A5003903359- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemicals and Antioxidant Activities
- Synthesis of Organic Compounds
- Gut microbiota and health
- Fungal Biology and Applications
- Pharmacological Effects of Natural Compounds
- Biochemical Analysis and Sensing Techniques
- Polysaccharides and Plant Cell Walls
- Heavy Metal Exposure and Toxicity
- Sesquiterpenes and Asteraceae Studies
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Chromatography in Natural Products
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Tea Polyphenols and Effects
- Synthesis and Catalytic Reactions
- Phytochemistry and Bioactive Compounds
- COVID-19 Clinical Research Studies
- Food Quality and Safety Studies
- Phytochemistry and Biological Activities
- Morinda citrifolia extract uses
- SARS-CoV-2 and COVID-19 Research
Shaanxi University of Science and Technology
2021-2024
University of North Carolina at Chapel Hill
2020-2024
Shanghai University of Traditional Chinese Medicine
2024
Yanshan University
2024
Office of Infectious Diseases
2023
Johns Hopkins University Center for AIDS Research
2023
XinHua Hospital
2022
Jilin Agricultural University
2021
University of Chinese Academy of Sciences
2013-2020
Shanghai Institute of Nutrition and Health
2020
<h3>Objective</h3> Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited effective treatment options. An alternative strategy to target cells, such as tumour-infiltrating macrophages, in the HCC tumour microenvironment. The CCL2/CCR2 axis required for recruitment of monocytes/macrophages and implicated various aspects liver pathology, including HCC. We investigated feasibility a therapeutic against <h3>Design</h3> CCL2 expression was analysed two independent cohorts. Growth...
Background There is an urgent need for effective treatments hepatocellular carcinoma (HCC). Immunotherapy promising especially when combined with traditional therapies. This study aimed to investigate the immunomodulatory function of approved Chinese medicine formula, compound kushen injection (CKI), and its anti-HCC efficiency in combination low-dose sorafenib. Methods Growth two murine HCC cells was evaluated orthotopic model, a subcutaneous postsurgical recurrence tumor rechallenge model...
In this study, the structure of Siraitia grosvenorii polysaccharides (SGPs) changed significantly after digestion. After 48 h in vitro fecal fermentation, Mw decreased and content CR showed a trend increasing then decreasing. The monosaccharide composition (glucose) SGPs decreasing stabilizing during indicating that were partially degraded fermentation utilized by human intestinal microbiota. addition, for increased production SCFAs especially acetic acid, propionic butyric acid. Moreover,...
The bark of Eucommia ulmoides (a perennial deciduous tree termed eucommia hereafter) has anti-hyperlipidemia effects due to its bioactive components. However, the slow growth leads a deficit in this resource. Studies have shown that leaf components similar those and effects. At present, strength effect not been reported. Their interaction with gut microbiota mechanism by which exerts are unclear.Through fecal transplantation (FMT) experiments, study aimed investigate bacteria suspensions...
Respiratory syncytial virus (RSV) infection causes significant morbidity and mortality in infants, immunocompromised individuals, older individuals. There is an urgent need for effective antivirals vaccines high-risk We used 2 complementary vivo models to analyze RSV-associated human lung pathology immune correlates of protection. RSV resulted widespread epithelial damage, a proinflammatory innate response, elicited natural adaptive response that conferred protective immunity. demonstrated...
From Siraitia grosvenorii, a natural polysaccharide named SGP-1 was discovered, and its purity determined to be 96.83%. Its structure is glucan with 4-, 6- 4,6-linked glucose units. In this paper, the sulfated derivative S-SGP of prepared by chlorosulfonic acid method. The derivatives were analyzed Fourier transform infrared spectroscopy (FT-IR), gel permeation chromatography (GPC), scanning electron microscopy (SEM). degree substitution (DS) 0.62, weight average molecular (Mw) 1.34 × 104...
Background: Cadmium (Cd) is an environmental contaminant that poses risks to human and animal health. Selenium (Se), a beneficial element, alleviates the detrimental consequences of colitis Cd toxicity. Se found in food products as both inorganic (sodium selenite) organic (typically Se-enriched yeast). Nano-selenium (nano-Se; novel form produced through bioreduction species) has recently garnered considerable interest, although its effects against Cd-induced enterotoxicity are poorly...
NF-κB, a transcriptional regulator of diverse genes involved in cell survival, proliferation, adhesion, and apoptosis, has been implicated various malignancies. We discovered potent natural NF-κB inhibitor, Japonicone A, from the traditional herb Inula japonica Thunb, evaluated its preclinical pharmacology therapeutic activity, investigated underlying mechanisms action for antitumor activity.Various types cancer normal cells were exposed to A cytotoxicity screening, followed by determination...
Abstract A diastereoselective and enantioselective formal [4+1] ylide annulation of chiral sulfonium salts with various substituted α‐substituted nitroalkene leading to optically active isoxazoline N ‐oxides using CF 3 SO − as a key anion has been explored. The salient features this methodology include high diastereo‐ enantioselecties, easily available starting materials, mild reaction conditions, simple procedure, broad substrate scope the are conveniently transformed into other...