A5063956745- Acute Ischemic Stroke Management
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Stroke Rehabilitation and Recovery
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Rheumatoid Arthritis Research and Therapies
- RNA modifications and cancer
- Immune Cell Function and Interaction
- S100 Proteins and Annexins
- Inflammatory Bowel Disease
- Bone Metabolism and Diseases
- Cancer Cells and Metastasis
- Sirtuins and Resveratrol in Medicine
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Osteoarthritis Treatment and Mechanisms
- RNA regulation and disease
- Ubiquitin and proteasome pathways
Huazhong University of Science and Technology
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Capital Institute of Pediatrics
2024
Fujian Medical University
2021-2024
Hainan General Hospital
2024
Xiangya Hospital Central South University
2012-2023
Jiaxing University
2017-2023
Affiliated Hospital of Hebei University
2023
Central South University
2012-2023
Guangzhou University of Chinese Medicine
2014-2023
The present study was designed to investigate the role of β-amyloid (Aβ1-42 ) in inducing neuronal pyroptosis and its mechanism. Mice cortical neurons (MCNs) were used this study, LPS + Nigericin induce MCNs (positive control group), Aβ1-42 interfere with MCNs. In addition, propidium iodide (PI) staining examine cell permeability, lactate dehydrogenase (LDH) release assay employed detect cytotoxicity, immunofluorescence (IF) expression level key protein GSDMD, Western blot performed levels...
Abstract Eph receptors, the largest subfamily of transmembrane tyrosine kinase have been increasingly implicated in various physiologic and pathologic processes, roles family members during tumorigenesis recently attracted growing attention. Until now, research on EphB3 function cancer is limited to focusing tumor suppression by EphB receptors colorectal cancer. However, its other types remains poorly investigated. In this study, we explored non–small-cell lung (NSCLC). We found that...
Accumulating evidence has suggested that cancer stem cells (CSCs) are at the root of drug resistance, and recent studies have indicated caveolin-1, a membrane transporter protein, is involved in regulation chemoresistance cell signaling. However, current understanding role caveolin-1 breast development remains controversial. Herein, we demonstrate expression was upregulated after chemotherapy vitro vivo, accompanied by co-overexpression β-catenin ATP-binding cassette subfamily G member 2...
Hair follicle stem cells (HFSCs) are maintained in a quiescent state until activated to grow, but the mechanisms that reactivate HFSC reservoir unclear. Here, we find loss of Sirt7 mice impedes hair life-cycle transition from telogen anagen phase, resulting delay growth. Conversely, overexpression during phase facilitated HSFC entry and accelerated Mechanistically, is upregulated HFSCs telogen-to-anagen transition, HFSC-specific knockout (Sirt7f/f ;K15-Cre) exhibit similar growth delay. At...
Abstract Background Study on the expression of miRNA‐22 in serum Alzheimer's disease (AD) patients and mechanism neuroinflammation regulation. Methods ELISA assay was used to detect level inflammatory factors, including interleukin‐1β (IL‐1β), interleukin‐18 (IL‐18), tumor necrosis factor‐α AD patients. TargetScan database luciferase reporter gene indicated that gasdermin D (GSDMD) target miRNA‐22. mimic transfected into microglia, followed by administration LPS Nigericin induce pyroptosis....
Abstract Objective This study was mainly conducted to explore the expression changes of GSDMD and conventional markers (including T‐Tau, Tau181p, Aβ 1–42 ) in cerebrospinal fluid among patients with Alzheimer's disease (AD) vascular dementia (VD), followed by determination role diagnosing identifying AD VD. Methods In this study, 60 VD, AD, 50 healthy controls were enrolled. Lumbar puncture performed collect samples. Patients VD evaluated using Mini‐Mental State Examination (MMSE) scale,...
Abstract M2 macrophages can promote liver cancer metastasis by promoting tumour angiogenesis; however, the mechanism underlying macrophage polarization has not been completely revealed. In this study, we mainly explored long non‐coding RNA‐CRNDE (lncRNA‐CRNDE) in regulating and angiogenesis. The expression of CRNDE was up‐regulated or down‐regulated THP‐1 cells (CRNDE ‐/‐ ‐THP‐1 pcDNA3.1‐CRNDE‐THP‐1). were co‐cultured with cell line H22, induced IL‐4/13 to simulate tumour‐induced...
Carbon ion therapy is a promising modality in radiotherapy to treat tumors, however, potential risk of induction late normal tissue damage should still be investigated and protected. The aim the present study was explore long-term cognitive deficits provoked by high-linear energy transfer (high-LET) carbon ions mice targeting hippocampus which plays crucial role memory learning. Our data showed that, one month after 4 Gy exposure, irradiation conspicuously resulted impaired performance,...
Abstract Objective To detect the expression of high‐mobility group box protein 1 (HMGB1) and toll‐like receptor 4 (TLR4) their downstream signaling factors—myeloid differentiation factor 88 (MyD88), nuclear kappa B (NF‐κB), tumor necrosis alpha (TNF‐α)—in sera patients with Parkinson's disease (PD) in order to evaluate relationship HMGB1–TLR4 axis PD development progression. Methods The serum HMGB1 TLR4 levels 120 100 healthy volunteers were measured using double‐antibody sandwich ELISA,...
Alternatively activated macrophages in tumor microenvironment is defined as M2 tumor-associated (M2 TAMs) that promote cancer progression. However, communicative mechanisms between TAMs and cells squamous cell carcinoma of head neck (SCCHN) remain largely unknown. Quantitative real-time PCR, western blotting, enzyme-linked immunosorbent assay flow cytometry were applied to quantify mRNA protein expression genes related TAMs, epithelial–mesenchymal transition (EMT) stemness. Wounding-healing...
Piperine (PIP), the main active ingredient in pepper, belongs to cinnamamide alkaloid. PIP has been found have functions, including anti-oxidation, immune regulation, anti-tumour and promotion of drug metabolism. The present study was mainly designed reveal effect against gastric cancer relevant mechanism. In brief, undifferentiated human cell HGC-27 used, which treated with different concentrations PIP. As a result, could inhibit proliferation induce apoptosis cells dose-dependent manner....
Background This study aims to systematically assess the risk factors, overall strength of association, and evidence quality related sepsis-associated encephalopathy. Methods A systematic search was conducted in Cochrane Library, PubMed, Web Science, Embase for cohort or case-control studies published up August 2023 on factors associated with sepsis-related The selected were screened, data extracted, evaluated using Newcastle–Ottawa Scale. Meta-analysis performed RevMan 5.3 software....
<title>Abstract</title> <bold>Background:</bold>Eosinophilic pleural fluid is a unique type of fluid, the causes which need to be further studied. In this study, number test indicators were collected understand characteristics eosinophilic effusion better analyze and provide useful information for clinical practice. <bold>Methods: </bold>A retrospective analysis was performed by examining medical records 2769 patients with (PE) from September 2013 January 2024. Blood routine, blood...
Eosinophilic pleural effusion constitutes a captivating and salient subject for exploration. In order to find out the reasons behind formation of eosinophilic effusion, we chose this study, hoping gradually unravel its mysterious veil. The absolute value percentage eosinophils in healthy people (normal control group), peripheral blood patients, patients were compared analyze their characteristics. with level was significantly greater than that group) (p < 0.0001) as well, even within...
Obesity is associated with numerous immunological disorders. The present study investigated the proportion and phenotype of myeloid‑derived suppressor cells (MDSCs) in plasma obese subjects association these level liver enzymes. Certain features immune response were examined by analyzing expression T cell receptor‑ζ (TCRζ) molecules on surface cells. secretion S100A9, a possible marker for MDSCs, detected peripheral blood compared levels lean controls. Results showed that percentage...
Background and Purpose— We aimed to develop a risk score (intracerebral hemorrhage–associated pneumonia score, ICH-APS) for predicting hospital-acquired stroke-associated (SAP) after ICH. Methods— The ICH-APS was developed based on the China National Stroke Registry (CNSR), in which eligible patients were randomly divided into derivation (60%) validation (40%) cohorts. Variables routinely collected at presentation used SAP For testing added value of hematoma volume measure, we separately 2...
MicroRNA-93-5p (miR-93) is a novel oncogenic microRNA (miRNA) and elevated in diverse human malignancies. Aberrant expression dysfunction of miR-93 are involved many types tumours. However, the exact role remains unclear head neck squamous cell carcinoma (HNSCC). The objective this study to determine pattern clinical significance HNSCC. MiR-93 levels 103 primary HNSCC tissues 16 corresponding non-cancerous epithelia were analysed by miRNA situ hybridisation correlated with...
Invasion and metastasis represent the primary causes of therapeutic failure in patients diagnosed with squamous cell carcinoma head neck (SCCHN). Therefore, disease prediction inhibition invasion are critical for enhancing survival SCCHN. Our previous study revealed that increased expression miR-93-5p is associated poor prognosis SCCHN; however, mechanism underlying oncogenic functions SCCHN migration remains unclear. Using qPCR analyses, transwell assays, scratch tests, we demonstrated...
Parkinson's disease (PD) is a common degenerative of the central nervous system (CNS). The main pathological change apoptosis dopaminergic neurons in substantia nigra pars compacta (SNPc), thereby leading to dopamine reduction nigral striatum. 6-Hydroxydopamine (6-OHDA), neurotoxic substance, mediates and causes Parkinson-like symptoms mice.
Metadherin (MTDH) is involved in tumourigenesis and cancer progression multiple human malignancies. However, the MTDH protein has rarely been reported laryngeal squamous cell carcinoma (LSCC). The expression pattern of 176 primary archival LSCC 27 corresponding adjacent noncarcinoma specimens was detected by immunohistochemistry further correlated with clinicopathological parameters. results demonstrated that 161 (91.48%) samples stained positive for MTDH; however, staining barely detectable...