A5008691080- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- AI in cancer detection
- Medical Imaging Techniques and Applications
- Nanoplatforms for cancer theranostics
- Medical Image Segmentation Techniques
- Hippo pathway signaling and YAP/TAZ
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Advanced MRI Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Image Retrieval and Classification Techniques
- Circular RNAs in diseases
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- Salivary Gland Tumors Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Gene expression and cancer classification
- Breast Lesions and Carcinomas
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
Zhejiang Cancer Hospital
2015-2024
Chinese Academy of Sciences
2020-2024
University of Chinese Academy of Sciences
2020-2023
Wannan Medical College
2023
Cancer Hospital of Chinese Academy of Medical Sciences
2022
Zhejiang Chinese Medical University
2012
Shenyang Normal University
2009
Wuhan University
2009
Tislelizumab (anti-programmed cell death protein 1 antibody) showed preliminary antitumor activity and tolerability in patients with advanced solid tumors, including hepatocellular carcinoma (HCC). This study aimed to assess the efficacy safety of tislelizumab previously treated HCC.The multiregional phase 2 RATIONALE-208 examined single-agent (200 mg intravenously every 3 weeks) HCC Child-Pugh A, Barcelona Clinic Liver Cancer stage B or C, who had received one more prior lines systemic...
Background Breast tumor heterogeneity is related to risk factors that lead worse prognosis, yet such has not been well studied. Purpose To predict the Ki‐67 status of estrogen receptor (ER)‐positive breast cancer patients via analysis with subgroup identification based on patterns dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI). Study Type Retrospective study. Population Seventy‐seven ER‐positive were investigated, whom 51 had low expression. Field Strength/Sequence T 1...
Background Increasing evidence has shown that circular RNAs (circRNAs) are involved tumourigenesis and metastasis of hepatocellular carcinoma (HCC); however, progression about its function in HCC is relatively slow. Here, we aimed to investigate whether plasma circRNAs could reflect the tumour-infiltrating lymphocytes (TILs) tumour tissues serve as prognosis biomarker for HCC. Methods Tissue samples patients with were subjected immunohistochemistry staining against CD8 examine TILs. Then,...
Circulating tumor cells (CTCs) usually shed from primary and metastatic tumors serve as an important marker, easily cause fatal distant metastasis in cancer patients. Accurately effectively detecting CTCs a peripheral blood sample is of great significance early diagnosis, efficacy evaluation, postoperative condition monitoring. In this work, TiO2@Ag nanostructure structured SERS substrate, rhodamine 6G (R6G) used Raman signal molecule, the reduced bovine serum protein (rBSA) acts protective...
Abstract Background & Aims We aimed to develop a Transformer‐based deep learning (DL) network for prognostic stratification in hepatocellular carcinoma (HCC) patients undergoing RFA. Methods A Swin Transformer DL was trained establish associations between magnetic resonance imaging (MRI) datasets and the ground truth of microvascular invasion (MVI) based on 696 surgical resection (SR) with solitary HCC ≤3 cm, validated an external cohort ( n = 180). The multiphase MRI‐based risk outputs...
To investigate the feasibility of applying a new quantitative image analysis method to improve breast cancer diagnosis performance using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) by integrating background parenchymal enhancement (BPE) features into decision making process.A dataset involving 115 DCE-MRI examinations was used in this study. Each examination depicts one identified suspicious tumor. Among them, 75 cases were verified as malignant and 40 benign biopsy...
Circulating tumor cells (CTCs) can be the seeds of metastasis and are closely linked to cancer-related death. Fast effective detection CTCs is important for early diagnosis cancer evaluation micrometastasis. However, extreme rarity heterogeneity in peripheral blood make sensitive a big challenge. In this paper, TiO2-based surface-enhanced Raman scattering (SERS) bioprobe reported first time with outstanding ultrasensitive specificity, excellent stability signal, good biocompatibility CTCs....
The efficiency of immunotherapy for triple-negative breast cancer (TNBC) is relatively low due to the difficulty in accurately detecting immune checkpoints. detection TNBC-related programmed cell death ligand-1 (PD-L1) expression important guide and improve treatment efficiency. Surface-enhanced Raman spectroscopy (SERS) magnetic resonance (MR) imaging exhibit great potential early TNBC diagnosis. SERS, an optical mode, has advantages high sensitivity, good spatial resolution, "fingerprint"...
Purpose To accurately assess disease progression after Stereotactic Ablative Radiotherapy (SABR) of early-stage Non-Small Cell Lung Cancer (NSCLC), a combined predictive model based on pre-treatment CT radiomics features and clinical factors was established. Methods This study retrospectively analyzed the data 96 patients with NSCLC treated SABR. Clinical included general information (e.g. gender, age, KPS, Charlson score, lung function, smoking status), lesion status diameter, location,...
This study aimed to investigate the efficacy, safety, and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. A total 367 cancer from 24 medical centers were consecutively enrolled this multiple-center, prospective cohort study, including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) 55 secondary cases. All received CalliSpheres ® DEB-TACE treatment. Treatment response,...
Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide, however, prognosis for HCC remains unsatisfactory. This study aimed to explore role miR-339-5p in HCC. Methods: We first used quantitative real-time PCR examine level tissues. Then we further adopted Western blotting assay, CCK8, cell invasion assays, apoptosis detection and luciferase assay analyze how it mediate development Results: found that miR-339 significantly decreased primary...
To establish a diagnostic model by combining imaging features with enhanced CT texture analysis to differentiate pancreatic serous cystadenomas (SCNs) from mucinous (MCNs).Fifty-seven and 43 patients pathology-confirmed SCNs MCNs, respectively, one center were analyzed divided into training cohort (n = 72) an internal validation 28). An external 28) another was allocated. Demographic radiological information collected. The least absolute shrinkage selection operator (LASSO) recursive feature...
Liver cancer is one of the most common malignant human tumors with highest morbidity and mortality rates all types in China. Evidence suggests that long non‑coding RNA prostate cancer‑associated transcript 6 (PCAT6) plays an essential role tumor progression. However, roles mechanism PCAT6 liver remain unclear. The present study showed expression heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) was upregulated tissues compared non‑cancerous were associated poor overall survival time,...
Purpose: To evaluate the advantages and primary technical efficacy of an electromagnetic (EM) navigation system for computed tomography (CT)-guided thermal ablation liver tumors.Material methods: From August 2016 to January 2018, 40 patients scheduled CT- guided were prospectively enrolled divided into two groups. Twenty underwent CT-guided with EM (navigation group), while other 20 conventional (control group). Data on skin punctures, instrument adjustments, puncture time target, CT scans,...