the C-C bond cleavage functionalization are less studied. Here we develop 1,3-difuntionalization arylcyclopropanes catalyst-free external-oxidant-free conditions. 1,3-difluorination, 1,3-oxyfluorination 1,3-dioxygenation with high chemo- regioselectivity by strategic choice nucleophiles. This protocol good functional groups tolerance can...
A visible light mediated radical C–H phosphorization of benzothiazoles with O<sub>2</sub> as the sole oxidant toward synthesis arylphosphonates was developed.
A novel strategy was developed to trigger ·CF3 by using in situ generated peroxide NMP under O2 or air as the radical initiator. Radical trifluoromethylation of alkenes achieved toward tertiary β-trifluoromethyl alcohols. Various alcohols can be synthesized good yields without extra oxidants transition metal catalysts. Preliminary mechanistic investigation revealed that diffusion influence reaction rate.
Low-cost transition metal oxides are actively explored as alternative materials to precious metal-based electrocatalysts for the challenging multistep oxygen evolution reaction (OER). We utilized Kirkendall effect allowing formation of hollow polycrystalline, highly disordered nanoparticles (NPs) synthesize active binary oxide OER in alkali media. Two synthetic strategies were applied achieve compositional control NPs. The first strategy is capitalized on oxidation transition-metal NP seeds...
An unprecedented single electron redox process in copper catalysis is confirmed using operando X-ray absorption and EPR spectroscopies. The oxidation state of the species interaction between Cu(II) a sulfinic acid at room temperature, accurate characterization formed Cu(I) are clearly shown evidence. Further investigation anion effects on discloses that bromine ions can dramatically increase rate process. Moreover, it proven acids converted into sulfonyl radicals, which be trapped by...
The efficient and selective C-H silylation of heteroarenes, especially the pharmaceutically relevant electron-deficient represents a great challenge in organic synthesis. Herein we wish to report distinctive visible light-promoted photocatalytic approach that enables direct coupling trialkylhydrosilanes with both -rich heteroarenes as well cyano-substituted arenes moderate high yields good regioselectivity. protocol features operational simplicity, mild reaction conditions, use safe readily...
The dioxygen-induced radical oxyphosphorylation of alkenes and alkynes is presented, wherein a P–H bond was activated by molecular oxygen.
Direct functionalization of inert C-H bonds is one the most attractive yet challenging strategies for constructing molecules in organic chemistry. Herein, we disclose an unprecedented and Earth abundant Cu/Cr catalytic system which unreactive alkyl are transformed into nucleophilic alkyl-Cr(III) species at room temperature, enabling carbonyl addition reactions with strong bonds. Various aryl alcohols furnished under mild reaction conditions even on a gram scale. Moreover, this new...
Difunctionalization of activated alkenes, a powerful strategy in chemical synthesis, has been accomplished for direct synthesis series β-keto sulfides and sulfones. The transformation, mediated by O2 , proceeds smoothly water without any catalyst. Prominent advantages this method include mild reaction conditions, purification simplicity, gram-scale underlining the practical utility methodology.
Direkt gekuppelt: Die Titelreaktion führt hoch effizient und selektiv unter milden Bedingungen zu Dihydrobenzofuranen. Mechanistische Untersuchungen deuten auf einen radikalischen Reaktionspfad hin; für die hohe Selektivität sorgt Lewis-Säure.
Abstract A copper‐catalyzed radical oxidative trifluoromethylation and arylation of electron‐withdrawing alkenes has been developed, in which economical sodium trifluoromethanesulfinate is used as the CF 3 source. preliminary kinetic investigation indicated that generation radicals under mild conditions might be a facile process.
An aerobic dehalogenative oxygenation reaction under mild and simple conditions towards a series of valuable β-keto compounds was developed, in which dioxygen serves as the sole promoter.
Spontaneous O<sub>2</sub> fixation by just mixing activated alkenes and thiols at room temperature is rationally demonstrated.
A hypervalent iodine(III)-mediated intramolecular decarboxylative Heck-type reaction of 2-vinyl-phenyl oxamic acids has been developed. The unique ring-strain-enabled radical decarboxylation mechanism is preliminarily revealed. This protocol features metal-free conditions and operational simplicity, allowing the lactamization 2-vinylanilines using a readily accessible carbonyl source synthesis various 2-quinolinones with excellent chemoselectivity at room temperature.
Abstract A copper‐catalyzed ketooxygenation of electron‐deficient alkenes was developed. This approach combines OH alkylation, aerobic decarboxylation, and oxygenation in one transformation. Mechanistic investigation this reaction showed that the copper salt is responsible for both generating amidoxyl radical promoting decarboxylation.
An m-CPBA-mediated intramolecular epoxidation-decarboxylative alkoxylation cascade reaction of olefinic oxamic acids has been developed. The distinct ionic decarboxylative mechanism was preliminarily revealed. protocol features mild conditions and operational simplicity, allowing the construction diverse medicinally valuable 5-7 membered 3D cyclic carbamate architectures in moderate to high yields.
Herein, a novel quinuclidine-promoted C-H silylation reaction using ammonium persulfate as the oxidant and hydrosilane silyl sourse was reported.The protocol proceeds via hydrogen atom transfer-based formation of radical features mild green conditions, operational-simplicity, relatively easy scale-up, broad substrate scope good functional group compatibility, providing powerful tool for facile introduction groups on electrondeficient nitrogen heteroarenes.Furthermore, in combination with...
Abstract Various β‐keto compounds such as (III) and (V) are obtained via an O 2 ‐mediated C(sp )—X bond oxygenation process without any external organic oxidant or metal catalyst.
Abstract A novel strategy is developed to trigger CF 3 radicals by using in situ generated peroxide NMP under O 2 or air as the radical initiator.