A5066596633- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Ischemic Stroke Management
- Anesthesia and Pain Management
- Meningioma and schwannoma management
- Treatment of Major Depression
- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Stroke Rehabilitation and Recovery
- Intraoperative Neuromonitoring and Anesthetic Effects
- COVID-19 and healthcare impacts
- Cerebrovascular and Carotid Artery Diseases
- Long-Term Effects of COVID-19
- Cancer, Stress, Anesthesia, and Immune Response
- Pituitary Gland Disorders and Treatments
- Nausea and vomiting management
- Pregnancy and preeclampsia studies
- Neurological Complications and Syndromes
- Spaceflight effects on biology
- Blood transfusion and management
- Pain Management and Opioid Use
Beijing Tian Tan Hospital
2014-2024
Capital Medical University
2014-2024
Outcomes Research Consortium
2023-2024
Southern Medical University
2024
Cleveland Clinic
2024
Beijing Tongren Hospital
2023
Society for Neuroscience
2020
Ministry of Science and Technology of the People's Republic of China
2020
Beijing Municipal Administration of Hospitals
2020
SUNY Downstate Health Sciences University
2015
No definitive conclusion can be made on the best choice of anesthesia for people with acute posterior circulation stroke during endovascular treatment. Only a few observational studies have focused this topic in recent years, and they differing conclusions. To examine whether conscious sedation (CS) is feasible alternative to general (GA) treatment patients stroke. A randomized parallel-group exploratory trial blinded end point evaluation (Choice Anesthesia Endovascular Treatment Acute...
The effect of choice anesthesia on clinical outcome for endovascular treatment (EVT) in patients with acute ischemic stroke (AIS) remains unclear.We conducted a pilot trial 43 anterior circulation having EVT. Patients were randomly allocated to receive general or conscious sedation. We documented the rate recruitment and conversion from sedation anesthesia. In addition, we recorded change National Institute Health scale (NIHSS) day 7, successful reperfusion measured neurological function by...
Background: Intravenous and inhalational anesthesia might have different associations with long-term outcome in cancer patients, reports of adverse effects inhalation anesthesia. However, the patients high-grade glioma (HGG) are not known. Methods: This study investigated 154 who received propofol 140 sevoflurane for maintenance during HGG tumor resection. The primary outcomes were progression-free survival overall survival. Results: Median was 10 months (interquartile range [IQR], 6 to 18)...
Perioperative lidocaine infusion has been reported to reduce postoperative pain in patients after abdominal surgery; however, no study examined lidocaine's effect on acute supratentorial tumor surgery.A total of 94 scheduled for craniotomy were enrolled. Patients received either through an intravenous bolus (1.5 mg/kg) induction followed by at a rate 2 mg/kg/h until the end surgery or same volume normal saline. Mean arterial blood pressure, heart rate, and bispectral index recorded different...
We hypothesized that the addition of dexmedetomidine in a clinically relevant dose to propofol-remifentanil anesthesia regimen does not exert an adverse effect on motor-evoked potentials (MEP) and somatosensory-evoked (SSEP) adult patients undergoing thoracic spinal cord tumor resection. Seventy-one were randomized into three groups. Propofol group (n = 25): regimenand dosage was adjusted maintain bispectral index (BIS) between 40 50. DP 23): Dexmedetomidine (0.5 μg/kg loading infused over...
BACKGROUND: Depressive symptoms occur in over 40% of neurosurgical patients during the perioperative period. However, no measure has been suggested to have a rapid effect on depressive surgical increasingly shorter stays hospital. This study aimed determine whether ketamine could improve rapidly and safely hospital stay. METHODS: was randomized, placebo-controlled, double-blinded trial. Patients with moderate-to-severe undergoing elective supratentorial brain tumor resection were randomized...
Gabapentin is an adjuvant antiepileptic agent and helps to reduce acute postoperative pain in several surgery settings. However, the effect of gabapentin on from suboccipital or subtemporal craniotomy not clear.The study was a single-center, randomized, placebo-controlled, double-blinded trial. A total 122 patients undergoing elective by approach were randomly allocated placebo group group. The received (600 mg, orally) night before 2 hours anesthesia induction group, vitamin B primary...
Background: Perioperative strokes may promote postoperative neurocognitive dysfunction. We thus evaluated the incidence of and association between outcomes in older patients recovering from non-cardiac surgery. Methods: PRECISION was a two-center prospective cohort study. aged ≥60 years who had elective, inpatient surgery at two Chinese academic centers. Postoperative were by scheduled magnetic resonance brain imaging within 7 days. Our primary outcome cumulative stroke. Secondary included...
The association between anesthesia type and outcomes in patients with acute ischemic stroke undergoing endovascular treatment (EVT) remains a subject of ongoing debate.This prospective nonrandomized controlled trial included 149 consecutive anterior circulation who underwent EVT. primary outcome was functional independence assessed by the modified Rankin Scale (mRS) after 3 months.A total 105 (70.5%) 44 (29.5%) EVT received conscious sedation (CS) general (GA), respectively. GA had similar...
Patients with malignant brain tumors frequently exhibit hypercoagulation and are at a high risk of postoperative thrombosis-related complications. However, the factors for complications remain unclear.In this retrospective, observational study, we consecutively enrolled elective patients undergoing resection from 26 November 2018 to 30 September 2021. The primary objective study was identify composite three major adverse events including lower limb deep venous thrombosis, pulmonary embolism,...
: There is equivocal evidence examining cognitive improvement in response to lidocaine during cardiac surgery; however, no study has examined its effect on postoperative neuropsychological-cognitive decline after supratentorial tumor surgery.Ninety-four patients scheduled for craniotomy were enrolled. Patients received either a dose of (2%) via an intravenous bolus (1.5 mg/kg) induction followed by infusion at rate 2 mg/kg/h until the end surgery (Lidocaine group) or same volume normal...
Background Observational studies indicate that the type of anesthesia, local or general, may be associated with post-procedural neurological function in patients acute ischemic stroke undergoing endovascular treatment. However, these results need further confirmation, and causal relationship has not yet been established. Methods This is a randomized controlled equivalence trial. Permuted block randomization stratified by culprit vessels will used. Six hundred forty recanalization one to...
Background: Previous studies report that intraoperative hypotension worsens outcomes after aneurysmal subarachnoid hemorrhage (aSAH). However, the hypotensive harm threshold for major adverse cardiovascular events (MACE) remains unclear. Methods: The authors included aSAH patients who had general anesthesia clipping/coiling. MACE were defined by a composite of acute myocardial injury, infarction, and other complications identified electrocardiogram echocardiography. initially used logistic...
The risk of brain swelling after dural opening is high in patients with midline shift undergoing supratentorial tumor surgery. Brain may result increased intracranial pressure, impeded exposure, and adverse outcomes. Mannitol recommended as a first-line dehydration treatment to reduce edema enable relaxation during neurosurgery. Research has indicated that mannitol enhanced surgery; however, these results need further confirmation, the optimal dose not yet been established. We propose...
Background: Mannitol is widely used to reduce brain tissue swelling and improve relaxation during neurosurgery. However, the optimal dosage for patients with midline shift undergoing supratentorial tumor resection remains unclear. Methods: In this randomized, controlled double-blinded study, 204 preoperative who underwent elective surgery were equally allocated receive placebo or 0.7, 1.0, 1.4 g/kg mannitol infusion. The primary outcome was proportion of satisfactory relaxation. Results:...
Background: Ketamine, a commonly used nonbarbiturate anesthetic drug, possesses antidepressant properties at subanesthetic doses; however, the underlying mechanisms remain unclear. Materials and Methods: The analgesic effects of ketamine were explored using complete Freund adjuvant (CFA)-induced peripheral inflammatory pain model in vivo. Mice first divided into sham or CFA injection group randomly, observed for mechanical hyperalgesia, depression-like behavior, mRNA expression caveolin-1 ....
Delayed cerebral ischemia (DCI) is the major predictor of poor outcomes in patients with aSAH. Previous studies have attempted to assess relationship between controlling blood pressure and DCI. However, management intraoperative reducing occurrence DCI still remains inconclusive.All aSAH who received general anesthesia for surgical clipping January 2015 December 2020 were prospectively reviewed. Patients divided group or non-DCI depending on whether occurred not. Intraoperative arterial was...
BACKGROUND: Dexmedetomidine was reported to reduce postoperative acute pain after neurosurgery. However, the efficacy of dexmedetomidine for preventing chronic incisional is uncertain. METHODS: This article a secondary analysis randomized, double-blind, placebo-controlled trial. Eligible patients were randomly allocated either group or placebo group. Patients assigned given 0.6 μg kg −1 bolus followed by 0.4 h maintenance dose until dural closure; comparable amounts normal saline. The...
Ventilator-induced lung injury is a major cause of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgery after general anesthesia. However, there no study on the effect lung-protective ventilation strategy neurosurgery. This single-center, randomized, parallel-group controlled trial which will be carried out at Beijing Tiantan Hospital, Capital Medical University. Three hundred and thirty-four intracranial tumor surgery randomly allocated to control group...
Introduction Postoperative delirium (POD) is a common complication. The incidence of POD about 25% in non-cardiac surgery and ranges from 10% to 30% neurological procedures. A lot trials show that dexmedetomidine might help reduce the patients undergoing surgery. However, impact on for craniotomy tumour resections remains unclear. Methods analysis study prospective, single-centre, randomised, double-blinded, paralleled-group controlled trial. Patients elective frontotemporal will be randomly...
Postoperative delirium (POD) is a common complication, and it has high incidence in neurosurgery patients. Awake craniotomy (AC) been widely performed patients with glioma eloquent motor areas. Most of the surgical procedure frontotemporal craniotomy, operation duration getting longer. Patients undergoing AC are high-risk populations for POD. Dexmedetomidine (Dex) administration perioperatively might help to reduce The purpose this study investigate effect Dex on POD AC.The prospective,...