A5101736244- Hemophilia Treatment and Research
- Esophageal Cancer Research and Treatment
- Platelet Disorders and Treatments
- Acute Ischemic Stroke Management
- Lung Cancer Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Plant-based Medicinal Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Medicinal Plants and Bioactive Compounds
- Traditional Chinese Medicine Studies
- Lung Cancer Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- COVID-19 Clinical Research Studies
- Inflammatory mediators and NSAID effects
- Stroke Rehabilitation and Recovery
- Eicosanoids and Hypertension Pharmacology
- Hemoglobinopathies and Related Disorders
- Flavonoids in Medical Research
- Botulinum Toxin and Related Neurological Disorders
- Respiratory viral infections research
- Influenza Virus Research Studies
- Advanced Radiotherapy Techniques
- Neurological Disease Mechanisms and Treatments
- Viral gastroenteritis research and epidemiology
- Colorectal Cancer Treatments and Studies
First Affiliated Hospital of Zhengzhou University
2024-2025
Institute of Hematology & Blood Diseases Hospital
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
Kunming Institute of Zoology
2022-2024
University of Chinese Academy of Sciences
2024
University of Hong Kong
2022-2024
Zhejiang Normal University
2024
Union Hospital
2022-2023
Huazhong University of Science and Technology
2022-2023
Union Hospital
2023
A growing number of studies have investigated the prevalence Molar Incisor Hypomineralization (MIH) around world. The aim this study was to systematically estimate pooled MIH.A comprehensive literature research completed in English and Chinese databases. Random effect models were used calculate prevalence. To address heterogeneity, meta-regression, sensitivity analyzes conducted. Publication bias estimated by trim fill method.Seventy eligible included. MIH 14.2% globally. In subgroup...
Inflammatory cytokine is important in modulating injured diseases. Tumor necrosis factor-α (TNF-α), one of potent inflammatory cytokines, plays a dominant role host defense reaction. However, the concrete effect TNF-α on acute liver injury totally unclear. Here we reported and possible mechanisms induced by carbon tetrachloride (CCl4). SD male rats were equally divided into nine groups. CCl4 (1 ml/kg) was subcutaneously injected rats. Enbrel, inhibitor, intraperitoneally at dose 0, 0.25,...
367 Background: Recently, PD-1 blockades combined with dual chemotherapy regimens in first-line setting exhibited encouraging efficacy for patients ESCC. However, the safety profile of conventional remained unsatisfactory. Therefore, anti-angiogenic tyrosine kinase inhibitors (TKIs) and single regimen might offer a promising strategy. Anlotinib, novel multitarget TKI primarily targeting VEGFR1-3, demonstrated therapeutic activity as combination therapy or second-line monotherapy ESCC China...
Questions exist regarding the causal relationship between malnutrition and stroke outcomes. This study aimed to determine whether nutritional status changes or during hospitalisation could predict 3-month outcomes in acute patients.During a 10-month period, patients who suffered their first within 7 days after onset were included this prospective multi-centre study. The demographic parameters, risk severity factors, factors dysphagia recorded. Nutritional was assessed by 3 anthropometric...
The purpose of this study was to discuss the relationship between blood pressure and prognosis patients with symptomatic intracranial arterial stenosis. Data on 2426 large artery stenosis occlusion who participated in Chinese Intracranial Atherosclerosis (CICAS) were analyzed. According JNC 7 criteria, all classified into one four subgroups: normal, prehypertension, hypertension stage I, II. Poor outcomes defined as death functional dependency (mRS 3-5) at discharge or 1 year. For 70% 99%,...
The continuously arising of SARS-CoV-2 variants has been posting a great threat to public health safety globally, from B.1.17 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.617.2 (Delta) B.1.1.529 (Omicron). emerging or re-emerging the concern is calling for constant monitoring their epidemics, pathogenicity and immune escape. In this study, we aimed characterize replication Alpha Delta variant strains isolated patients infected in Laos. amino acid mutations within spike fragment isolates were...
Abstract Background: Clinical trials demonstrated that immune checkpoint inhibitors (ICIs) combined with antiangiogenic drugs had achieved promising outcomes in the third-line and further treatment metastatic colorectal cancer (mCRC) patients (pts) microsatellite-stable (MSS) or proficient mismatch repair. Radiotherapy (RT) may enhance anti-tumor effect of immunotherapy. However, RT on pts receiving targeted therapy plus ICIs remains unclear. Therefore, this study was aimed to investigate...
To date, sex difference in outcomes among patients with intracranial atherosclerosis (ICAS) has rarely been discussed China as well the world. This study aimed to estimate ICAS Chinese cerebral ischemia patients.We analyzed 1,335 men and women who were enrolled Intracranial Atherosclerosis study. They followed-up for ischemic stroke recurrence, any cause of death, vascular events (including transient attack, hemorrhagic stroke), combined end points events, angina or myocardial infarction,...
To assess the clinical efficacy of Chinese patent medicine for bradyarrhythmia(BA) by using network Meta-analysis method. Relevant randomized controlled trials(RCTs) BA were retrieved from China National Knowledge Infrastructure(CNKI), WanFang Database, VIP database, SinoMed, PubMed and Cochrane Library. The retrieval time ranged commencement each database to February 2019. We completed literature screening data extraction according pre-determined inclusion exclusion criteria. quality...
Abstract Background To analyze and explore the evolution short-term efficacy of neoadjuvant therapy for patients with mid low LARC in Wuhan Union Hospital Cancer Center. Methods Patients diagnosed rectal cancer from January 2015 to December 2021 were collected. The treatment patterns, treatment-related adverse events (AEs) who received analyzed. Chi-square test was used compare differences between groups. Results A total 980 enrolled, over time, proportion receiving gradually increased, mode...
The purpose of this study was to evaluate the selection situation outcome indexes in randomized controlled trials traditional Chinese medicine(TCM) treatment acute ischemic stroke and provide suggestions for future research. In study, four databases three English were searched from January 2017 June 2019. medicine selected according pre-established criteria. Cochrane bias risk assessment tool used quality included studies. A total 20 651 related articles searched, 11 662 ones left after...
To evaluate the methodological quality and reporting of randomized controlled trials(RCTs) published in China Journal Chinese Materia Medica, we searched CNKI webpage to collect RCTs since establishment magazine. The Cochrane risk bias assessment tool was used RCTs. CONSORT 2010 list adopted as evaluating tool. Finally, 184 were included evaluated methodologically, which 97 with quality. For evaluating, 62 trials(33.70%) reported random sequence generation; 9(4.89%) trials allocation...
340 Background: Recently, PD-1 blockades combined with dual chemotherapy in first-line setting exhibited encouraging efficacy for patients ESCC. However, the safety profile of conventional remained unsatisfactory. Therefore, anti-angiogenic tyrosine kinase inhibitors (TKIs) and single regimen might be a promising strategy. Anlotinib, novel multitarget TKI primarily targeting VEGFR1-3, demonstrated therapeutic activity as combination therapy or second-line monotherapy ESCC China clinically....