A5102777000- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Airway Management and Intubation Techniques
- Barrier Structure and Function Studies
- Pediatric health and respiratory diseases
- Traditional Chinese Medicine Analysis
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Treatment of Major Depression
- Autism Spectrum Disorder Research
- Frailty in Older Adults
- Hemodynamic Monitoring and Therapy
- Cognitive and developmental aspects of mathematical skills
- Nutrition and Health in Aging
- Traditional Chinese Medicine Studies
- Neuroscience and Neuropharmacology Research
- Fuel Cells and Related Materials
- Neural dynamics and brain function
- Ultrasound in Clinical Applications
Chinese PLA General Hospital
2016-2025
People's Liberation Army No. 150 Hospital
2024
Chinese People's Liberation Army
2024
University of Electronic Science and Technology of China
2023-2024
University of Virginia
2021
Taihe Hospital
2013
It is widely accepted that mitochondria have a direct impact on neuronal function and survival. Oxidative stress caused by mitochondrial abnormalities play an important role in the pathophysiology of lipopolysaccharide (LPS)-induced memory impairment. Elamipretide (SS-31) novel mitochondrion-targeted antioxidant. However, elamipretide cognitive sequelae inflammatory oxidative unknown.We utilized MWM contextual fear conditioning test to assess hippocampus-related learning performance....
Considerable evidence has shown that neuroinflammation and oxidative stress play an important role in the pathophysiology of postoperative cognitive dysfunction (POCD) other progressive neurodegenerative disorders. Increasing suggests acetaminophen (APAP) unappreciated antioxidant anti-inflammatory properties. However, impact APAP on sequelae inflammatory is unknown. The objective this study to explore whether could have neuroprotective effects lipopolysaccharide (LPS)-induced impairment...
Little evidence on the association between geriatric nutritional risk index (GNRI) with prognosis and postoperative complications was observed. This study examined potential prognostic value of GNRI in elderly patients undergoing non-cardiac surgery. retrospective analysis data retried from Chinese patients' perioperative database (CEPPD), a multicenter registry, June 1st, 2012 to August 15th, 2019. Patients were categorized into at-risk group (GNRI ≤ 98) no-risk > 98). Kaplan–Meier...
The 18 kDa translocator protein (TSPO) is involved in the immune/inflammatory response. However, exact role that TSPO plays neuroinflammation-induced cognitive impairment still elusive. purpose of our present study was to investigate effects lentiviral-mediated hippocampal overexpression a mouse model LPS-induced impairment. We established using systematic daily administration lipopolysaccharide (LPS) (0.5 mg/kg). Microinjection dentate gyrus with lentiviral vectors, which contained cDNA...
Background: Perioperative strokes may promote postoperative neurocognitive dysfunction. We thus evaluated the incidence of and association between outcomes in older patients recovering from non-cardiac surgery. Methods: PRECISION was a two-center prospective cohort study. aged ≥60 years who had elective, inpatient surgery at two Chinese academic centers. Postoperative were by scheduled magnetic resonance brain imaging within 7 days. Our primary outcome cumulative stroke. Secondary included...
H19, a long noncoding RNA (lncRNA), reportedly protects myocardial cells (H9c2 cell line) against hypoxia-reoxygenation- (H/R-) induced injury. Dexmedetomidine (Dex) has an important protective effect, although its function and mechanism in cardiac ischemia/reperfusion (I/R) injury, especially for senile patients, requires further study. N6-methyladenosine (m 6 A) is the most abundant endogenous modification. However, effect of Dex postconditioning on m A modification rarely been reported....
<title>Abstract</title> Objective The ideal intraoperative inspired oxygen concentration remains controversial. We aimed to investigate the association between level of fraction (FiO<sub>2</sub>) and incidence postoperative pulmonary complications (PPCs) in patients undergoing non-cardiac surgery. Methods This was a retrospective cohort study elderly with surgery April 2020 January 2022. According FiO<sub>2</sub>, were divided into low (≤ 60%) high (> FiO<sub>2</sub> groups. primary...
Objective The ideal intra-operative inspired oxygen concentration remains controversial. We aimed to investigate the association between intraoperative fraction of (FiO 2 ) and incidence postoperative pulmonary complications (PPCs) in patients undergoing non-cardiothoracic surgery. Methods This was a retrospective cohort study elderly who underwent surgery April 2020 January 2022. According FiO , were divided into low (≤60%) high (&gt;60%) groups. primary outcome composite within first...
Whereas autism spectrum condition is known for its social and communicative challenges, some autistic children demonstrate unusual islets of abilities including those related to mathematics, the neurobiological underpinnings which are increasingly becoming focus research. Here we describe an 8-year-old boy with intellectual language yet exceptional arithmetic ability. He can perform verbal-based multiplication three- even four-digit numbers within 20 seconds. To gain insights into neural...
The effect of sulodexide (SLX) on obstructive jaundice- (OJ-) induced acute lung injury (ALI) in rats was examined this study.In study, 48 were randomly assigned to one six groups: sham, OJ, OJ+saline, OJ+SLX (0.5 mg/ml/d), (1 and (2 mg/ml/d). pathological assessed by histological analysis grading. ELISA kits used evaluate the expression IL-6, IL-1, TNF-α, syndecan-1 (SDC-1) bronchoalveolar lavage fluids (BALFs). Commercial assay performed malondialdehyde (MDA) production catalase (CAT)...
Objective To investigate the Du moxibustion therapy in treatment of chronic obstructive pulmonary disease (Chronic disease,COPD)at stable phase.Methods 60 cases lung COPD patients stage who received from January to December 2010 Taihe Hospital Traditional Chinese Medicine outpatient were randomly divided into two groups in,according case tail number,with 30 each.The control group was taken oral doxofylline tablets,0.2 g/time,2 time/d and ambroxol hydrochloride,30 mg/time,3 time/d.The treated...
Autism spectrum disorder (ASD) is a common neurodevelopmental condition. However, the dynamic temporal stability of functional connectivity (FC) in resting state networks remains unclear. In this study, we investigated using standard deviations Clustering Coefficients (CC) and Characteristic Path Length (CPL). Subsequently, examined correlation between age. Our analysis revealed significant differences values both CC CPL individuals with ASD healthy control (HC) group. Moreover, notable...
Objective To evaluate the efficacy of sevoflurane in preventing depression-like behavior mice and relationship with brain-derived neurotrophic factor(BDNF)/tyrosine kinase B(TrkB)signaling pathway. Methods Forty-four clean-grade male C57BL/6 mice, weighing 18-22 g, aged 8-10 weeks, were divided into 2 groups(n=22 each)using a random number table method: control group(group C)and S). Mice group C inhaled oxygen for 30 min, S 2.5% min.The forced swimming test novelty-suppressed feeding...