A5101506693- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Nuclear reactor physics and engineering
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Nuclear Materials and Properties
- Nuclear Physics and Applications
- Brain Metastases and Treatment
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- Magnetic confinement fusion research
- Colorectal Cancer Treatments and Studies
- Membrane Separation Technologies
- Pancreatic and Hepatic Oncology Research
- Sepsis Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Membrane Separation and Gas Transport
- Ovarian function and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Solar-Powered Water Purification Methods
- Cardiac Arrest and Resuscitation
- Magnesium Alloys: Properties and Applications
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
Zigong First People's Hospital
2025
University of Hong Kong
2023-2024
Chengdu Women's and Children's Central Hospital
2022-2024
Chengdu Medical College
2022-2024
Central South University
2023-2024
Chongqing University
2022-2024
Second Xiangya Hospital of Central South University
2023-2024
Chongqing Public Health Medical Center
2022-2024
Sichuan University
2022-2024
Southern Medical University
2024
T cell infiltration into white adipose tissue (WAT) drives obesity-induced inflammation, but the mechanisms of WAT remain unclear. Our single-cell RNA sequencing reveals a significant impact stem cells (ASCs) on cells. Transplanting ASCs from obese mice enhances accumulation. C-C motif chemokine ligand 5 (CCL5) is upregulated in as early 4 weeks high-fat diet feeding, coinciding with onset during obesity. and bone marrow transplantation experiments demonstrate that CCL5 plays crucial role...
Accumulation and activation of immunocytes in adipose tissues are essential to obesity-induced inflammation insulin resistance. Chemokines pivotal for the recruitment tissue during obesity. Chemokine (C-C motif) ligand 5 (CCL5) plays a vital role sites inflammation. CCL5 expression level is increased obese from humans mice. However, remains unclear. Our study found that was epididymal white (eWAT) mice, particularly CD8 + T cells. knockout (KO) mice exhibited better glucose tolerance than...
This study was aimed at examining the causes of death (CODs) in patients with advanced intrahepatic cholangiocarcinoma (ICC) undergoing chemotherapy (CT). In addition, machine learning models were incorporated to predict treatment outcomes ICC and identify factors most closely related prognosis. A total 5564 (CT group, 3632; non-CT 1932) included Surveillance Epidemiology End Results registries between 2000 2020. The CODs compared two groups before after inverse probability weighting (IPTW)....
It is currently a challenge to accurately predict the deformation and fracture behavior of metal parts in automobile crashes. Many studies have shown that materials are significantly affected by stress state during crashes with complex characteristics. In order further promote application die-cast magnesium alloys automobiles, it particularly important study material alloys. this paper, mechanical properties AM60B alloy sheet under four states (shear, tension, R10 notch cupping) were...
Ten-eleven translocation (TET) 2 is an enzyme that catalyzes DNA demethylation to regulate gene expression by oxidizing 5-methylcytosine 5-hydroxymethylcytosine, functioning as essential epigenetic regulator in various biological processes. However, the regulation and function of TET2 adipocytes during obesity are poorly understood. In this study, we demonstrate leptin, a key adipokine mammalian energy homeostasis regulation, suppresses adipocyte levels via JAK2-STAT3 signaling. Adipocyte...
The most appropriate alternative to induction therapy for HIV-associated cryptococcal meningitis (CM) remains unclear when standard treatment is unavailable, inaccessible, intolerable, or ineffective.
Regardless of its anatomical site, adipose tissue shares a common energy-storage role but exhibits distinctive properties. Exploring the cellular and molecular heterogeneity white (WAT) is crucial for comprehending function However, existing single-nucleus RNA sequencing (snRNA-seq) studies have examined only one or two depots. In this study, we employed snRNA-seq to test five representative depots including inguinal, epididymal, mesenteric, perirenal, pericardial tissues in mice under...
A series of experiments were conducted to study the effect obstacle on evacuation efficiency mice under different competitive condition. Firstly, low The drove escape in two typical settings. Setting I is an area 1.5m wide and long II a laterally constrained area. For both conditions, tests with without impact evacuation. At setting I, average time 305s 298s respectively for non-obstacle condition II, 313s Under condition, presence has little Secondly, same high 334s 297s mean 328s reduces...
Abstract Background China is a country burdened with high incidence of both tuberculosis (TB) and HIV, Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) an important early complication in TB HIV co-infected patients, but data from are limited. Additionally, as integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) regimen becomes the first-line treatment, concerns have arisen regarding potential increase paradoxical TB-IRIS....
Up to 17% of cancer survivors have been reported develop second primary cancers (SPC), which cause significant physical and economic distress often complicate clinical decision-making. However, understanding SPC remains limited superficial. Human leukocyte antigen (HLA) is characterized by its polymorphism has associated with various diseases. This study aims explore the role HLA diversity in incidence.
Abstract Background Vitrectomy and peeling of the internal limiting membrane (ILM) was an effective therapeutic approach for myopic foveoschisis with progressive visual loss. This study investigated anatomical outcomes fovea-sparing ILM or without inverted flap technique patients symptomatic (MF). Methods We retrospectively reviewed clinical data MF. air tamponade performed in all patients. The primary outcome measures included best-corrected acuity (BCVA), mean macular thickness (MMT),...
HENDL2.0, the latest version of hybrid evaluated nuclear data library, was developed based upon some from FENDL2.1 and ENDF/B-VII. To qualify validate working an integral test for neutron production HENDL2.0 performed with a series existing spherical shell benchmark experiments (such as V, Be, Fe, Pb, Cr, Mn, Cu, Al, Si, Co, Zr, Nb, Mo, W Ti). These were simulated numerically using HENDL2.0/MG home-developed code VisualBUS. Calculations conducted both FENDL2.1/MG FENDL2.1/MC, which are on...
Ovarian tissue cryopreservation is effective in preserving fertility cancer patients who have concerns about loss due to treatment. However, ischemia reduces the lifespan of grafts. Microvascular transplantation cryopreserved whole ovary may allow immediate revascularisation, but damage incurred during procedure cause follicular depletion; hence, preventing chilling injury would help maintain ovarian function.This study was designed investigate beneficial effects antifreeze protein III (AFP...
BackgroundPrevious studies have suggested that point-of-care ultrasound could help to evaluate and diagnose pediatric skull fracture for the closed scalp hematoma from blunt trauma. However, relevant data in Chinese children are missing, especially 0–6 years old.ObjectivesOur study aimed efficacy of old with China.MethodsWe performed a prospective observational screened Glasgow coma scale 14–15 at Hospital China. Enrolled (N = 152) were first evaluated by emergency physician then received...