A5100375926- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Fibroblast Growth Factor Research
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune cells in cancer
- Cancer-related gene regulation
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Neuroblastoma Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
Union Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
Wuhan Union Hospital
2023-2025
Union Hospital
2016-2025
Sichuan Agricultural University
2025
Zhejiang University
2020-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Hebei Medical University
2025
North Sichuan Medical University
2024
Background In locally advanced rectal cancer (LARC), preoperative short-course radiotherapy (SCRT) with delayed surgery has been shown to be as effective long-course chemoradiotherapy, only modest benefits. This study aimed evaluate the efficacy and safety of SCRT combined subsequent CAPOX (capecitabine oxaliplatin) anti-PD-1 antibody camrelizumab in patients LARC. Methods was a prospective, single-arm, phase II trial. Treatment-naïve histologically confirmed T3-4N0M0 or T1-4N+M0...
Abstract Purpose: This study aimed to assess the antitumor activity and safety of neoadjuvant chemotherapy combined with PD-1 inhibitor camrelizumab in patients locally advanced head neck squamous cell carcinoma (HNSCC). Patients Methods: In this single-center, single-arm, phase 2 trial, resectable stage III–IVB HNSCC received [albumin-bound paclitaxel 260 mg/m2 (or docetaxel 75 mg/m2) plus cisplatin mg/m2] 200 mg on day 1 each 21-day cycle for three cycles, followed by surgery, adjuvant...
Autoimmune diseases such as ankylosing spondylitis (AS) can be driven by emerging neoantigens that disrupt immune tolerance. Here, we developed a workflow to profile posttranslational modifications involved in neoantigen formation. Using mass spectrometry, identified panel of cysteine residues differentially modified carboxyethylation required 3-hydroxypropionic acid generate patients with AS. The lysosomal degradation integrin αIIb [ITGA2B (CD41)] carboxyethylated at Cys96 (ITGA2B-ceC96)...
Background Immune checkpoint inhibitors (ICIs) in combination with antiangiogenic drugs have shown promising outcomes the third-line and subsequent treatments of patients microsatellite stable metastatic colorectal cancer (MSS-mCRC). Radiotherapy (RT) may enhance antitumor effect immunotherapy. However, RT exposure on receiving ICIs targeted therapy remains unclear. This study aimed to investigate association between clinical responses fruquintinib (a highly selective tyrosine kinase...
Purpose To evaluate the effectiveness of patient-controlled methylphenidate as compared with placebo in cancer patients fatigue, measured by Functional Assessment for Chronic Illness Therapy-Fatigue (FACIT-F). Patients and Methods a fatigue score at least 4 on scale 0 to 10 (0 = no worst possible fatigue) hemoglobin level g/dL were included. randomly assigned receive 5 mg or every 2 hours needed (maximum four capsules day), 7 days. completed daily diary including study drug record intensity....
Accumulating studies highlight the role of long noncoding RNAs (lncRNAs)/microRNAs (miRNAs)/messenger (mRNAs) as important regulatory networks in various human cancers, including thyroid cancer (TC). This study aimed to investigate a novel network dependent on lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) relation TC development. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot were initially employed detect expression MALAT1,...
Extrusion of neutrophil extracellular traps (NETs), a fundamental host innate immune defense against pathogens, has recently been linked to cancer resistance immunotherapy and distant metastasis. These findings highlight interesting areas cancer-elicited inflammation potential therapeutic strategies. Disrupting existing NETs with DNase I proved enhance the efficacy tumor attenuate metastatic spread. However, systemic biodistribution raises safety issues, potentially impairing infection....
Radioresistance is regarded as the main barrier to effective radiotherapy in lung cancer. However, underlying mechanisms of radioresistance remain elusive. Here, we show that lysine-specific demethylase 4C (KDM4C) overexpressed and correlated with poor prognosis cancer patients. We provide evidence genetical or pharmacological inhibition KDM4C impairs tumorigenesis vitro vivo. Moreover, uncover upregulates TGF-β2 expression by directly reducing H3K9me3 level at promoter then activates...
Abstract Background and Aims Metastasis is the primary cause of cancer mortality, colorectal (CRC) frequently metastasizes to liver. Our previous studies demonstrated critical role KIAA1199 in tumor invasion metastasis CRC. In present study, we described an immune regulatory effect that creates a permissive environment for metastasis. Approach Results Flow cytometry was used examine effects on infiltration cells. Neutrophils T cells were isolated, stimulated, and/or cultured vitro function...
Background Although immune checkpoint blockade (ICB) has been proven to achieve a persistent therapeutic response in various tumor types, only 20%–40% of patients benefit from this treatment. Radiotherapy (RT) can enhance immunogenicity and improve the ICB response, but outcome achieved by combining these two modalities remains clinically unsatisfactory. We previously uncovered that lysine-specific demethylase 4C (KDM4C) is regulator radiosensitivity lung cancer. However, role KDM4C...
Tislelizumab (anti-programmed cell death protein 1 antibody) showed preliminary antitumor activity and tolerability in patients with advanced solid tumors, including hepatocellular carcinoma (HCC). This study aimed to assess the efficacy safety of tislelizumab previously treated HCC.The multiregional phase 2 RATIONALE-208 examined single-agent (200 mg intravenously every 3 weeks) HCC Child-Pugh A, Barcelona Clinic Liver Cancer stage B or C, who had received one more prior lines systemic...
Loss of major histocompatibility complex class I (MHC-I) in tumor cells limits the use immune checkpoint blockade (ICB) colorectal cancer. Nevertheless, regulatory mechanism MHC-I downregulation has not been fully elucidated. Overexpression CEMIP tissues is associated with a poor prognosis Here, this research, we aim to address role mediating expression and investigate underlying mechanisms.Protein levels were analyzed by western blotting. Flow cytometry analysis was used examine cells....
•This is the first phase III trial comparing SCRT followed by immunochemotherapy to LCRT chemotherapy in LARC.•Neoadjuvant CAPOX and camrelizumab significantly improved pCR versus neoadjuvant CAPOX.•Neoadjuvant demonstrated promising efficacy LARC patients with pMMR/MSS.•The treatment arm provides opportunity for organ preservation a watch-and-wait strategy.•No unexpected toxicities were observed, safety profile of was manageable. BackgroundNeoadjuvant short-course radiotherapy (SCRT) (a...
Background/Aims: Acute myocardial infarction (AMI) occurs when blood supply to the heart is diminished (ischemia) for long time; ischemia primarily caused due hypoxia. The present study evaluated effects of non-coding RNA H19 on hypoxic rat H9c2 cells and mouse HL-1 cells. Methods: Hypoxic injury was confirmed by measuring cell viability, migration invasion, apoptosis using MTT, Transwell flow cytometry assays, respectively. expression after hypoxia estimated qRT-PCR. We then measured...
The gut microbiome plays an indispensable role in the occurrence and progression of various diseases. However, its ability to predict gastric cancer (GC) liver metastasis (GCLM) has not been fully identified.
ARX788 is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate with AS269 as cytotoxic payload. In this phase 1 multicenter dose-expansion clinical trial, patients HER2-positive advanced gastric/gastroesophageal junction adenocarcinoma failing to respond prior trastuzumab-based standard treatment were enrolled. Between July 15th, 2019, and March 14th, 2022, 30 participants Twenty-eight (93.3%) experienced at least one drug-related adverse event (AE) 13.3% grade 3...
Mutations in either retinoid isomerase (RPE65) or lecithin-retinol acyltransferase (LRAT) lead to Leber congenital amaurosis (LCA). By using the Lrat(-/-) mouse model, previous studies have shown that rapid cone degeneration LCA was caused by endoplasmic reticulum (ER) stress induced S-opsin aggregation. The purpose of this study is examine efficacy an ER chemical chaperone, tauroursodeoxycholic acid (TUDCA), preserving cones model.Lrat(-/-) mice were systemically administered with TUDCA and...
The present study investigated the effects of Colchicine on gastric carcinoma (GC) cells and explored its possible mechanisms underlying such effects. results MTT colony formation assays showed that (2, 5, 10 ng/ml) markedly inhibited proliferation AGS NCI-N87 in a dose-dependent manner. It also led to reduction cell migration both GC as determined by Transwell assay. Mover, data form Hoechst 33342 staining flow cytometry assay indicated promoted apoptosis cells. In addition, release...