A5061151592- HIV Research and Treatment
- Fungal Infections and Studies
- HIV/AIDS Research and Interventions
- Antifungal resistance and susceptibility
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Tuberculosis Research and Epidemiology
- HIV, Drug Use, Sexual Risk
- Mycobacterium research and diagnosis
- Cytomegalovirus and herpesvirus research
- Gut microbiota and health
- Nail Diseases and Treatments
- Toxoplasma gondii Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Mosquito-borne diseases and control
- COVID-19 Impact on Reproduction
- COVID-19 and Mental Health
- HIV/AIDS oral health manifestations
- Diagnosis and treatment of tuberculosis
Chongqing Public Health Medical Center
2016-2025
Zunyi Medical University
2018-2023
Southwest University
2020-2023
Weatherford College
2020
Creative Commons
2020
Beijing YouAn Hospital
2019-2020
Guangxi Longtan Hospital
2020
Chongqing Medical University
2020
Chongqing Emergency Medical Center
2020
Capital Medical University
2019-2020
According to the World Health Organization (WHO) newly updated situation report on March 18th, 2020, coronavirus disease 2019 (COVID-19) pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide. 16][7][8] Although mortality rate of COVID-19 is significantly lower than that SARS-CoV infection, SARS-CoV-2 shows much higher human-to-human transmission rate, rapidly leading a global declared by WHO 11th, 2020. 9 Currently, there are no approved prophylactic vaccines or therapeutic...
Abstract Background A pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has been spreading over the world. However, viral dynamics, host serologic responses, and their associations with clinical manifestations, have not well described in prospective cohort. Methods We conducted a cohort enrolled 67 COVID-19 patients admitting between Jan 26 Feb 5, 2020. Clinical specimens including nasopharyngeal swab, sputum, blood, urine stool were...
COVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection. It is currently unknown as to the correlation between magnitude of neutralizing antibody (NAb) responses and in patients. In a cohort 59 recovered with including severe, moderate, mild, asymptomatic, we observed positive serum capacity severity, particular, highest NAb sera from severe disease, while lack ability asymptomatic mount competent NAbs. Furthermore, compositions subtypes were also different...
Coronavirus disease 2019 (COVID-19), which emerged in Wuhan, China December 2019, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has become a major global public h...
Salidroside, a natural active ingredient extracted from Rhodiola rosea, has been shown to exert antitumor activity against breast cancer Dong Young et al. [1], colon Sun [2] and bladder Tian [3]. However, the effect of salidroside on apoptosis autophagy in gastric remains unclear. In our research, we observed biological human AGS cells. Our results demonstrated that inhibited growth cells both vivo vitro exerted proapoptotic as confirmed by flow cytometry, Hoechst staining western blot...
Abstract Background We aim to investigate the profile of acute antibody response in COVID-19 patients, and provide proposals for usage test clinical practice. Methods A multi-center cross-section study (285 patients) a single-center follow-up (63 were performed feature SARS-CoV-2. cohort 52 suspects 64 close contacts enrolled evaluate potentiality test. Results The positive rate IgG reached 100% around 20 days after symptoms onset. median day seroconversion both lgG IgM was 13 Seroconversion...
Abstract Background: At the end of 2019, a novel coronavirus outbreak causative organism has been subsequently designated 2019 (2019-nCoV). The effectiveness adjunctive glucocorticoid therapy in management 2019-nCoV-infected patients with severe lower respiratory tract infections is not clear, and warrants further investigation. Methods: present study will be conducted as an open-labeled, randomized, controlled trial. We enrol 48 subjects from Chongqing Public Health Medical Center. Each...
In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features immunological profile of COVID-19 paediatrics. The treatment outcomes twelve paediatric patients confirmed as were analyzed. children was investigated compared with twenty adult patients. median age 14.5-years (range from 0.64 to 17), six male. average incubation period 8 days. Clinically, cough (9/12,...
Abstract Background In January 19, 2020, first case of 2019 novel coronavirus (2019-nCoV) pneumonia (COVID-19) was confirmed in Chongqing municipality, China. Methods this retrospective, descriptive, multiple-center study, total 267 patients with COVID-19 by real-time RT-PCR from Jan 19 to Feb 16, 2020 were recruited. Epidemiological, demographic, clinical, radiological characteristics, laboratory examinations, and treatment regimens collected on admission. Clinical outcomes followed up...
The dynamics of quasispecies afford RNA viruses a great fitness on cell tropism and host range. To study the features intra-host evolution SARS-CoV-2, we collected nine confirmed patients sequenced haplotypes spike gene using single-molecule real-time platform. Fourteen samples were extracted from sputum, nasopharyngeal swabs, or stool, which in total produced 283,655 high-quality circular consensus sequences. We observed stable structure that one master mutant (mean abundance ∼0.70),...
Candida albicans (C. albicans) is a ubiquitous fungal commensal component of the human microbiota, and under certain circumstances, such as during an immunocompromised state, it may initiate different types infection. Moreover, C. continuously reciprocally interacts with host immune system well other elements gut thus contributing significantly to both homeostasis immunity. People living HIV (PLWH), including those receiving antiretroviral therapy, are characterized by depletion CD4 +...
Abstract Tumor-specific T cells are crucial in anti-tumor immunity and act as targets for cancer immunotherapies. However, these numerically scarce functionally exhausted the tumor microenvironment (TME), leading to inefficacious immunotherapies most patients with cancer. By contrast, emerging evidence suggested that tumor-irrelevant bystander (T BYS ) abundant preserve functional memory properties TME. To leverage TME eliminate cells, we engineered oncolytic virus (OV) encoding epitopes...
To the Editor: At end of 2019, an outbreak novel coronavirus disease 2019 (COVID-19), caused by 2019-nCov, causing widespread disease. This COVID-19 occurred during period 2020 Spring Festival in China, a known for massive population movements within China. has resulted large numbers infected patients as consequence multiple human contact episodes individual travelers. The 2019-nCov is genetically similar to severe acute respiratory syndrome (SARS-CoV) and Middle East (MERS-CoV), which also...
Currently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, causing an unprecedented pandemic. However, there is no specific antiviral therapy for disease 2019 (COVID-19). We conducted a clinical trial to compare the effectiveness of three treatment regimens in patients with mild moderate COVID-19.This was single-center, randomized, open-labeled, prospective trial. Eligible COVID-19 were randomized into groups: ribavirin (RBV) plus interferon-α (IFN-α),...
Convalescent plasma (CP) transfusion has been indicated as a promising therapy in the treatment for other emerging viral infections. However, quality control of CP and individual variation patients different studies make it rather difficult to evaluate efficacy risk coronavirus disease 2019 (COVID-19). We aimed explore potential therapy, assess possible factors associated with its efficacy. enrolled eight critical or severe COVID-19 from four centers. Each patient was transfused 200-400 mL...