A5100615605- RNA modifications and cancer
- Legume Nitrogen Fixing Symbiosis
- Soybean genetics and cultivation
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
- Metalloenzymes and iron-sulfur proteins
- Advanced Nanomaterials in Catalysis
- Plant Growth Enhancement Techniques
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Electrocatalysts for Energy Conversion
- Electrochemical sensors and biosensors
- Wastewater Treatment and Nitrogen Removal
- Leaf Properties and Growth Measurement
- Anaerobic Digestion and Biogas Production
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nematode management and characterization studies
- NF-κB Signaling Pathways
First Affiliated Hospital of Kunming Medical University
2025
Kunming Medical University
2025
The University of Sydney
2024-2025
University of South China
2022-2024
Tsinghua University
2015-2024
Tsinghua–Berkeley Shenzhen Institute
2019-2024
Shandong Agricultural University
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
University of Victoria
2024
First Affiliated Hospital of Xi'an Jiaotong University
2021-2024
Purpose To determine the accuracy, reproducibility, and intra- interobserver agreement of a computer-based quantitative method to measure liver surface nodularity (LSN) from routine computed tomographic (CT) images as biomarker for detection evaluation cirrhosis. Materials Methods For this institutional review board-approved HIPAA-compliant retrospective study, adult patients with healthy livers (n = 24) or various stages hepatitis C virus-induced chronic disease 70) nonenhanced portal...
Abstract Appendectomy impacts the homeostasis of gut microbiome in patients. We aimed to study role appendectomy colorectal cancer (CRC) risk through causing microbial dysbiosis. Population-based longitudinal (cohort 1, n = 129,155) showed a 73.0% increase CRC among cases throughout 20 years follow-up (Adjusted sub-distribution hazard ratio (SHR) 1.73, 95% CI 1.49–2.01, P < 0.001). Shotgun metagenomic sequencing was performed on fecal samples from cohort 2 ( 314). Gut dysbiosis subjects...
T cell infiltration into white adipose tissue (WAT) drives obesity-induced inflammation, but the mechanisms of WAT remain unclear. Our single-cell RNA sequencing reveals a significant impact stem cells (ASCs) on cells. Transplanting ASCs from obese mice enhances accumulation. C-C motif chemokine ligand 5 (CCL5) is upregulated in as early 4 weeks high-fat diet feeding, coinciding with onset during obesity. and bone marrow transplantation experiments demonstrate that CCL5 plays crucial role...
Cu catalyses electrochemical CO2 reduction to valuable multicarbon products but understanding the structure-function relationship has remained elusive due active sites being heterogenized and under dynamic re-construction during electrolysis. We herein coordinate with six phenyl-1H-1,2,3-triazole derivatives form stable coordination polymer catalysts homogenized, single-site sites. Electronic structure modelling, X-ray absorption spectroscopy, ultraviolet–visible spectroscopy show a widely...
Diazotrophic bacteria can reduce N2 into plant-available ammonium (NH4+), promoting plant growth and reducing nitrogen (N) fertilizer requirements. However, there are few systematic studies on the effects of diazotrophic biological fixation (BNF) contribution rate host N uptake metabolism. In this study, interactions Paenibacillus beijingensis BJ-18 with wheat, maize, cucumber were investigated when it was inoculated to these seedlings grown in both low high soils, un-inoculated plants as...
Artemeriopolides A–D (1–4), four novel cadinane sesquiterpenoid dimers featuring the rare 2-oxaspiro[4.6]undecan-1,7-dione, 2-oxaspiro[4.5]decan-1-one, and 2-oxaspiro[5.5]undecan-1-one ring systems, were isolated from Artemisia eriopoda .
OBJECTIVE. The objective of our study was to evaluate outcomes and complications related the management Bosniak category IIF, III, IV renal cysts.
Biofertilizer is a good substitute for chemical fertilizer in sustainable agriculture, but its effects are often hindered by drought stress. Super absorbent polymer (SAP), showing capacity of water absorption and retention, can increase soil moisture. However, limited information available about the efficiency biofertilizer amended with SAP. This study was conducted to investigate synergistic application SAP biofertilizers (Paenibacillus beijingensis BJ-18 Bacillus sp. L-56) on plant growth,...
Instant dark tea (IDT) is a new product gaining increasing attention because it convenient and can endow significant health benefit to consumers, which partially attributed its high concentration of functional ingredients. However, the molecular mechanism underlying regulatory effect on hyperlipidaemia rarely studied. In this study, we performed omics verification in high-fat diet (HFD)-fed rat, aiming reveal provide evidence. The results showed that major bioactive components IDT were 237.9...
Recent studies show that multi-modal data fusion techniques combine information from diverse sources for comprehensive diagnosis and prognosis of complex brain disorder, often resulting in improved accuracy compared to single-modality approaches. However, many existing methods extract features homogeneous networs, ignoring heterogeneous structural among multiple modalities. To this end, we propose a Hypergraph-based Multi-modal Fusion algorithm, namely HMF. Specifically, first generate...
344 Background: To evaluate outcomes, complications and costs associated with management of Bosniak IIF, III, IV cystic renal lesions/malignancies. Methods: An IRB-approved HIPAA-compliant multi-institutional retrospective data registry prospectively classified IIF (N=143), III (N=114), (N=29) lesions diagnosed in adults between January 2000 October 2011 at UMMC, UAB, or WFUBMC was performed. Included patients were managed by surgical excision (N=86), ablation (N=19), imaging-surveillance...
Numerous herbal-derived natural products are excellent anti-inflammatory agents. Several studies have reported that aloin, the major anthraquinone glycoside obtained from Aloe species, exhibits activity. However, molecular mechanism of this activity is not well understood. In report, we found aloin suppresses lipopolysaccharide-induced pro-inflammatory cytokine secretion and nitric oxide production, downregulates expression tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), inducible...
Pancreatic β cell damage is the primary contributor to type 2 diabetes mellitus (T2DM); however, underlying mechanism remains nebulous. This study explored role of ferroptosis in pancreatic and protective effects grape seed proanthocyanidin extract (GSPE). In T2DM model rats, blood glucose, water intake, urine volume, HbA1c, homeostasis assessment-insulin resistance were significantly increased, while body weight insulin level decreased, indicating successful establishment model. MIN6 mouse...
CELF6, a member of the CELF family RNA-binding proteins, regulates muscle-specific alternative splicing and contributes to pathogenesis myotonic dystrophy (DM), however role CELF6 in cancer cell proliferation is less appreciated. Here, we show that expression cycle regulated. The cycle-dependent mediated through ubiquitin-proteasome pathway, SCF-β-TrCP recognizes nonphospho motif its proteasomal degradation. Overexpression or depletion modulates p21 gene expression. binds 3'UTR transcript...
Disrupting the interaction between HIF1α and p300 is a promising strategy to modulate hypoxia response of tumor cells. Herein, we designed constrained peptide inhibitor derived from CITED2/p300 complex disturb HIF1α/p300 interaction. Through truncation/mutation screening terminal aspartic acid-stabilized strategy, was constructed with outstanding biochemical/biophysical properties, especially in binding affinity, cell penetration, serum stability. To date, our study first one showcase that...
Intra-articular calcaneal fracture remains challenging to manage. Computed tomography and mapping are useful for the diagnosis treatment of fractures. The aim present study was characterize patterns using mapping.Sixty-two fractures were retrospectively included in study. For each case, simulated reduction manually. lines zones comminution graphically superimposed onto an intact template identify patterns. Major assessed by focusing on posterior joint facet, medial wall, lateral...
Accumulation and activation of immunocytes in adipose tissues are essential to obesity-induced inflammation insulin resistance. Chemokines pivotal for the recruitment tissue during obesity. Chemokine (C-C motif) ligand 5 (CCL5) plays a vital role sites inflammation. CCL5 expression level is increased obese from humans mice. However, remains unclear. Our study found that was epididymal white (eWAT) mice, particularly CD8 + T cells. knockout (KO) mice exhibited better glucose tolerance than...
Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer (CRC). Cisplatin-resistant cells exhibit an inherent ability to evade toxic chemotherapeutic drug effects which are characterized by activation slow-cycle programs DNA repair. Among elements that lead cisplatin resistance, O6-methylguanine (O6-MG)-DNA-methyltransferase (MGMT), DNA-repair enzyme, performs quintessential role. In this study, we clarify significant...