A5040974046- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Melanoma and MAPK Pathways
- Renal and related cancers
- Microtubule and mitosis dynamics
- Peptidase Inhibition and Analysis
- Antifungal resistance and susceptibility
- Epigenetics and DNA Methylation
- Synthesis and Biological Evaluation
- Protein Degradation and Inhibitors
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- RNA Research and Splicing
- TGF-β signaling in diseases
- Renal cell carcinoma treatment
- Synthesis and biological activity
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Quinazolinone synthesis and applications
Hangzhou Medical College
2025
Cardiovascular Institute of the South
2025
University of Rochester Medical Center
2015-2024
Guangdong Ocean University
2024
Shenyang Pharmaceutical University
2019-2024
Shandong Academy of Forestry
2022-2024
Research Institute of Forestry
2024
Chinese Academy of Forestry
2024
University of South China
2024
Shaanxi University of Science and Technology
2023
Abstract While the antiandrogen enzalutamide (Enz) extends castration resistant prostate cancer (CRPC) patients’ survival an extra 4.8 months, it might also result in some adverse effects via inducing neuroendocrine differentiation (NED). Here we found that lncRNA-p21 is highly expressed NEPC patients derived xenograft tissues (NEPC-PDX). Results from cell lines and human clinical sample surveys revealed expression up-regulated Enz treatment could increase to induce NED. Mechanism dissection...
Drosophila Mad proteins are intracellular signal transducers of decapentaplegic (dpp), the transforming growth factor β (TGF-β)/bone morphogenic protein (BMP) homolog. Studies in which mammalian Smad homologs were transiently overexpressed cultured cells have implicated Smad2 TGF-β signaling, but physiological relevance Smad3 signaling by receptors has not been established. Here we stably expressed at controlled levels epithelial using a novel approach that combines highly efficient...
Transforming growth factor beta (TGF-beta) regulates a variety of physiologic processes, including inhibition, differentiation, and induction apoptosis. Some TGF-beta-initiated signals are conveyed through Smad3; TGF-beta binding to its receptors induces phosphorylation Smad3, which then migrates the nucleus where it functions as transcription factor. We describe here association Smad3 with nuclear protooncogene protein SnoN. Overexpression SnoN represses transcriptional activation by Smad3....
While the androgen receptor (AR) might promote renal cell carcinoma (RCC) initiation and progression, molecular mechanisms involved remain largely unclear. Here, we discovered novel LncRNA-SARCC, which was suppressed associated with better prognosis in RCC. Preclinical studies using multiple RCC cells vivo mouse model indicated that LncRNA-SARCC could attenuate invasion, migration proliferation vitro vivo. Mechanistically, bound destabilized AR protein an inhibition of function, led to...
Hepatocellular carcinoma (HCC) is a heterogeneous malignancy as result of complex genetic and epigenetic alterations. HCC characterized by clear gender disparity for which there lack mechanistic understanding. Androgen receptor (AR) thought to be critical such bias. Meanwhile, the potential function circular RNA (circRNA), regulated editing enzyme, remained largely unknown in till now. By utilizing circRNA microarray survey coupled with vitro analysis, we analyzed influence AR on expression...
Abstract Androgen-deprivation therapy (ADT) with newly developed antiandrogen enzalutamide (Enz) may increase the castration-resistant prostate cancer (CRPC) patients survival an extra 4.8 months. Yet eventually most fail development of Enz resistance. While recent clinical studies indicated that increased expression androgen receptor (AR) splicing variant ARv7 might have key roles for resistance in CRPC, its detailed mechanism, especially linkage to circular RNAs (circRNAs), a form...
Small cell neuroendocrine carcinoma (SCNC) of the prostate is a variant form cancer that occurs de novo or as recurrent tumor in patients who received hormonal therapy for prostatic adenocarcinoma. It composed pure (NE) cells, but unlike scattered NE cells benign and adenocarcinoma are quiescent, SCNC highly proliferative aggressive, causing death months. In this study, we provide evidence interleukin 8 (IL8)–CXCR2–P53 (TP53) signaling pathway keeps quiescent state normally. While P53...
Clear cell renal carcinoma (ccRCC) is a gender-biased tumor. Here we report that there also gender difference between pulmonary metastasis and lymph node showing the androgen receptor (AR)-positive ccRCC may prefer to metastasize lung rather than nodes. A higher AR expression increases hematogenous yet decreases lymphatic metastases. Mechanism dissection indicates enhances miR-185-5p via binding response elements located on promoter of miR-185-5p, which suppresses VEGF-C its 3' UTR. In...
It is well established that hypoxia contributes to tumor progression in a inducible factor-2α (HIF-2α)-dependent manner renal cell carcinoma (RCC), yet the role of long noncoding RNAs (LncRNAs) involved hypoxia-mediated RCC remains unclear. Here we demonstrate LncRNA-SARCC (Suppressing Androgen Receptor Renal Cell Carcinoma) differentially regulated by von Hippel-Lindau (VHL)-dependent both culture and clinical specimens. can suppress hypoxic cycle VHL-mutant cells while derepress it...
Abstract Early studies have indicated that estrogen receptor beta (ERβ) can influence the progression of clear cell renal carcinoma (ccRCC). Here, we report mechanistic details ERβ-mediated ccRCC. ERβ increased ccRCC invasion via suppression circular RNA ATP2B1 (circATP2B1) expression by binding directly to 5′ promoter region its host gene ATPase plasma membrane Ca2+ transporting 1 (ATP2B1). ERβ-suppressed circATP2B1 then led reduced miR-204-3p, which fibronectin (FN1) and enhanced invasion....
The androgen receptor (AR) was found to suppress hepatocellular carcinoma (HCC) metastasis at late stages. Due this discovery, we searched for some AR enhancers increase the efficacy of Sorafenib chemotherapy, and identified microRNA (miR)-367-3p, whose expression is positively correlated with in advanced HCC, as an HCC suppressor. Combining miR-367-3p showed better cell invasion vitro vivo. Mechanism dissection revealed that could via directly targeting 3′UTR MDM2 decrease protein...
Prostatic small cell neuroendocrine carcinoma (SCNC) is a rare but aggressive form of prostate cancer that negative for androgen receptor (AR) and not responsive to hormonal therapy. The molecular etiology this variant well understood; however, mutation the p53 (TP53) tumor suppressor in cells inactivates IL8-CXCR2-p53 pathway normally inhibits cellular proliferation, leading development SCNC. SCNC also overexpresses Aurora kinase A (AURKA) which considered be viable therapeutic target....
Abstract While the androgen receptor (AR) may influence progression of clear cell renal carcinoma (ccRCC), its role to impact vasculogenic mimicry (VM) alter ccRCC and metastasis remains obscure. Here, we demonstrated that elevated AR expression was positively correlated with tumor-originated vasculogenesis in patients. Consistently, vitro research revealed promoted VM formation lines via modulating lncRNA-TANAR/TWIST1 signals. Mechanism dissection showed could increase lncRNA-TANAR (TANAR)...
The bark of Eucommia ulmoides (a perennial deciduous tree termed eucommia hereafter) has anti-hyperlipidemia effects due to its bioactive components. However, the slow growth leads a deficit in this resource. Studies have shown that leaf components similar those and effects. At present, strength effect not been reported. Their interaction with gut microbiota mechanism by which exerts are unclear.Through fecal transplantation (FMT) experiments, study aimed investigate bacteria suspensions...
Acute pancreatitis (AP) is a common abdominal disease that typically resolves on its own, but the mortality rate dramatically increases when it progresses to severe acute (SAP).In this study, we investigated molecular mechanism underlying development of SAP from AP.We utilized two models induced by pancreatic duct ligation and caerulein administration.Transcriptomic proteomic analyses were subsequently performed determine mRNA protein expression profiles samples AP model normal mice.To...
Although sorafenib is currently used as a standard treatment for advanced hepatocellular carcinoma, low response rate, transient and limited efficacy, primary acquired resistance negative side-effects gain increasing attentions, suggesting the need better efficacious combination therapy. Here, we demonstrated that sorafenib-induced or hypoxia-induced hypoxia inducible factor (HIF)-2α could bind to an responsive element within 500 bp region of androgen receptor (AR) promoter thus...