A5100425296- Stress Responses and Cortisol
- Hair Growth and Disorders
- Tryptophan and brain disorders
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Dermatologic Treatments and Research
- Neuroinflammation and Neurodegeneration Mechanisms
- melanin and skin pigmentation
- Skin Protection and Aging
- Heart Rate Variability and Autonomic Control
- Circadian rhythm and melatonin
- Mental Health Research Topics
- Urinary Bladder and Prostate Research
- Neuroendocrine regulation and behavior
- Sleep and related disorders
- Telomeres, Telomerase, and Senescence
- Animal Vocal Communication and Behavior
- Nanocomposite Films for Food Packaging
- Silk-based biomaterials and applications
- Immune Cell Function and Interaction
- Wnt/β-catenin signaling in development and cancer
- Apelin-related biomedical research
- Peroxisome Proliferator-Activated Receptors
- Human-Automation Interaction and Safety
University of Chinese Academy of Sciences
2014-2025
Shanghai Jiao Tong University
2015-2025
Northwest A&F University
2017-2025
Shanghai Institute of Nutrition and Health
2018-2025
Xuzhou Central Hospital
2025
Xuzhou Medical College
2017-2025
Shanghai Children's Hospital
2023-2025
University of Science and Technology of China
2025
Kunming Institute of Botany
2024
Chinese Academy of Sciences
2009-2024
Activating hair follicle stem cells (HFSCs) to promote regrowth holds promise for loss therapy, while challenges still remain develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe detachable microneedle patch-mediated drug delivery system, mainly made from hair-derived keratin, sustained of HFSC activators. It was demonstrated this device integrated with mesenchymal cell (MSC)-derived exosomes small molecular drug, UK5099, could enhance the...
Since inhaled glucocorticoids are the first-line treatment for asthma, asthma management becomes extremely difficult when does not react well to glucocorticoids. Formononetin, a bioactive isoflavone and typical phytoestrogen, has been shown have an anti-inflammatory impact while alleviating epithelial barrier dysfunction, which plays role in pathogenesis of allergic illnesses like asthma. However, biological mechanisms behind this unknown. As result, we set out investigate effects...
Antimicrobial packing showed great potential in extending the shelf life of food. However, developing a new biocomposite film with an intelligent and efficient antimicrobial performance is still desirable. Herein, Fe-MoOx encapsulated curcumin (Cur) filled chitosan-based composite (CCF films) was prepared by solvent casting method. The total color differences CCF films were less than 30%, satisfactory surface color, transparency, hydrophobicity, thermal stability also obtained. Besides,...
This study aimed to investigate the role of gut-lung microbiome axis in airway inflammation asthma and evaluate effect azithromycin on this axis, with a focus potential mechanism by which reduces allergic inflammation. Haematoxylin eosin (H&E) periodic acid-Schiff (PAS) staining were used assess pathological changes lung tissues asthmatic mice. Leukocyte cell types bronchoalveolar lavage fluid (BALF) samples quantified following Wright-Giemsa staining. Total IgE, OVA-specific IL-4, IL-6,...
Academic examination is a major stressor for students in China. Investigation of stress-sensitive endocrine responses to stress serves as good model naturalistic chronic psychological an otherwise healthy population. The cortisol awakening response (CAR) marker the hypothalamic-pituitary-adrenocortical (HPA) axis stress. However, it remains unknown how impacts CAR young population To exclude influence sex effects on hormone level, and were assessed two consecutive workdays 42 male...
Abstract Background Low-intensity pulsed ultrasound (LIPUS) has been reported to accelerate fracture healing, but the mechanism is unclear and its efficacy needs be further optimized. Ultrasound in combination with functionalized microbubbles shown induce local shear forces controllable mechanical stress cells, amplifying effects of LIPUS. Nanoscale lipid bubbles (nanobubbles) have high stability good biosafety. However, effect LIPUS combined nanobubbles on osteogenesis rarely studied....
Previously, we identified miR-125b as a key regulator of the undifferentiated state hair follicle stem cells. Here, show that in both mice and humans, is abundantly expressed, particularly at early stages malignant progression to squamous cell carcinoma (SCC), second most prevalent cancer worldwide. Moreover, when elevated normal murine epidermis, promotes tumor initiation contributes progression. We further can confer “oncomiR addiction” stage progenitors by delaying their differentiation...
Abstract Background Histone modifications play a critical role in chromatin remodelling and regulate gene expression health disease. methyltransferases EZH1, EZH2, demethylases UTX, JMJD3, UTY catalyse trimethylation of lysine 27 on histone H3 (H3K27me3). This study was designed to investigate whether H3K27me3 triggers hyperglycemia-induced oxidative inflammatory transcriptional programs the endothelium. Methods We studied human aortic endothelial cells exposed high glucose (HAEC) or...
Hair conditions, such as hair loss and graying, are prevalent human conditions. But they often poorly controlled due to our insufficient understanding of scalp follicle (hsHF) in health disease. Here we describe a comprehensive single-cell RNA-seq (scRNA-seq) analysis on highly purified black early-stage graying hsHFs. Based these, concise atlas for hsHF its early changes is generated verified using samples from multiple independent individuals. These data reveal the lineage trajectory...
Although microRNA (miRNA)-mediated functions have been implicated in many aspects of animal development, the majority miRNA::mRNA regulatory interactions remain to be characterized experimentally. We used an AIN/GW182 protein immunoprecipitation approach systematically analyze during C. elegans development. composition miRNAs functional miRNA-induced silencing complexes(miRISCs) at each developmental stage and identified three sets with distinct stage-specificity function. then thousands...
Heparan sulfate proteoglycans (HSPGs) are required for various signaling pathways, one of which is the bone morphogenetic protein (BMP) pathway. N-deacetylase/N-sulfotransferase-1 (NDST1) participates in synthesizing heparan (HS) chains HSPGs, and involved lung development. Here, we report that spite redundant expression Ndst2, Ndst3 Ndst4 genes, Ndst1(-/-) mice display defective differentiation cells increased cell proliferation. Loss Ndst1 enhances downstream BMP vivo. Noggin, an...
Data mining has been widely applied to make prediction for finance crisis risk, and they often obtain a good result. Financial distress can be formulated as classification problem using data mining. Many methods used solve the early-warning problem, however, "one time" process cannot well support decision, one single method its weakness classification. In this paper, we use information fusion technique build model based on methods, which integrate respective strengths from different improve...
Paraoxonase1 (PON1) activity is closely related to coronary artery disease (CAD). However, whether PON1 can predict the degree of stenosis remains unknown. In present study, serum and factors that influence were analyzed in 186 patients with diagnostic angiography. The was determined using a spectrophotometry-based assay angiography, which severity graded clinically defined as single- or multi-vessel >50%. Target lesion quantified via quantitative angiography (QCA). significantly decreased...
Abstract The present study investigated the effect of acute stress on attentional bias to threat using behavioral and ERP methods. Sixty-two male participants were randomly assigned a condition (Trier Social Stress Test) or control condition. To examine impact stress-induced cortisol threat, in group split into Low- High responders. All then administered modified dot probe task which cues neutral angry faces. Behavioral results showed pattern toward Control but not group. For ERPs, P100...
Aging of epidermal keratinocytes profoundly impacts skin health, contributing to changes in appearance, barrier function, and susceptibility diseases. Despite its significance, the molecular mechanisms underlying aging remain elusive. In this study, a reversible immortalized cell line was established by expressing SV40T using Tet-Off lentiviral system. Inducing senescent phenotype terminating expression revealed significant reduction mitotic ability, as well characteristics cellular aging....