A5052901133- Pediatric health and respiratory diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Asthma and respiratory diseases
- Winter Sports Injuries and Performance
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurosurgical Procedures and Complications
- Intensive Care Unit Cognitive Disorders
- Blood Pressure and Hypertension Studies
- Kruppel-like factors research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Healthcare Systems and Public Health
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- IL-33, ST2, and ILC Pathways
- Aquatic life and conservation
- Sports injuries and prevention
- Stress Responses and Cortisol
- Endoplasmic Reticulum Stress and Disease
- Psoriasis: Treatment and Pathogenesis
- Parkinson's Disease Mechanisms and Treatments
Wuxi Taihu Hospital
2023
Anhui Medical University
2021-2023
Beijing Sport University
2005-2022
Nanjing Medical University
2022
University of Calabria
2016
Sichuan University
2007
State Key Laboratory of Biotherapy
2007
Traumatic brain injury (TBI) is a major public health problem and cause of mortality disability that imposes substantial economic burden worldwide. Dexmedetomidine (DEX), highly selective α‑2‑adrenergic receptor agonist functions as sedative analgesic with minimal respiratory depression, has been reported to alleviate early (EBI) following traumatic by reducing reactive oxygen species (ROS) production, apoptosis autophagy. Autophagy programmed cell death mechanism serves vital role in...
Subarachnoid hemorrhage (SAH) is a life-threatening cerebrovascular disease, and most of the SAH patients experience sleep deprivation during their hospital stay. It well-known that one key components developing several neurological disorders, but its effect on brain damage after has not been determined. Therefore, this study was designed to evaluate using an experimental model in rats. Induction for 24 h aggravated SAH-induced damage, as evidenced by edema, neuronal apoptosis activation...
Spontaneous intracerebral hemorrhage (ICH) is a subtype of stroke associated with high mortality and morbidity due to the lack effective therapy. Obstructive sleep apnea (OSA) has been reported aggravate early brain injury (EBI) worsen overall outcome patients ICH. However, precise role OSA‑mediated neuroinflammation apoptosis following ICH not confirmed. The present study aimed investigate neuronal damage induced by OSA potential molecular mechanisms which ICH‑induced EBI regulates neural...
Spontaneous intracerebral hemorrhage (ICH) is a major public health problem with huge economic burden worldwide. Ulinastatin (UTI), serine protease inhibitor, has been reported to be anti-inflammatory, immune regulation, and organ protection by reducing reactive oxygen species production, inflammation. Necroptosis programmed cell death mechanism that plays vital role in neuronal after ICH. However, the neuroprotection of UTI ICH not confirmed, potential unclear. The present study aimed...
Background: Although the importance of physical fitness for injury prevention is recognized in sports medicine and rehabilitation, few studies have investigated this factor among recreational alpine skiers. Objective: To determine effect lower extremity on risk severity Method: This prospective cohort study involved 117 skiers at two resorts during 2021–2022 winter season. Anthropometric characteristics, skiing skills, agility (hexagon test), balance (Y-Balance Test), endurance (60-s squat...
Background: Postsynaptic density (PSD) is an electron-dense structure that contains various scaffolding and signaling proteins. Shank1 a master regulator of the synaptic scaffold located at glutamatergic synapses, has been proposed to be involved in multiple neurological disorders. Methods: In this study, we investigated role shank1 vitro Parkinson’s disease (PD) model mimicked by 6-OHDA treatment neuronal SN4741 cells. The expression related molecules was detected western blot...
Long non-coding RNA potassium voltage-gated channel subfamily Q member 1 opposite strand (lnc-KCNQ1OT1) represses inflammation and multiple organ dysfunction, whereas its clinical value in sepsis is unclear. Thus, this study aimed to explore issue.Lnc-KCNQ1OT1 from peripheral blood mononuclear cells were detected by RT-qPCR 116 patients 60 healthy controls (HCs). Moreover, followed-up until death or up 28 days.Lnc-KCNQ1OT1 decreased with than HCs (p < 0.001). In patients, lnc-KCNQ1OT1 was...
Objective: To investigate the role and mechanism of IL-17 CXCR4 in chronic graft nephropathy (CAN) rat models. Methods: CAN models were established using Fisher 344 to Lewis rats. In control group(n=10), rats performed isotransplantation. experimental group(n=10). All havested 6 weeks after transplantation. Kidneys examined by pathology evaluate injury renal allograft. SDF-1/CXCR4, α-SMA expression level serum detected immunohistochemical staining Enzyme-linked immunosorbent assays(ELISA)....
Abstract Spontaneous subarachnoid hemorrhage (SAH) is an acute neurologic emergency with poor outcomes, and mitochondrial dysfunction known as one of the key pathological mechanisms underlying SAH-induced early brain injury (EBI). 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate (T817MA) a newly synthesized neurotrophic compound that has been demonstrated to exert protective effects against injury. Here, we investigated effect T817MA in neuronal following experimental SAH...