A5033925838- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phagocytosis and Immune Regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Extracellular vesicles in disease
- Immune cells in cancer
- Venous Thromboembolism Diagnosis and Management
- Blood properties and coagulation
- RNA modifications and cancer
- Inflammation biomarkers and pathways
- COVID-19 Clinical Research Studies
- Kruppel-like factors research
- Aortic Disease and Treatment Approaches
- Nitric Oxide and Endothelin Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Hepatitis B Virus Studies
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Flavonoids in Medical Research
- Blood groups and transfusion
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- Eosinophilic Disorders and Syndromes
- Cancer-related molecular mechanisms research
Qingdao University
2020-2024
Qingdao Municipal Hospital
2020-2024
Harbin Medical University
2016-2019
First Affiliated Hospital of Harbin Medical University
2016-2019
Oral squamous cell carcinoma (OSCC), the subtype of head and neck cancers, is notorious for its high incidence death rate. The role long non-coding RNAs (lncRNAs) discovered to be significant canceration cancer progression. Long intergenic non-protein coding RNA 958 (LINC00958) as a carcinogene in multiple such gastric cancer, pancreatic glioma, but there has been no report about how LINC00958 functions OSCC. objective our study unfold function mechanism investigation on First, TCGA database...
Background: Thromboembolism is the second leading cause of death among patients with non-small cell lung cancer (NSCLC), but precise mechanisms thrombogenesis in NSCLC remain largely unknown. Our objectives were to evaluate definitive role neutrophil extracellular traps (NETs) hypercoagulability and explore its interactions platelets endothelial cells (ECs). Methods: The levels NET markers samples from 100 30 healthy controls was measured by ELISA. formation detected using...
BACKGROUND: Patients with severe aortic stenosis, undergoing transcatheter valve replacement (TAVR), are more likely to develop thrombotic complications. However, the definite mechanisms underlying hypercoagulation state remain unclear date. Our objectives were explore whether and how neutrophil extracellular traps (NETs) play a procoagulant role in patients after TAVR alone or percutaneous coronary intervention within 1 year further evaluate their interactions platelets endothelial cells....
Multiple myeloma (MM) is characterized by an increased incidence of thromboembolic events, particularly when treated with immunomodulatory drugs (IMiDs) in combination dexamethasone. The optimal prophylactic strategy to prevent the hypercoagulable state patients MM still debated. aim current study was investigate definitive role phosphatidylserine (PS) supporting procoagulant activity (PCA) MM. Patients (n=20) and healthy subjects (n=15) were recruited for present study. PS analyses...
Interaction between the programmed cell death ligand 1 (PD-L1) and (PD-1) contributes to tumor resistance chemotherapeutic agents. PD-L1 is expressed in cells of diffuse large B-cell lymphoma (DLBCL), one common type malignant non-Hodgkin lymphomas. However, little known about how PD-1/PD-L1 pathway functions pathogenesis DLBCL. Therefore, present study investigated whether axis involved regulating sensitivity CRL2631, a DLBCL line, CHOP (Cyclophosphamide, Hydroxydaunorubicin/adriamycin,...
OBJECTIVE Phosphatidylserine (PS) is a major component of the inner leaflet membrane bilayers. During cell activation or apoptosis, PS externalized to outer membrane, providing an important physiological signal necessary for release microparticles (MPs) that are generated through budding cellular membranes. MPs express and antigens reflect their origin. exposure on surface provide binding sites factor Xa prothrombinase complexes promote thrombin formation. Relatively little known about role...
Essential hypertension (EH) patients suffer from paradoxically thrombotic rather than haemorrhagic, although the exact mechanism remains elusive. Our aim is to explore whether and how neutrophil extracellular traps (NETs) play procoagulant role in EH patients, as well evaluated NET releasing were triggered by inflammatory cytokines.The concentration of plasma NETs components detected ELISA. The morphology cells formation analysed using immunofluorescence. Procoagulant activity was clotting...
Abstract Background The mechanism of thrombotic complications in patients with aortic stenosis (AS) is unknown. Our aim was to evaluate the levels phosphodiesterase (PS) blood cells, endothelial cells (ECs), and extracellular vesicles (EVs) its procoagulant activity (PCA) different degrees AS. Methods Exposed PS ECs EVs were analyzed by flow cytometry. PCA evaluated clotting time (CT), intrinsic factor Xa (FXa), extrinsic FXa, thrombin fibrin formation assays. We also inhibitory effects...