A5100734326- Platelet Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Phagocytosis and Immune Regulation
- CAR-T cell therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Renal Diseases and Glomerulopathies
- Hematopoietic Stem Cell Transplantation
- Retinoids in leukemia and cellular processes
- Traditional Chinese Medicine Analysis
- Chronic Myeloid Leukemia Treatments
- Immune cells in cancer
- Hematological disorders and diagnostics
- Pregnancy and preeclampsia studies
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
- Blood properties and coagulation
- T-cell and B-cell Immunology
- Inflammatory Biomarkers in Disease Prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Immunotherapy and Immune Responses
- Kruppel-like factors research
Chinese Nutrition Society
2024
Weifang Medical University
2024
Xiamen University
2024
Sichuan Cancer Hospital
2017-2023
University of Electronic Science and Technology of China
2023
Southern University of Science and Technology
2021
Harbin Medical University
2011-2020
First Affiliated Hospital of Harbin Medical University
2011-2020
First Affiliated Hospital of Kunming Medical University
2017
Kunming Medical University
2017
Despite the presence of neutrophil extracellular traps [NETs] in inflamed colon having been confirmed, role NETs, especially circulating progression and thrombotic tendency inflammatory bowel disease [IBD] remains elusive. We extended our previous study to prove that NETs constitute a central component prothrombotic state IBD.In all 48 consecutive patients with IBD were studied. Acute colitis was induced by treatment C57BL/6 mice 3.5% dextran sulphate sodium [DSS] drinking water for 6 days....
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated disease of the peripheral nervous system. Th17 and Th1 cells contribute to pathogenesis most autoimmune diseases, but little known about their distribution reciprocal relationship in CIDP. In this study, we analyzed Th17, Th1, Th17/Th1 blood cerebrospinal fluid (CSF). The results showed that frequency was significantly higher mononuclear cell (PBMCs) CSF active CIDP comparison with remitting or other...
Summary The development of thrombosis in polycythaemia vera (PV) involves multifactorial processes including pathological activation blood cells. Release microparticles (MPs) by activated cells diseases is associated with thrombotic risk, but relatively few data are available PV. aim the present study was to investigate increase MP release and exposure phosphatidylserine (PS) on outer membrane MP-origin patients PV, analyse their procoagulant activity (PCA). PS-positive MPs were detected...
Abstract The mechanisms that eliminate activated platelets in inflammation-induced disseminated intravascular coagulation (DIC) micro-capillary circulation are poorly understood. This study explored an alternate pathway for platelet disposal mediated by endothelial cells (ECs) through phosphatidylserine (PS) and examined the effect of clearance on procoagulant activity (PCA) sepsis. Platelets septic patients demonstrated increased levels surface activation markers apoptotic vesicle...
Background/Aims: Pulmonary arterial endothelial plexiform lesions are a basic pathological change associated with pulmonary vascular remodeling and characterized by the formation of tumorlets as result over-growth cells. Accumulating evidence suggests that platelet-derived growth factor (PDGF) participates in regulating progression hypertension. However, whether PDGF promotes survival cells (PAECs), well specific molecular mechanisms underlie its actions, remains unknown. Methods: MTT...
The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health problem and novel therapeutic strategies are required to prevent treat T2DM. It has been demonstrated that resveratrol (RSV) may T2DM by targeting Sirtuin 1 (SIRT1), indicating SIRT1 be target for prevention. In the present study, rat model was established administering high fat diet streptozotocin (STZ) injections. Measurements blood glucose insulin confirmed successful establishment model. RSV used rats with...
Background: Gastrointestinal (gi) symptoms are the most notable side effects of chemotherapeutic drugs; such currently treated with drugs. In present study, we investigated effect acupuncture on gi induced by chemotherapy in patients advanced gastric cancer. Methods: A cohort 56 was randomly divided into an experimental group and a control group. All received combination oxaliplatin–paclitaxel. Patients 30 minutes therapy daily for 2 weeks. The frequency duration nausea, vomiting, abdominal...
The procoagulant status of patients with non-small cell lung cancer (NSCLC) after chemotherapy is poorly characterized and the role platelets in hypercoagulative state NSCLC unknown. aim this study was to evaluate activity (PCA) before chemotherapy. subjects were 52 newly diagnosed NSCLC. had decreased clotting time compared healthy subjects, thrombin-antithrombin complex increased 2.5-fold Platelets enhanced phosphatidylserine (PS) exposure, shortened coagulation as well thrombin fibrin...
Previous studies have highlighted that the transforming growth factor‑β1 (TGF‑β1) pathway may be activated by hypoxic conditions. TGF‑β1 also participates in regulation of proliferation, differentiation, migration and apoptosis various cell types. Furthermore, has been reported to participate progression pulmonary arterial hypertension (PAH). However, effect on smooth muscle cells (PASMCs) corresponding molecular mechanisms remain unclear. The present study aimed determine whether protects...
Abstract This study aimed to evaluate treatment response, survival, safety profiles, and predictive factors chimeric antigen receptor T cell (CAR-T) therapy in Chinese patients with relapsed or refractory B acute lymphoblast leukemia (R/R B-ALL). 39R/R B-ALL who underwent CAR-T were included. Baseline data collected from patients’ electronic medical records. Patients’ peripheral bloods, bone marrow aspirates, biopsies obtained for routine examination, response survival profiles as well...
Renovascular hypertension (RVHT) is characterized by renal artery stenosis and overactivated renin-angiotensin system (RAS). Apelin, known for its negative modulation of RAS, has protective effects against cardiovascular diseases. The role mechanisms the primary active form apelin, apelin-13, in RVHT are unclear. In this study, male Sprague-Dawley rats were divided into control, two-kidney one-clip (2K1C) model, 2K1C with apelin-13 treatment groups. Renin expression was analyzed using...
The mechanism of thrombogenicity in cirrhosis is largely unknown. Our objective was to study the relationship between phosphatidylserine on blood cells and endothelial hypercoagulable state cirrhotic patients.Patients with healthy controls were studied. Lactadherin used quantify exposure cells. Procoagulant activity evaluated using clotting time purified coagulation complex assays. Fibrin production determined by turbidity. Phosphatidylserine exposure, fibrin strands FVa/Xa binding observed...
Multiple myeloma (MM) is characterized by an increased incidence of thromboembolic events, particularly when treated with immunomodulatory drugs (IMiDs) in combination dexamethasone. The optimal prophylactic strategy to prevent the hypercoagulable state patients MM still debated. aim current study was investigate definitive role phosphatidylserine (PS) supporting procoagulant activity (PCA) MM. Patients (n=20) and healthy subjects (n=15) were recruited for present study. PS analyses...
Summary Amniotic fluid (AF) may induce disseminated intravascular coagulation (DIC) when it enters maternal circulation by breaching the placental-maternal barrier. The precise mechanism of procoagulant activity AF is unclear, but tissue factor (TF) has been proposed to be main cause. As one constituent AF, cells accumulate and undergo apoptosis continuously. Therefore, we speculate that have due externalisation phosphatidylserine (PS). present study aims demonstrate that, in addition TF, PS...