A5100439949- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Nutrition and Health in Aging
- Stroke Rehabilitation and Recovery
- Dysphagia Assessment and Management
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Mesenchymal stem cell research
- Neuroscience and Neuropharmacology Research
- Cardiovascular Syncope and Autonomic Disorders
- Wound Healing and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Health and Disease Prevention
- Neurological Disease Mechanisms and Treatments
- Health and Well-being Studies
- Esophageal and GI Pathology
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Advanced Fluorescence Microscopy Techniques
- 14-3-3 protein interactions
- Cellular transport and secretion
- Clinical Nutrition and Gastroenterology
- Parkinson's Disease Mechanisms and Treatments
- Zebrafish Biomedical Research Applications
Tongji University
2018-2021
Taizhou Fourth People's Hospital
2021
National Health and Family Planning Commission
2019
Second Affiliated Hospital of Zhejiang University
2016
Shanghai First People's Hospital
2002-2016
Shanghai Jiao Tong University
2010
Abstract Whole brain computed tomography perfusion (CTP) has the potential to select eligible patients for reperfusion therapy. We aimed find optimal thresholds on baseline CTP ischemic core and penumbra in acute stroke. reviewed with stroke anterior circulation, who underwent whole CTP, followed by intravenous thrombolysis imaging at 24 hours. Patients were divided into those major (to define core) minimal extent of penumbra). Receiver operating characteristic (ROC) analysis volumetric...
Background and Purpose— We aimed to develop a risk score (intracerebral hemorrhage–associated pneumonia score, ICH-APS) for predicting hospital-acquired stroke-associated (SAP) after ICH. Methods— The ICH-APS was developed based on the China National Stroke Registry (CNSR), in which eligible patients were randomly divided into derivation (60%) validation (40%) cohorts. Variables routinely collected at presentation used SAP For testing added value of hematoma volume measure, we separately 2...
Questions exist regarding the causal relationship between malnutrition and stroke outcomes. This study aimed to determine whether nutritional status changes or during hospitalisation could predict 3-month outcomes in acute patients.During a 10-month period, patients who suffered their first within 7 days after onset were included this prospective multi-centre study. The demographic parameters, risk severity factors, factors dysphagia recorded. Nutritional was assessed by 3 anthropometric...
Background: Parkinson’s disease (PD) is a neurodegenerative disorder displaying typical neuroinflammation pathology that may result from an imbalance between regulatory T cells (Treg) and helper 17 (Th17) cells. Human adipose tissue-derived mesenchymal stem (Ad-MSCs) exert immunomodulatory effects by inhibiting effector cell responses have been used to treat diverse immune disorders. We aimed investigate the modulating effect of human Ad-MSCs on peripheral blood mononuclear (PBMCs) patients...
Objective Leptomeningeal collaterals, which affects tissue fate, are still challenging to assess. Four-dimensional CT angiography (4D CTA) originated from perfusion (CTP) provides the possibility of non-invasive and time-resolved assessment leptomeningeal collateral flow. We sought develop a comprehensive rating system integrate speed extent flow on 4D CTA, investigate its prognostic value for reperfusion therapy in acute ischemic stroke (AIS) patients. Methods retrospectively studied 80...
BackgroundSerotonergic raphespinal neurons and their fibers have been mapped in large mammals, but the non-serotonergic ones not studied, especially mouse. The present study aimed to investigate termination pattern of arising from hindbrain raphe reticular nuclei which also serotonergic by injecting anterograde tracer BDA into them. ResultsWe found that terminate both dorsal ventral horns addition lamina 10. There is a shift horn towards lateral part gray matter. Considerable variation...
Abstract The aim of this study was to evaluate the impact pretreatment quality collaterals, involving velocity and extent collateral filling, on recanalization after intravenous thrombolysis (IVT). A retrospective analysis performed 66 patients with acute middle cerebral artery (MCA) M1 segment occlusion who underwent MR perfusion (MRP) imaging before IVT. filling defined as arrival time delay (ATD) contrast bolus Sylvian fissure between normal affected hemisphere. assessed according Alberta...
Orthostatic hypotension (OH) is a known risk factor for cerebral ischemia, but its correlation with cognitive impairment (CI) not well established.The aim of this study to explore the relationship between OH and CI in elderly.The group consisted 44 patients who presented drowsiness, vertigo, fatigue January 2009 December 2011 (OH group). Eighty-eight healthy elderly were paired those 1:2 based on their education levels (NOH Baseline sociodemographic information cognition-related measures...
Objectives: The present study aimed to examine the prevalence of and risk factors for magnetic resonance (MR) perfusion abnormality in a Chinese population with transient ischemic attack (TIA) normal diffusion-weighted imaging (DWI) findings. Methods: Patients TIA admitted our stroke center between January 2015 October 2017 were recruited study. MRI, including both DWI perfusion-weighted (PWI) , was performed within 7 days symptom onset. Time maximum residue function (Tmax) maps evaluated...
Postsynaptic density – 95 kDa protein (PSD95) is an important molecule on the postsynaptic membrane. It interacts with many other proteins and plays a pivotal role in learning memory formation. Its distribution brain has been studied previously using situ hybridization as well immunohistochemistry. However, these studies are based 2 dimensional (2D) sections results presented few sections. The present study aims to show PSD-95 3 dimensions (3D) without slicing tissue of C57BL/6 mice into...
Objectives. The present study is aimed at investigating the frequency and associated factors of asymmetrical prominent veins (APV) in patients with acute ischemic stroke (AIS). Methods. Consecutive AIS admitted to Comprehensive Stroke Center Shanghai Fourth People’s Hospital between January 2013 December 2017 were enrolled. MRI including diffusion-weighted imaging (DWI), perfusion-weighted (PWI), susceptibility-weighted (SWI) was performed within 12 hours symptom onset. volume evaluated...
To assess the prevalence and potential predictors of MR diffusion perfusion abnormalities in a Chinese population with hemispheric transient ischemic attacks (TIA).Patients temporary (<24 hours) focal cerebral dysfunction probable vascular origin were considered to be candidates for this study emergency room. Those who admitted stroke center Shanghai Fourth People's Hospital affiliated Tongji University between January 2015 December 2018 recruited present study. MRI, including both...
Objective To explore the relationship between orthostatic hypotension (OH) and cognition impairment (CI) in elderly. Methods Forty-four OH patients who visited our hospital due to dizziness, vertigo fatigue during January 2009 December 2011 were enrolled exposed group (OH group), 88 healthy elderly paired 1∶2 control (NOH group). The socio-demographic data cognition-related factors two groups collected at baseline; cognitive function was assessed using mini-mental state examination...
Objective: Hypoperfusion is an important factor determining the prognosis of ischemic stroke patients. The present study aimed to investigate possible predictors hypoperfusion on MRI patients within 7 days onset. Methods: Ischemic patients, admitted comprehensive Stroke Center Shanghai Fourth People's Hospital affiliated Tongji University onset between January 2016 and June 2017, were recruited study. Magnetic resonance imaging (MRI), including both diffusion-weighted (DWI)...