A5031231828- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- Heavy metals in environment
- Ferroptosis and cancer prognosis
- Liver Diseases and Immunity
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Microplastics and Plastic Pollution
- Soil Carbon and Nitrogen Dynamics
- Lung Cancer Research Studies
- Recycling and Waste Management Techniques
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Microbial Community Ecology and Physiology
- RNA Research and Splicing
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Mycorrhizal Fungi and Plant Interactions
- Hepatocellular Carcinoma Treatment and Prognosis
- Bladder and Urothelial Cancer Treatments
- Geochemistry and Geologic Mapping
- Pancreatic and Hepatic Oncology Research
Zhejiang Chinese Medical University
2025
Hangzhou First People's Hospital
2025
Changzhou University
2025
Guangdong University of Technology
2025
Shanghai Jiao Tong University
2015-2024
Beijing Institute of Water
2024
Beijing Anzhen Hospital
2008-2024
Capital Medical University
2008-2024
Renji Hospital
2018-2024
Nanjing Drum Tower Hospital
2017-2024
Lung cancer (LC) is one of the most serious malignant tumors, which has fastest growing morbidity and mortality worldwide. A role lung microbiota in LC pathogenesis been analyzed, but a comparable gut not yet investigated. In this study, 30 patients healthy controls were examined via next-generation sequencing 16S rRNA analyzed for diversity biomarkers. We found that there was no decrease significant microbial (alpha diversity) compared to (P observed = 0.1422), while composition (beta...
It was first observed that PPL, lipase from porcine pancreas, and several other lipases have a promiscuous ability to catalyse asymmetric aldol reactions between acetones aldehydes in the presence of water.
The natural polyphenolic compound curcumin has been proved to modulate innate immune responses and possess anti-inflammatory properties. Nevertheless, the mechanism remains poorly understood, particularly regarding curcumin-regulated miRNAs under inflammatory response.This study investigates role of miRNA-155 in effects on response cell a mouse model.The activity (5, 10 15 μM, 2 h) lipopolysaccharide (LPS, 200 ng/mL)-induced cells were measured by quantitative PCR. animals treated orally 20...
Stratification of cancer patients into distinct molecular subgroups based on multi-omics data is an important issue in the context precision medicine. Here, we present MOVICS, R package for integration and visualization subtyping. MOVICS provides a unified interface 10 state-of-the-art integrative clustering algorithms, incorporates most commonly used downstream analyses subtyping researches, including characterization comparison identified subtypes from multiple perspectives, verification...
The Corona Virus Disease 2019 (COVID-19) pandemic has attracted increasing worldwide attention. While metabolic-associated fatty liver disease (MAFLD) affects a quarter of world population, its impact on COVID-19 severity not been characterized. We identified 55 MAFLD patients with COVID-19, who were 1:1 matched by age, sex and obesity status to non-aged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected without MAFLD. Our results demonstrate that in aged less than 60...
Ovarian cancer is the third most common in female reproductive organs and epithelial ovarian has highest lethality of all gynecological cancers. Pomegranate fruit juice (PFJ) been shown to inhibit growth several types other than cancer. In this study, we exposed cell line A2780 PFJ two its components (ellagic acid luteolin). MTT wound healing assays demonstrated that three treatments suppressed proliferation migration cells. addition, western blotting ELISA showed expression levels MMP2 MMP9...
Regarding rubber tree plantations, researchers lack a basic understanding of soil microbial communities; specifically, little is known about whether or not variation correlated with succession in these plantations. In this paper, we used high-throughput sequencing the 16S rRNA gene to investigate diversity and composition bacterial communities chronosequence plantations that were 5, 10, 13, 18, 25 30 years old. We determined that: (1) Soil show changes over stages The bacteria highest 13 18...
The heterogeneity of the immune microenvironment leads to different responses in checkpoint blockade therapy. We aimed propose a robust molecular classification system investigate relevance subtype and prognosis prostate cancer patients, as well therapeutic response A total 1,557 patients were enrolled, including 69 real‐world samples from our institute (titled AHMU‐PC cohort). non‐negative matrix factorization algorithm was employed virtually microdissect patients. enrichment characterized...
Immunotherapy is a potential way to save the lives of patients with bladder cancer, but it only benefits approximately 20% them. A total 4,028 cancer were collected for this study. Unsupervised non-negative matrix factorization and nearest template prediction algorithms employed classification. We identified immune non-immune classes from The Cancer Genome Atlas Bladder Urothelial Carcinoma (TCGA-BLCA) training cohort. 150 most differentially expressed genes between these two extracted,...
The triglyceride-glucose (TyG) index, which is a reliable substitute indicator for insulin resistance, has been considered an independent risk factor long-term outcomes in patients with cardiovascular disease. However, it remains unknown whether the TyG index associated poor prognosis acute coronary syndrome (ACS) prior artery bypass grafting (CABG) undergoing percutaneous intervention (PCI).A total of 1158 ACS CABG PCI were retrospectively studied. was calculated by ln[fasting triglyceride...
Cancer stem cells (CSCs) are the most intractable subpopulation of triple-negative breast cancer (TNBC) cells, which have been associated with a high risk relapse and poor prognosis. However, eradication CSCs continues to be difficult. Here, we integrate multiomics data TNBC cohort (n = 360) identify vital markers CSCs. We discover that EMSY, inducing BRCAness phenotype, is preferentially expressed in CSCs, promotes ALDH+ enrichment, positively correlated relapse-free survival....