A5100391773- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroscience and Neuropharmacology Research
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Nosocomial Infections in ICU
- Sleep and Wakefulness Research
- Neurological Disease Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Trauma and Emergency Care Studies
- Sepsis Diagnosis and Treatment
- Plant-based Medicinal Research
- Angiogenesis and VEGF in Cancer
- Eosinophilic Disorders and Syndromes
- Intracranial Aneurysms: Treatment and Complications
- Renal Diseases and Glomerulopathies
- Thermal Regulation in Medicine
- Sleep and related disorders
- Optical Imaging and Spectroscopy Techniques
- Antibiotic Use and Resistance
- Infrared Thermography in Medicine
- Pneumocystis jirovecii pneumonia detection and treatment
Shanghai Chest Hospital
2021-2024
Shanghai Jiao Tong University
2021-2024
Zigong First People's Hospital
2024
Zhongnan Hospital of Wuhan University
2023
Wuhan University
2023
Shanxi Medical University
2023
Second Hospital of Shanxi Medical University
2023
Wenzhou Medical University
2023
Zhejiang Taizhou Hospital
2023
Tianjin Institute of Metrological Supervision Testing
2022
Considerable evidence has shown that neuroinflammation and oxidative stress play an important role in the pathophysiology of postoperative cognitive dysfunction (POCD) other progressive neurodegenerative disorders. Increasing suggests acetaminophen (APAP) unappreciated antioxidant anti-inflammatory properties. However, impact APAP on sequelae inflammatory is unknown. The objective this study to explore whether could have neuroprotective effects lipopolysaccharide (LPS)-induced impairment...
Summary The development of thrombosis in polycythaemia vera (PV) involves multifactorial processes including pathological activation blood cells. Release microparticles (MPs) by activated cells diseases is associated with thrombotic risk, but relatively few data are available PV. aim the present study was to investigate increase MP release and exposure phosphatidylserine (PS) on outer membrane MP-origin patients PV, analyse their procoagulant activity (PCA). PS-positive MPs were detected...
In patients who are successfully resuscitated after initial cardiac arrest (CA), mortality and morbidity rates high, due to ischemia/reperfusion injury the whole body including nervous immune systems. How interactions between these two critical systems contribute post-CA outcome remains largely unknown. Using a mouse model of CA cardiopulmonary resuscitation (CA/CPR), we demonstrate that CA/CPR induced neuroinflammation in brain, particular, marked increase pro-inflammatory cytokines, which...
Nosocomial infection (NI) is associated with poor prognosis. The present study assessed the clinical and microbiological characteristics of NI patients in intensive care unit (ICU) investigated impact risk factors for ICU patients. An observational was conducted an adult general ICU. electronic medical records all admitted to >2 days from 2018-2020 were analyzed retrospectively. Multivariate regression models used analyze Propensity score-matching (PSM) control confounding between case...
Background Recent research has revealed the potential value of machine learning (ML) models in improving prognostic prediction for patients with trauma. ML can enhance predictions and identify which factors contribute most to posttraumatic mortality. However, no studies have explored risk factors, complications, preoperative postoperative traumatic coagulopathy (PPTIC) Objective This study aims help clinicians implement timely appropriate interventions reduce incidence PPTIC related thereby...
The 18 kDa translocator protein (TSPO) is involved in the immune/inflammatory response. However, exact role that TSPO plays neuroinflammation-induced cognitive impairment still elusive. purpose of our present study was to investigate effects lentiviral-mediated hippocampal overexpression a mouse model LPS-induced impairment. We established using systematic daily administration lipopolysaccharide (LPS) (0.5 mg/kg). Microinjection dentate gyrus with lentiviral vectors, which contained cDNA...
Background: Immunosuppression caused by immune cell apoptosis and an imbalance of T helper 2 cells (T H 2) 1 1), is associated with poor outcomes in septic patients. Esmolol was reported to improve survival modulating responses shock. Whether esmolol could alleviate sepsis-induced immunosuppression the optimal dose are unclear. Methods: Four hours after cecal ligation puncture (CLP), Wistar rats were randomized into CLP, CLP + E-5 (esmolol: 5 mg·kg -1 ·h ) E-18 18 groups. Eight underwent...
The translocator protein (18 kDa) (TSPO) recently attracted increasing attention in the pathogenesis of post-traumatic stress disorder (PTSD). This study is testing hypothesis that overexpression TSPO hippocampus dentate gyrus (DG) could alleviate anxiogenic-like response mice model PTSD induced by foot-shock. In this study, hippocampal DG significantly reversed increase contextual freezing response, decrease percentage both entries into and time spent open arms elevated plus maze test...
In this study, we tested the hypothesis that Piezo1/Ca2+/calpain pathway of basal forebrain (BF) modulates impaired fear conditioning caused by sleep deprivation. Adult male Wistar rats were subjected to 6 h total deprivation using gentle handling protocol. Step-down inhibitory avoidance tests revealed induced substantial short- and long-term memory impairment in rats, which was accompanied increased Piezo1 protein expression (P < 0.01) cleavage full-length tropomyocin receptor kinase B...
Evidence suggests the involvement of N‑methyl‑D‑ aspartate receptors (NMDAR) in regulation neurogenesis. Functional properties NMDAR are strongly influenced by type NR2 subunits receptor complex. NR2A‑ and NR2B‑containing expressed neonatal forebrain regions, such as subventricular zone (SVZ). The aim present study was to examine effect protein expression hypoxic‑ischemic injury 2A 2B SVZ rats. Expression these other proteins interest performed using immunohistochemistry. results showed that...
Sciatica has been widely studied, but the association of sciatica with immune infiltration not studied. We aimed to screen key genes and further investigate impact in patients sciatica. The bioinformatics analyzes were performed based on GSE150408 dataset. Subsequently, we used CIBERSORT study disease group. Results showed that 13 differentially expressions group compared healthy participants, including 8 up-regulated 5 down-regulated genes. Through LASSO model SVM-RFE analysis, a total 6...
Background: Elderly patients with preexisting cognitive impairment are susceptible to postoperative dysfunction (POCD). In this study, we investigated whether there is local homogeneity and functional connectivity alteration in the brain before surgery for POCD as compared that non-POCD patients. Methods: Eighty elderly undergoing major thoracic or abdominal surgeries were recruited. Resting-state MRI was scanned at least 1 day surgery. Neuropsychological tests (NPTs) performed discharge,...
Objective: Pneumonia in ICU patients is a common and serious infection, cephalosporin antibiotics are widely used its treatment.However, there lack of systematic comprehensive evaluation on the efficacy safety patient pneumonia.This study aims to evaluate incidence adverse events pneumonia through meta-analysis.Methods: English databases (PubMed, Embase, Cochrane Library, Web Science) were searched from establishment each database until August 27, 2023. Randomized controlled trials (RCTs)...
<sec> <title>BACKGROUND</title> Recent research has revealed the potential value of machine learning (ML) models in improving prognostic prediction for patients with trauma. ML can enhance predictions and identify which factors contribute most to posttraumatic mortality. However, no studies have explored risk factors, complications, preoperative postoperative traumatic coagulopathy (PPTIC) </sec> <title>OBJECTIVE</title> This study aims help clinicians implement timely appropriate...
Clinical data of patients underwent pancreaticoduodenectomy due to malignant ampullary tumors from January 2013 and December 2016 in our hospital with full access medical records were collected, 144 enrolled total.Surgical Apgar Score (SAS) was calculated based on the intraoperative lowest mean arterial pressure, heart rate blood loss.The divided into 2 groups depending whether postoperative delirium developed or not within 7 days after surgery.The receiver operating characteristic curve SAS...
Nightmares are prevalent in psychiatric disorders, and personality disorder features might be associated with nightmare experience, especially patients. The authors invited 219 healthy volunteers 118 patients to undergo tests of the Nightmare Experience Questionnaire (NEQ), Parker Personality Measure (PERM), Plutchik-van Praag Depression Inventory. Compared volunteers, scored significantly higher on annual frequency NEQ Physical Effect, Negative Emotion, Meaning Interpretation, Horrible...
e20613 Background: Lung cancer is the leading mortality worldwide. Radiotherapy(RT) plays an important role in lung treatment. Different does fractionation of RT has different effects on prognosis cancer. For example, stereotactic body radiotherapy can significantly improve compared with conventionally Fractionated Radiotherapy. In non-small cell cancer, we have previously shown that Indoleamine 2,3-dioxygenase 1 (IDO1) metabolites and radiation induced changes had significant long-term...