A5069053017- RNA modifications and cancer
- Cancer-related gene regulation
- Connective Tissue Growth Factor Research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Wnt/β-catenin signaling in development and cancer
- Axon Guidance and Neuronal Signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- TGF-β signaling in diseases
- Circular RNAs in diseases
- RNA Research and Splicing
- MRI in cancer diagnosis
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Cancer, Lipids, and Metabolism
Changchun University of Chinese Medicine
2022-2025
Shanghai Pulmonary Hospital
2025
Tongji University
2025
Chinese Academy of Sciences
2013-2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Shanghai Institutes for Biological Sciences
2014-2024
Anhui University of Traditional Chinese Medicine
2024
Qingdao University
2016-2024
Affiliated Hospital of Qingdao University
2016-2024
Duke University
2024
Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for FcγRI, FcγRIIA, FcγRIIB, FcγRIIIA, and FcRn has been determined. common set residues is involved to all FcγR; FcγRII FcγRIII also utilize outside this set. In addition which, when altered, abrogated one or more receptors, several were found that improved only specific simultaneously type...
<h3>Objective</h3> Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited effective treatment options. An alternative strategy to target cells, such as tumour-infiltrating macrophages, in the HCC tumour microenvironment. The CCL2/CCR2 axis required for recruitment of monocytes/macrophages and implicated various aspects liver pathology, including HCC. We investigated feasibility a therapeutic against <h3>Design</h3> CCL2 expression was analysed two independent cohorts. Growth...
Abstract Iron homeostasis disturbance has been implicated in Alzheimer’s disease (AD), and excess iron exacerbates oxidative damage cognitive defects. Ferroptosis is a nonapoptotic form of cell death dependent upon intracellular iron. However, the involvement ferroptosis pathogenesis AD remains elusive. Here, we report that ferroportin1 (Fpn), only identified mammalian nonheme exporter, was downregulated brains APPswe/PS1dE9 mice as an mouse model patients. Genetic deletion Fpn principal...
Iron excess is closely associated with tumorigenesis in multiple types of human cancers, underlying mechanisms yet unclear. Recently, iron deprivation has emerged as a major strategy for chemotherapy, but it exerts tumor suppression only on select malignancies. Here, we report that the suppressor protein p53 downregulated during excess. Strikingly, polyporphyrin heme binds to protein, interferes p53-DNA interactions, and triggers both nuclear export cytosolic degradation p53. Moreover,...
Metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at distant site. The pathophysiological course of metastasis mediated the dynamic plasticity cancer cells, enables them to shift between epithelial mesenchymal phenotypes through transcriptionally regulated program termed epithelial-to-mesenchymal transition (EMT) its reverse process, mesenchymal-to-epithelial (MET). Using mouse model spontaneous metastatic breast cancer, we...
Abstract The growing knowledge of ferroptosis has suggested the role and therapeutic potential in cancer, but not been translated into effective therapy. Liver primarily hepatocellular carcinoma (HCC), is highly lethal with limited treatment options. LIFR frequently downregulated HCC. Here, by studying hepatocyte-specific inducible Lifr-knockout mice, we show that loss Lifr promotes liver tumorigenesis confers resistance to drug-induced ferroptosis. Mechanistically, activates NF-κB signaling...
Abstract The biological properties of CCN proteins include stimulation cell proliferation, migration, and adhesion, as well angiogenesis tumorigenesis. We quantified CYR61, CTGF, WISP-1, NOV mRNA expression levels in samples from sixty-six primary gliomas five normal brain using quantitative real-time PCR assay. Statistical analysis was performed to explore the links between genes clinical pathological parameters. Overexpression occurred 48% (32 66), 58% (38 36% (24 15% (10 66) gliomas,...
Environmental cadmium, with a high average dietary intake, is severe public health risk. However, the long-term implications of environmental exposure to cadmium in different life stages remain unclear.
RACK1 dictates the response of intracellular stress sensor IRE1α to different extracellular stimuli.
Gastric cardia cancer (GCC), which occurs at the gastric-esophageal boundary, is one of most malignant tumors. Despite its high mortality and morbidity, molecular mechanism initiation progression this disease largely unknown. In study, using proteomics metabolomics approaches, we found that level several enzymes their related metabolic intermediates involved in glucose metabolism were deregulated GCC. Among these enzymes, two subunits controlling pyruvic acid efflux, lactate dehydrogenase A...
Portal vein tumor thrombus (PVTT) is a significant poor prognostic factor for hepatocellular carcinoma (HCC). Patients with PVTT limited to first‐order branch of the main portal (MPV) or above could benefit from negative margin (R0) liver resection (LR). An Eastern Hepatobiliary Surgery Hospital (EHBH)/PVTT scoring system was established predict prognosis HCC patients after R0 LR and guide selection subgroups that LR. MPV who underwent as an initial therapy were included. The EHBH‐PVTT score...
Significance In this study, we find that ARID2 expression is negatively correlated with HCC metastasis and positively associated prognosis of patients. We demonstrate inhibits cells by recruiting DNMT1 to the promoter Snail, which elevates DNA methylation suppresses Snail transcription. Notably, discover a C2H2 truncated mutation (3817C > T) in metastatic tissue. further reveal domain required for ARID2–DNMT1 interaction loss-of-function mutants disrupted are poor survival Taken together,...
Abstract Cyr61 is a member of the CCN family growth factors; these proteins are secreted and can act as ligands distinct integrins. We show that enhance tumorigenicity glioma cells acting through activated integrin-linked kinase (ILK) to stimulate β-catenin-TCF/Lef Akt signaling pathways. Overexpression occurred in highly tumorigenic cell lines 68% most malignant glioblastoma multiforme brain tumors. Forced expression U343 accelerated their liquid culture, enhanced anchorage-independent...
To identify genes involved in breast cancer, polymerase chain reaction-selected cDNA subtraction was utilized to construct a cancer-subtracted library. Differential screening of the library isolated growth factor-inducible immediate-early geneCyr61, secreted, cysteine-rich, heparin binding protein that promotes endothelial cell adhesion, migration, and neovascularization. Northern analysis revealed Cyr61was expressed highly invasive cancer lines MDA-MB-231, T47D, MDA-MB-157; very low levels...
BackgroundCCN family, comprising six members (Cyr61, CTGF, Nov, WISP-1, WISP-2, WISP-3), is involved in the stimulation of cell proliferation, migration, adhesion, angiogenesis, and tumorigenesis. Several studies have shown that expression Cyr61, WISP-1 affects tumorigenic potential lung cancer cells vitro. However, correlation CCN family proteins clinical features remains unknown.Methodology Principal FindingsIn present work, we quantified mRNA levels samples from 60 primary cancers their...