A5044630722- Pancreatic and Hepatic Oncology Research
- Phytochemicals and Antioxidant Activities
- Advancements in Transdermal Drug Delivery
- Antioxidant Activity and Oxidative Stress
- Neuroendocrine Tumor Research Advances
- Free Radicals and Antioxidants
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Lung Cancer Research Studies
- Contact Dermatitis and Allergies
- Immune Response and Inflammation
- Ginseng Biological Effects and Applications
- Herbal Medicine Research Studies
- Pharmacological Effects of Natural Compounds
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Indoor Air Quality and Microbial Exposure
- Neuroblastoma Research and Treatments
- Renal cell carcinoma treatment
- Advanced X-ray and CT Imaging
- Acne and Rosacea Treatments and Effects
- Allergic Rhinitis and Sensitization
- NF-κB Signaling Pathways
Beijing Technology and Business University
2019-2025
Nanchang University
2018-2025
State Key Laboratory of Plant Genomics
2020-2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
Aerospace Information Research Institute
2024
University of Chinese Academy of Sciences
2024
State Key Laboratory of Transducer Technology
2024
State Key Laboratory of Food Science and Technology
2016-2024
Yuhuangding Hospital
2024
Weifang Medical University
2024
Existing nanoparticle-mediated drug delivery systems for glioma systemic chemotherapy remain a great challenge due to poor efficiency resulting from the blood brain barrier/blood-(brain tumor) barrier (BBB/BBTB) and insufficient tumor penetration. Here, we demonstrate distinct design by patching doxorubicin-loaded heparin-based nanoparticles (DNs) onto surface of natural grapefruit extracellular vesicles (EVs), fabricate biomimetic EV-DNs, achieving efficient thus significantly enhancing...
Extracellular vesicles (EVs) have recently received much attention about the application of drug carriers due to their desirable properties such as nano-size, biocompatibility, and high stability. Herein, we demonstrate orange-derived extracellular (OEV) nanodrugs (DN@OEV) by modifying cRGD-targeted doxorubicin (DOX) nanoparticles (DN) onto surface OEV, enabling significantly enhancing tumor accumulation penetration, thereby efficiently inhibiting growth ovarian cancer. The obtained DN@OEV...
This study aimed to elucidate the effect of tyrosol (TYR) on amelioration nonalcoholic fatty liver disease (NAFLD).
Euchlorocystis marina , a new marine species of the genus discovered in 2022, has potential to improve water quality mariculture ponds. However, effects salinity on growth, physiology, and biochemical composition these algae are not well understood. In this study, changes physiological indices such as cell density, photosynthetic pigment, polysaccharide, lipid content E. under different treatments were analyzed. The results showed that highest density was observed at 15‰. lowest pigment 60‰,...
Lotus seed epicarp (LSE) and lotus pot (LSP) were characterized, a total of 5 7 proanthocyanidins (PAs) identified in purified LSE LSP extract, respectively. Purified PAs significantly suppressed the body weight gain white adipose tissue (WAT) decreased WAT cell size high-fat diet-induced obese mice regardless daily food intake. or administration lowered serum leptin level improved liver lipid profiles (including cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol...
The cancer treatments that target tumor associated angiogenesis (TAA) induced by vascular endothelial growth factor A (VEGFA) have become valued. Ginsenoside Rh2 has been proved to inhibit TAA through VEGFA. However, the underlying mechanisms remain unclear. Moreover, octyl ester derivative of (Rh2-O) exhibited better inhibitory effects than on liver in our previous researches, which indicated Rh2-O might also exert TAA. To explore and investigate mechanisms. were evaluated conditioned...
ABSTRACT Background Skin aging results in skin barrier damage and wrinkles. Oral Colla Corii Asini (CCA) can show significant antiaging effects. However, few studies have investigated the skin's effects of topical CCA. Here, we compared CCA crushed (CCAC) its enzymatic digest, oligopeptide (CCAO), on function wrinkle formation. Methods CCAO CCAC were prepared by digestion pulverization. HaCaT cells HSF selected as vitro cell models. Cytotoxicity proliferation detected MTT assay; scratch...
Cinnamaldehyde (CIN), which is a cosmetic fragrance allergen regulated by the European Union, can induce allergic contact dermatitis in consumers, reducing their quality of life. Autophagy may be associated with dendritic cell (DC) response to chemical sensitizers. We hypothesized that CIN would activate DCs through autophagy during skin sensitization. In this study, Tohoku Hospital Pediatrics-1 cells (THP-1 cells) were used as an vitro DC model, and we evaluated expression activation...
Streptococcus suis (S. suis) and Glaesserella parasuis (G. parasuis) are prevalent pathogens in pig populations often associated with co-infections, leading to substantial economic losses the swine industry. However, there is currently a shortage of rapid detection methods. In this study, dual loop-mediated isothermal amplification combined lateral flow dipstick (LAMP-LFD) assay was developed for simultaneous convenient S. G. parasuis. The utilized primers targeting conserved regions gdh...
Abstract Phenolics and carotenoids coexist in fruits vegetables could possess interaction effects after consumption. The present study aims to elucidate the possible mechanisms of antioxidant interactions between anthocyanins using petunidin lycopene as examples hydrogen peroxide (H 2 O )‐induced heart myofibroblast cell (H9c2) line model. results revealed that showed a larger proportion mixed with lycopene, for example, petunidin: = 9:1 significantly protected against loss viability (8.98 ±...
Abstract Background Preservatives represent one of the main causes skin irritation and contact allergies. Aims To comprehensively evaluate potential phenoxyethanol, methylparaben, propylparaben, imidazolidinyl urea, DMDM hydantoin under regulatory acceptable concentrations. Methods A patch test repeated open application (ROAT) were applied to in vivo. In vitro alternative methods consisting keratinocyte cytotoxicity assay, red blood cell (RBC) test, hen's egg test‐chorioallantoic membrane...
The hydrophilic extracts of eggplant peel (HEEP) and purple sweet potato (HEPP) lipophilic tomato (LET) carrot (LEC) were mixed in different ratios to assess the significance compatibility aliments, based on their antioxidant anti-inflammatory interactions H9c2 cells. results indicated that groups some combinational (HEPP-HEEP F1/10, LEC-HEEP F3/10, LEC-HEPP F3/10) showed stronger synergistic effects than individual groups. For example, glutathione peroxidase (GPx) activity (F3/10) group...
The hydrophilic extracts of mulberry (HEM) and blueberry (HEB) lipophilic mango (LEM) watermelon (LEW) were mixed in different ratios to assess the antioxidant interactions by chemical-based (DPPH ABTS assays) H9c2 cell-based models. There both synergistic antagonistic among these fruits. Some groups with combinational showed stronger effects than individual groups, others (HEM-LEW F1/10, LEW-LEM F5/10, HEB-LEM F3/10) based on indicators [the values DPPH, ABTS, MTT; expression superoxide...
To establish a diagnostic model by combining imaging features with enhanced CT texture analysis to differentiate pancreatic serous cystadenomas (SCNs) from mucinous (MCNs).Fifty-seven and 43 patients pathology-confirmed SCNs MCNs, respectively, one center were analyzed divided into training cohort (n = 72) an internal validation 28). An external 28) another was allocated. Demographic radiological information collected. The least absolute shrinkage selection operator (LASSO) recursive feature...
The semiactive or inactive probiotics their extracts used in dermatology have interesting properties to ameliorate signs of irritated skin and enhance the barrier. Bifidobacterium, as most common probiotics, which has been found be effective reducing acne improving barrier function atopic dermatitis. Bifida Ferment Lysate (BFL) can obtained from Bifidobacterium by fermentation extraction.In this study, we investigated effect a topically BFL on using vitro evaluation methods.The results...