A5101790634- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Advanced Radiotherapy Techniques
- Breast Lesions and Carcinomas
- Lymphatic Disorders and Treatments
- Chemical Reactions and Isotopes
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- Multiple and Secondary Primary Cancers
- Microbial Metabolism and Applications
- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
Shantou Central Hospital
2011-2024
Southern Medical University
2011-2020
Nanfang Hospital
2011-2020
Second Affiliated Hospital of Zhengzhou University
2017
Zhengzhou University
2017
Sun Yat-sen University
2016
Shantou University
2016
Abstract Background Protein kinase CK2 is a highly conserved, ubiquitous protein serine/threonine that phosphorylates many substrates and has global role in numerous biological pathological processes. Overexpression of the CK2α subunit (CK2α) been associated with malignant transformation several tissues, not nearly as much focus on colorectal cancer (CRC). The aims this study are to investigate function regulatory mechanism CRC development. Methods Expression levels were analyzed 144...
Background Genetic variations of some driver genes in non-small cell lung cancer (NSCLC) had shown potential impact on immune microenvironment and associated with response or resistance to programmed death protein 1 (PD-1) blockade immunotherapy. We therefore undertook an exploratory analysis develop a genomic mutation signature (GMS) predict the anti-PD-(L)1 therapy. Methods In this multicohort analysis, 316 patients non-squamous NSCLC treated from three independent cohorts were included...
Emerging evidence indicates that the miR-17 family may have a causal role in human cancer tumorigenesis, but their specific effects on occurrence of CRC (colorectal carcinoma) are still poorly understood. In present study, we profiled tissue samples by miRNA (microRNA) microarray and found four members had higher expression tissues than normal tissues. This finding was further validated qRT-PCR (quantitative reverse transcription PCR). Transfecting cells with an inhibitor lowered ability to...
Abstract Purpose To develop and validate a nomogram model to predict complete response (CR) after concurrent chemoradiotherapy (CCRT) in esophageal squamous cell carcinoma (ESCC) patients using pretreatment CT radiomic features. Methods Data of diagnosed as ESCC treated with CCRT Shantou Central Hospital during the period from January 2013 December 2015 were retrospectively collected. Eligible included this study randomize divided into training set validation successive screening. The least...
To develop a nomogram model for predicting local progress-free survival (LPFS) in esophageal squamous cell carcinoma (ESCC) patients treated with concurrent chemo-radiotherapy (CCRT). We collected the clinical data of ESCC CCRT our hospital. Eligible were randomly divided into training cohort and validation cohort. The least absolute shrinkage selection operator (LASSO) COX regression was performed to select optimal radiomic features calculate Rad-score LPFS univariate multivariate analyses...
The impact of sex on prognosis patients with esophageal squamous cell cancer (ESCC) who underwent definitive radiotherapy remained unclear. present study aimed to determine the ESCC radiotherapy.Between January 2009 and December 2015, in Shantou Central Hospital were included this study. Progression-free survival (PFS) overall (OS) rates estimated using Kaplan-Meier method. PFS OS compared between female male patients. Cox regression model was used identify prognostic factors. Propensity...
Abstract Background RhoE is an atypical member of Rho GTPases family, which a crucial regulator cytoskeletal dynamics, cell cycle progression, and proliferation. Previous studies have reported that was aberrantly expressed in several human cancers, but the role hepatocellular carcinoma (HCC) remained poor understood. Objectives This study investigated expression its clinical significance on outcome patients with HCC. Methods The examined HCC then prognostic impact status evaluated by...
Definitive chemoradiotherapy (dCRT) is a treatment option for patients with localized esophageal squamous cell carcinoma (ESCC). We investigated consolidation chemotherapy (CCT) in ESCC who attained clinical complete response after dCRT. Between January 2009 and December 2012, medical records of treated dCRT were retrospectively reviewed, those CCR identified. Progression-free survival overall rates estimated by the Kaplan-Meier method. The Cox regression model was used to determine...
Background: This present study aimed to explore the prognostic value of pretreatment neutrophil and lactate dehydrogenase (LDH) develop a risk scoring model predict prognosis in esophageal squamous cell cancer (ESCC) patients treated with definitive radiotherapy. Methods: Retrospectively collected data who received radiotherapy for ESCC at Shantou Central Hospital between January 2009 December 2015 were included analysis. The association level LDH clinicopathological characteristics...
The aim of this work was to evaluate the prognostic value tumor length and diameter for patients with esophageal squamous cell cancer (ESCC) treated definitive (chemo)radiotherapy identify potential indicators separate nonsurgical T staging, which are needed in clinical practice.A total 682 ESCC who underwent between 2009 2015 were reviewed. Esophageal determined by barium esophagography computed tomography before treatment. Univariate multivariate analyses used assess impact on long-term...
Up to 17% of cancer survivors have been reported develop second primary cancers (SPC), which cause significant physical and economic distress often complicate clinical decision-making. However, understanding SPC remains limited superficial. Human leukocyte antigen (HLA) is characterized by its polymorphism has associated with various diseases. This study aims explore the role HLA diversity in incidence.
The prognostic value of supra-clavicular lymph node (SCLN) metastases in esophageal cancer (EC) is still not clear. From January 2009 to December 2015, a survival analysis was performed retrospectively identify the SCLN metastasis on 751 patients with EC treated definitive chemo-radiotherapy (dCRT). median follow-up duration for living 56.6 months. overall (OS) all 16.6 Patients had much poorer prognosis OS (χ2 = 17.342, P < 0.001), distant metastasis-free (DMFS) 24.793, 0.001) and...
To estimate efficacy of checkpoint inhibitors and rank treatment effects in non-small-cell lung cancer.Prospective randomized trials were included. p-score was used to effects.A total nine identified, involving 5504 patients three inhibitors. Pembrolizumab plus chemotherapy had the highest 0.95 among all treatments, superior pembrolizumab alone (hazard ratio: 0.87; 95% CI: 0.79-0.95). Combination therapy more grade 3-5 adverse events; but toxicity-related discontinuation treatment-related...
Abstract Purpose To develop and validate a nomogram model to predict complete response (CR) after concurrent chemoradiotherapy (CCRT) in esophageal squamous cell carcinoma (ESCC) patients using pretreatment CT radiomic features. Methods Data of diagnosed as ESCC treated with CCRT Shantou Central Hospital during the period from January 2013 December 2015 were retrospectively collected. Eligible included this study randomize divided into training set validation successive screening. The least...
Abstract Purpose: To develop and validate a nomogram model to predict complete response (CR) after concurrent chemoradiotherapy (CCRT) in esophageal squamous cell carcinoma (ESCC) patients using pretreatment CT radiomic features. Methods: Data of diagnosed as ESCC treated with CCRT Shantou Central Hospital during the period from January 2013 December 2015 were retrospectively collected. Eligible included this study randomize divided into training set validation successive screening. The...
To compare overall survival in patients with clinical T1-3N0-1 thoracic esophageal squamous cell carcinoma treated surgery or definitive chemoradiation therapy (CRT).We used propensity-score matching to derive 1:1 cohorts of versus CRT. Statistical analysis was performed using χ2 Fisher's exact tests. Survival functions were estimated Kaplan-Meier plots, and distributions compared log-rank Cox proportional hazards modeling analyze the factors affecting survival.A total 334 252 CRT included....