A5090998948- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Photodynamic Therapy Research Studies
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Fluorine in Organic Chemistry
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- Photoacoustic and Ultrasonic Imaging
- Luminescence and Fluorescent Materials
- Biosensors and Analytical Detection
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Catalysis and Hydrodesulfurization Studies
- Remote Sensing and Land Use
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Vitamin D Research Studies
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- Environmental and Agricultural Sciences
- Synthesis and Biological Evaluation
Southern Medical University
2011-2025
Sichuan University
2013-2025
University of Shanghai for Science and Technology
2018-2025
Guangdong Academy of Medical Sciences
2025
Guangdong Provincial People's Hospital
2025
Shanghai Normal University
2020-2025
Kunming Medical University
2025
Chengdu Medical College
2023-2024
Sichuan Normal University
2024
Chengdu Women's and Children's Central Hospital
2024
Although tumor mutation burden (TMB) has been well known to predict the response immune checkpoint inhibitors (ICI), lack of randomized clinical trial data restricted its application. This study aimed explore significance and feasibility biomarker combination based on TMB copy-number alteration (CNA) for prognosis each prediction ICI therapy in metastatic pan-cancer milieu.Non-ICI-treated MSK cohort was used analysis. Three independent immunotherapy cohorts, including non-small cell lung...
Phototheranostics based on upconversion nanoparticles (UCNPs) offer the integration of imaging diagnostics and phototherapeutics. However, programmable control photoactivation therapy with minimum side effects is challenging due to lack ideal switchable UCNPs agents. Here we demonstrate a facile strategy switch near infrared emission at 800 nm from rationally designed by modulating irradiation laser into pulse output. We further synthesize theranostic nanoagent combining photosensitizer...
Abstract Chemotherapy and radiotherapy predominantly improve the clinical outcomes of patients with human papillomavirus (HPV)-related head neck squamous cell carcinoma (HNSCC). Whether this superiority goes on when treated immune checkpoint inhibitors is still unclear. This study sought to determine predictive value potential mechanisms HPV status for treatment programmed death 1 (PD-1)/ligand 1(PD-L1) inhibitors. We conducted an integrated analysis relationships between PD-L1, tumor...
Abstract Due to its safety and efficacy, aluminum hydroxide is used as an immune adjuvant in human vaccines for over 80 years. Being a Th2 stimulator, the classical gel‐like adjuvant, however, fails generate CD8 + T cell responses, which are important cancer vaccines. Here, turned from gel into nano‐sized vaccine carriers AlO(OH)‐polymer nanoparticles (APNs) promote their lymphatic migration. After actively uptaken via scavenger receptor‐A by antigen‐presenting cells (APCs) resident lymph...
Here, we report a reversible photoacoustic (PA) probe, BDP-DOH, to image the localized redox state in vivo via monitoring dynamic changes of couple, superoxide anion (O2•–) and glutathione (GSH). The probe features significant shift absorption between 680 750 nm during selective oxidation with O2•– reductive recovery GSH, thus showing responsiveness intensity ratio (PA750/PA680) successfully visualize status tissue situ. This specific sensitive response provides potential technical tool...
Bladder cancer has become the most common malignant urinary carcinoma. Studies have shown that significant antioxidant and bladder cancer-fighting properties of several plant-based diets like Psidium guajava, ginger amomum, are associated with their high kaempferol content. In this paper, we evaluated anticancer activities its mechanism induction to apoptosis on cells. Our findings demonstrated showed an obvious radical scavenging activity in erythrocytes damaged by oxygen. Kaempferol...
Bone tumors, particularly osteosarcoma, are prevalent among children and adolescents. This ailment has emerged as the second most frequent cause of cancer-related mortality in Conventional treatment methods comprise extensive surgical resection, radiotherapy, chemotherapy. Consequently, management bone tumors regeneration poses significant clinical challenges. Photothermal tumor therapy attracted considerable attention owing to its minimal invasiveness high selectivity. However, key...
The antimicrobial resistance of Mycobacterium tuberculosis (M. tuberculosis) is a challenge in the antibiotic treatment (TB). Herein, we aimed to examine photodynamic therapy for TB that has low risk drug and involves biomimetic macrophage membranes combined with photosensitizer, chlorin e6 (Ce6; hereinafter, C-MV). We used marinum marinum), waterborne pathogen closely related M. tuberculosis, which causes TB-like infections ectotherms but not humans. mouse tail granuloma model induced by...
Abstract Background Protein kinase CK2 is a highly conserved, ubiquitous protein serine/threonine that phosphorylates many substrates and has global role in numerous biological pathological processes. Overexpression of the CK2α subunit (CK2α) been associated with malignant transformation several tissues, not nearly as much focus on colorectal cancer (CRC). The aims this study are to investigate function regulatory mechanism CRC development. Methods Expression levels were analyzed 144...
The carcinogenic activity of bisphenol A (BPA) is responsible for stimulating growth in estrogen-dependent breast cancer tissues, cell lines and rodent studies. However, it not fully understood how this compound promotes mammary carcinogenesis. In our study, we examined the effect BPA on cellular proliferation senescence human epithelial cells (HMEC). Exposure to 1 week at early stage passage 8 increased sphere size HMEC later up 16, suggesting that has capability modulate cells....
Microneedles (MNs) are micron-scale polymeric or metallic structures that offer distinct advantages for vaccines by efficiently targeting skin-resident immune cells, eliminating injection-associated pain, and improving patient compliance. These advantages, along with recent studies showing therapeutic benefits achieved using traditional intradermal injections in human cancer patients, suggest MN delivery might enhance immunotherapies. We recently developed a new class of polyelectrolyte...
Abstract Activatable type I photosensitizers are an effective way to overcome the insufficiency and imprecision of photodynamic therapy in treatment hypoxic tumors, however, incompletely inhibited photoactivity pro‐photosensitizer limited oxidative phototoxicity post‐photosensitizer major limitations. It is still a great challenge address these issues using single facile design. Herein, series totally caged pro‐photosensitizers (Pro‐I‐PSs) rationally developed that only activated tumor...
Emerging evidence indicates that the miR-17 family may have a causal role in human cancer tumorigenesis, but their specific effects on occurrence of CRC (colorectal carcinoma) are still poorly understood. In present study, we profiled tissue samples by miRNA (microRNA) microarray and found four members had higher expression tissues than normal tissues. This finding was further validated qRT-PCR (quantitative reverse transcription PCR). Transfecting cells with an inhibitor lowered ability to...
Divergent cyclizations of<italic>N</italic>-(2-(perfluoroalkyl)-3-alkynyl) hydroxylamines<bold>1</bold>have been realized by subtle choice of the catalyst under mild conditions, leading to two distinct types synthetic valuable compounds, cyclic nitrones<bold>2</bold>and pyrroles<bold>3</bold>, in moderate excellent yields.
Activatable theranostics, integrating high diagnostic accuracy and significant therapeutic effect, holds great potential for personalized cancer treatments; however, their chemodynamic modality is rarely exploited. Herein, we report a new in situ activatable theranostics PAsc/Fe@Cy7QB to specifically recognize eradicate cells with H2O2-catalyzed hydroxyl radical (•OH) burst cascade. Methods: The nanomicelles were constructed by self-assembly of acid-responsive copolymers incorporating...
To explore how strontium influences osteoclastogenesis and osteoblastogenesis during material-induced ectopic bone formation, porous strontium-substituted biphasic calcium phosphate (Sr-BCP) BCP ceramics with equivalent pore structures comparable grain size porosity were prepared. In vitro results showed that compared BCP, Sr-BCP inhibited the osteoclastic differentiation of osteoclast precursors by delaying cell fusion, down-regulating expression marker genes, reducing activity specific...