A5114269537- Prostate Cancer Treatment and Research
- Random lasers and scattering media
- Renal cell carcinoma treatment
- Multiple and Secondary Primary Cancers
- Natural product bioactivities and synthesis
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Diabetes Management and Research
- Pancreatic function and diabetes
- Image and Video Quality Assessment
- Advanced Optical Imaging Technologies
- Optical Coherence Tomography Applications
- Ubiquitin and proteasome pathways
- Diabetes and associated disorders
- NF-κB Signaling Pathways
- Advanced Proteomics Techniques and Applications
- Testicular diseases and treatments
- Acupuncture Treatment Research Studies
- Therapeutic Uses of Natural Elements
- Neural Networks and Reservoir Computing
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Pluripotent Stem Cells Research
- Lignin and Wood Chemistry
- Granular flow and fluidized beds
Changhai Hospital
2013-2025
Second Military Medical University
2013-2025
Shanghai Cell Therapy Research Institute
2023
Southern Medical University
2022
State Key Laboratory of Remote Sensing Science
2020-2021
University of Chinese Academy of Sciences
2013-2020
Shanghai Institutes for Biological Sciences
2020
Shanghai Institute of Nutrition and Health
2020
University of Pennsylvania
2014
Cancer Research Institute
2014
The ability to interconvert terminally differentiated cells could serve as a powerful tool for cell-based treatment of degenerative diseases, including diabetes mellitus. To determine which, if any, adult tissues are competent activate an islet β cell program, we performed in vivo screen by expressing three "reprogramming factors" wide spectrum tissues. We report that transient intestinal expression these factors-Pdx1, MafA, and Ngn3 (PMN)-promotes rapid conversion crypt into endocrine...
Background There is an urgent need for effective treatments hepatocellular carcinoma (HCC). Immunotherapy promising especially when combined with traditional therapies. This study aimed to investigate the immunomodulatory function of approved Chinese medicine formula, compound kushen injection (CKI), and its anti-HCC efficiency in combination low-dose sorafenib. Methods Growth two murine HCC cells was evaluated orthotopic model, a subcutaneous postsurgical recurrence tumor rechallenge model...
Ghost imaging is widely used in underwater active optical because of its simple structure, long distance, and non-local imaging. However, the complexity environment will greatly reduce quality ghost To solve this problem, an method based on generative adversarial networks proposed study. The generator network adopts U-Net with double skip connections attention module to improve reconstruction quality. In training process, total loss function sum weighted loss, perceptual pixel loss....
Organ-on-a-chip culture systems using human organ tissues provide invaluable preclinical insights into systemic functions in vitro .
Abstract Renal cell carcinoma (RCC), a prevalent urinary system malignancy, often metastasizes at an early stage. Characterized by complex pathogenesis and high mortality rate, RCC poses significant clinical challenge. We evaluated the expression level of EMX2 in patients revealed reduction expression, correlating with poor patient prognosis. functions as tumor suppressor inhibits proliferation migration, accompanied programmed death. Implantation EMX2-transduced cells beneath mouse kidney...
Building upon our previous investigation of genomic, epigenomic, and transcriptomic profiles prostate cancer in China, we conducted a comprehensive analysis proteomic phosphoproteomic 82 tumor tissues matched adjacent normal from 41 Chinese patients with localized cancer. We identified three distinct subtypes significant difference both molecular features clinical prognosis. Notably, these exhibited parallel degree heterogeneity the phosphoproteome, featuring unique metabolism,...
Background Prostate cancer (PCa) is the most common malignant tumor of male urinary system. Cuproptosis, as a novel regulated cell death, remains unclear in PCa. This study aimed to investigate role cuproptosis-related genes (CRGs) molecular stratification, prognostic prediction, and clinical decision-making Methods Cuproptosis-related subtypes were identified by consensus clustering analysis. A signature was constructed with LASSO cox regression analyses 10-fold cross-validation. It further...
Rationale: Constitutive activation of the NF-κB signalling pathway plays a pivotal role in pathogenesis activated B cell-like diffuse large B-cell lymphomas (ABC-DLBCLs), most aggressive and chemoresistant form DLBCL. In ABC-DLBCLs, CARMA1-BCL10 (CB) complex forms filamentous structure functions as supramolecular organizing centre (CB-SMOC) that is required for constitutive activation, making it an attractive drug target ABC-DLBCL treatment. However, pharmaceutical approach targeting CB-SMOC...
Introduction The fertility of cryptorchidism patients who didn’t perform corrective surgery will decrease with age. Herein, we elucidate the histological alterations and underlying molecular mechanism in an increase disease duration from 20 to 40 years. Methods Testicular tissues were obtained three cryptorchidism, ranging age 22 44 Three benign paracancerous testicular samples matched ages used as controls. normal undescended stained hematoxylin eosin (HE) immunofluorescence all six...
Background: Chemotherapy-induced nausea and vomiting severely impairs the treatment prognosis of cancer patients. Depressive mood disorder might aggravate in patients; however, role neurotransmitters receptors involved mediation emesis is still not well elaborated. Methods: The study was carried out based on chronic unpredictable mild stress-induced depression-like phenotype rat model cisplatin-induced pica establishment. Forty male Sprague-Dawley rats were randomized into non-treated...
A modified Split-Bregman iteration method is proposed to reconstruct the image of target in computational ghost imaging. Different from conventional iteration, each reconstruction result denoised by BM3D filter proposed, which can help reduce noise final reconstructed effectively. The has high quality effectiveness and able retain edge texture detail information well. numerical simulation experiment results verify feasibility method. Comparing with other methods qualitatively quantitatively,...
Prostate cancer (PCa) is the most common malignant tumor in men. Currently, there are few prognosis indicators for predicting PCa outcomes and guiding treatments. Here, we perform comprehensive proteomic profiling of 918 tissue specimens from 306 Chinese patients with using data-independent acquisition mass spectrometry (DIA-MS). We identify over 10,000 proteins define three molecular subtypes significant clinical differences. develop a 16-protein panel that effectively predicts biochemical...
<title>Abstract</title> <bold>Objective</bold>: To investigate the potential association between body mass index (BMI) and clinicopathological features of patients with clear cell renal carcinoma (ccRCC). <bold>Methods</bold>: We retrospectively analyzed data from 2451 who underwent partial or radical nephrectomy for masses 2013 2023 in a single institution. Patients were divided into normal-weight, overweight, obese groups based on Chinese BMI classification. Clinicopathological features,...
We have evaluated whether targeting the Src family kinase cascade, an early component of B-cell receptor (BCR) signaling, is effective strategy to treat AIDS-related lymphoma (ARL). kinases are activated after ligation BCR and they phosphorylate downstream signaling proteins in tyrosine residues relaying cascades that lead B cell activation proliferation. These play important role pathogenesis. shown constitutively active diffuse large (DLBCL) cells occurring immunocompetent individuals...
The reconstruction quality of binary ghost imaging depends on the speckle binarization process. In order to obtain better and improve imaging, a local adaptive method based fuzzy integral is proposed in this study. There are three steps first step calculate image with summed-area table algorithm. Secondly, calculated through discrete Choquet integral. Finally, threshold each pixel selected result. experiment results verify feasibility method. Compared other methods qualitatively...