A5005278584- Advanced Memory and Neural Computing
- Ferroptosis and cancer prognosis
- Ferroelectric and Negative Capacitance Devices
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Urinary Bladder and Prostate Research
- Epigenetics and DNA Methylation
- Photoreceptor and optogenetics research
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Semiconductor materials and devices
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Renal and related cancers
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Mercury impact and mitigation studies
- Neural Networks and Reservoir Computing
- RNA Research and Splicing
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Neuroscience and Neural Engineering
- Bioinformatics and Genomic Networks
Shandong University
2025
Shanghai Innovative Research Center of Traditional Chinese Medicine
2021-2025
University of Rochester Medical Center
2018-2025
Anhui Medical University
2017-2024
First Affiliated Hospital of Anhui Medical University
2017-2024
Shanghai Fudan Microelectronics (China)
2020-2024
Fudan University
2020-2024
Guizhou Provincial People's Hospital
2024
Anhui Provincial Hospital
2024
State Key Laboratory of ASIC and System
2020-2023
With the development and application of artificial intelligence, there is an appeal to exploitation various sensors memories. As most important perception human beings, vision occupies more than 80% all received information. Inspired by biological eyes, retina based on 2D Janus MoSSe was fabricated, which could simulate functions visual with electronic/ion optical comodulation. Furthermore, inspired brain, sensing, memory, neuromorphic computing were integrated one device for multifunctional...
Neuromorphic computing memristors are attractive to construct low-power- consumption electronic textiles due the intrinsic interwoven architecture and promising applications in wearable electronics. Developing reconfigurable fiber-based is an efficient method realize that capable of neuromorphic function. However, previously reported artificial synapse neuron need different materials configurations, making it difficult multiple functions a single device. Herein, textile memristor network Ag/MoS
Abstract With the development of wearable devices and hafnium-based ferroelectrics (FE), there is an increasing demand for high-performance flexible ferroelectric memories. However, developing memories that simultaneously exhibit good flexibility significant performance has proven challenging. Here, we developed a field-effect transistor (FeFET) device with thermal budget less than 400 °C by integrating Zr-doped HfO 2 (HZO) ultra-thin indium tin oxide (ITO). The proposed FeFET large memory...
Although the energy consumption of reported neuromorphic computing devices inspired by biological systems has become lower than traditional memory, it still remains greater bio-synapses (≈10 fJ per spike). Herein, a flexible MoS2-based heterosynapse is designed with two modulation modes, an electronic mode and photoexcited mode. A one-step mechanical exfoliation method on substrate low-temperature atomic layer deposition process compatible electronics are developed for fabricating wearable...
Stratification of cancer patients into distinct molecular subgroups based on multi-omics data is an important issue in the context precision medicine. Here, we present MOVICS, R package for integration and visualization subtyping. MOVICS provides a unified interface 10 state-of-the-art integrative clustering algorithms, incorporates most commonly used downstream analyses subtyping researches, including characterization comparison identified subtypes from multiple perspectives, verification...
Abstract The demand of flexible neuromorphic computing electronics is increasing with the rapid development wearable artificial intelligent devices. resistive random‐access memory (RRAM) one excellent candidate high‐density storage However, due to limitations fabrication process, materials system and device structure, it difficult prepare 3D network for computing. In this paper, a memristors developed via low‐temperature atomic layer deposition (ALD) at 130°C, potential extending various...
The heterogeneity of the immune microenvironment leads to different responses in checkpoint blockade therapy. We aimed propose a robust molecular classification system investigate relevance subtype and prognosis prostate cancer patients, as well therapeutic response A total 1,557 patients were enrolled, including 69 real‐world samples from our institute (titled AHMU‐PC cohort). non‐negative matrix factorization algorithm was employed virtually microdissect patients. enrichment characterized...
The antiandrogen enzalutamide (Enz) has improved survival in castration resistant prostate cancer (CRPC) patients. However, most patients eventually develop Enz resistance that may involve inducing the androgen receptor (AR) splicing variant 7 (ARv7). Here we report high expression of monoamine oxidase-A (MAO-A) is associated with positive ARv7 detection CRPC following treatment. Targeting MAO-A phenelzine or clorgyline, FDA-approved drugs for antidepression, resensitize (EnzR) cells to...
Immunotherapy is a potential way to save the lives of patients with bladder cancer, but it only benefits approximately 20% them. A total 4,028 cancer were collected for this study. Unsupervised non-negative matrix factorization and nearest template prediction algorithms employed classification. We identified immune non-immune classes from The Cancer Genome Atlas Bladder Urothelial Carcinoma (TCGA-BLCA) training cohort. 150 most differentially expressed genes between these two extracted,...
Abstract While the androgen receptor (AR) may influence progression of clear cell renal carcinoma (ccRCC), its role to impact vasculogenic mimicry (VM) alter ccRCC and metastasis remains obscure. Here, we demonstrated that elevated AR expression was positively correlated with tumor-originated vasculogenesis in patients. Consistently, vitro research revealed promoted VM formation lines via modulating lncRNA-TANAR/TWIST1 signals. Mechanism dissection showed could increase lncRNA-TANAR (TANAR)...
Abstract Although androgen receptor (AR) can influence bladder cancer (BCa) initiation and progression, its impact on tumor immune escape remains unclear. Here, we found that targeting AR could enhance natural killer (NK) cell tumor-killing efficacy by decreasing PD-L1 expression. Both antiandrogen treatment knockdown effectively reduced membrane PD-LI expression to facilitate NK cell-mediated BCa killing downregulating circ_0001005. Mechanistically, upregulated circRNA circ_0001005 via the...
With the development of bioelectronics, brain-inspired artificial synapses become more and important. To simulate synapse, a HfAlO ferroelectric tunnel junction (FTJ) was fabricated, which can short-term synaptic plasticity for neuromorphic computing. The devices realize function with low power consumption about 7.15 aJ per event. Moreover, to explore effect oxygen defects on properties HfAlO-based device, first-principle analysis further carried out. These results pave way hafnium-based devices.
Abstract Clear cell renal carcinoma (ccRCC) is a heterogeneous tumor with different genetic and molecular alterations. Schemes for ccRCC classification system based on multiomics are urgent, to promote further biological insights. Two hundred fifty‐five patients paired data of clinical information, transcriptome expression profiles, copy number alterations, DNA methylation, somatic mutations were collected identification. Bioinformatic analyses performed our team's recently developed R...
Hafnium oxide (HfO2)-based ferroelectric tunnel junctions (FTJs) have been extensively evaluated for high-speed and low-power memory applications. Herein, we investigated the influence of Al content in HfAlO thin films on characteristics HfAlO-based FTJs. Among devices with different Hf/Al ratios (20:1, 34:1, 50:1), device ratio 34:1 exhibited highest remanent polarization excellent and, thereby, best ferroelectricity among devices. Furthermore, first-principal analyses verified that...
Abstract Accumulating evidence shows HOOK1 disordered in human malignancies. However, the clinicopathological and biological significance of renal cell carcinoma (RCC) remains rarely studied. In this study, authors demonstrate that is downregulated RCC samples with predicted poorer clinical prognosis. Mechanistically, inhibits tumor growth metastasis via canonical TGF‐ β /ALK5/p‐Smad3 non‐canonical /MEK/ERK/c‐Myc pathway. At same time, angiogenesis sunitinib resistance by promoting...
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent disease of the urogenital system. Alcohol has been reported to be closely related CP/CPPS. Thus, we intended verify role alcohol in CP/CPPS and determine underlying mechanism.We induced experimental autoimmune prostatitis (EAP) mouse model by intradermally injecting mixture prostate antigens (PAgs) complete Freund's adjuvant on days 0 28. Mice were treated with (control-alcohol EAP-alcohol groups) or vehicle...
Pyroptosis is essential for tumorigenesis and progression of neoplasm. However, the heterogeneity pyroptosis its relationship with tumor microenvironment (TME) in clear cell renal carcinoma (ccRCC) remain unclear. The purpose present study was to identify pyroptosis-related subtypes construct a prognosis prediction model based on signatures.First, heterogenous subgroups were explored 33 genes ccRCC samples from TCGA, established by LASSO regression verified ICGC database. Then, clinical...
Abstract Traditional von Neumann architecture is facing severe challenges due to separated physical structure of memory and processing units, which inspires the development in‐memory computing electronics. Intriguingly, as a kind complementary metal‐oxide‐semiconducor compatible ferroelectric material, HfO 2 widely studied based on first‐principles calculation in semiconductor field, showing great potential constructing emerging Different structures including diode, field effect transistor,...
Information-processing devices are the core components of modern electronics. Integrating them into textiles is indispensable demand for electronic to form close-loop functional systems. Memristors with crossbar configuration regarded as promising building blocks design woven information-processing that seamlessly unify textiles. However, memristors always suffer from severe temporal and spatial variations due random growth conductive filaments during filamentary switching processes. Here,...
Abstract Photoelectric synaptic devices could emulate behaviors utilizing photoelectric effects and offer promising prospects with their high-speed operation low crosstalk. In this study, we introduced a novel InGaZnO-based memristor. Under both electrical optical stimulation, the device successfully emulated characteristics including excitatory postsynaptic current (EPSC), paired-pulse facilitation (PPF), long-term potentiation (LTP), depression (LTD). Furthermore, demonstrated practical...