A5100327621- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cholesterol and Lipid Metabolism
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- Liver physiology and pathology
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
- Cancer Mechanisms and Therapy
- Pulmonary Hypertension Research and Treatments
- Liver Disease and Transplantation
- HIV/AIDS drug development and treatment
- Cancer, Hypoxia, and Metabolism
- Platelet Disorders and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis C virus research
- Fibroblast Growth Factor Research
Fudan University
2013-2025
Shanghai Jiao Tong University
2025
The First Affiliated Hospital, Sun Yat-sen University
2012-2025
Zhongshan Hospital
2012-2025
Sun Yat-sen University
2012-2025
Shandong University of Traditional Chinese Medicine
2023-2025
Shuguang Hospital
2023-2025
Shanghai University of Traditional Chinese Medicine
2023-2025
Nanjing Medical University
2020-2024
People's Hospital of Cangzhou
2024
Pulmonary arterial hypertension (PAH) is a progressive disorder that can lead to right ventricular failure and severe consequences. Despite extensive efforts, limited progress has been made in preventing the progression of PAH. Mitochondrial dysfunction implicated development PAH, but key mitochondrial functional alterations pathogenesis have yet be elucidated. We integrated three microarray datasets from Gene Expression Omnibus (GEO), including 222 lung samples (164 58 controls), for...
Findings from observational studies indicate an association of thyroid hormone levels with the risk nonalcoholic fatty liver disease (NAFLD); however, conflicting results remain and reverse causality may be a possibility.This study aimed to evaluate associations between NAFLD both plasma thyroxine (T4) stimulating (TSH) at phenotypic genetic levels.We included 14 797 participants, aged 20 74 years who had undergone abdominal ultrasonography during Third National Health Nutrition Examination...
To investigate the preoperative predictive value of non-invasive imaging biomarkers for programmed cell death protein 1/programmed ligand 1 (PD-1/PD-L1) expression and outcome in intrahepatic cholangiocarcinoma (ICC) using machine learning.PD-1/PD-L1 98 ICC patients was assessed by immunohistochemistry, their prognostic effects were analysed Cox regression Kaplan-Meier analysis. Radiomic features extracted from MRI arterial portal vein phases, three sets Radiomics score (Radscore) with good...
While the correlation between PD-L1 expression and KRAS mutation has been previously reported in other solid tumors such as non-small cell lung cancer (NSCLC), whether can be modulated by ERK signaling downstream of intrahepatic cholangiocarcinoma (iCCA) underlying molecular regulatory mechanism remain unclear.The ERK, p-ERK, autophagy markers following knockdown or Ras/Raf/MEK/ERK inhibitors treatment was examined two human iCCA lines (HuCCT1 RBE) using western blotting immunofluorescence....
Intrahepatic cholangiocarcinoma (iCCA) can originate from the large bile duct group (segment ducts and area ducts), small (septal interlobular terminal (bile ductules canals of Hering) intrahepatic biliary tree, which be histopathological corresponding to type iCCA, iCCA with ductal plate malformation pattern, cholangiolocarcinoma, respectively. The challenge in pathological diagnosis above subtypes falls distinction cellular morphologies, tissue structures, growth patterns, invasive...
The complement system can be activated spontaneously for immune surveillance or induced to clear invading pathogens, in which the membrane attack complex (MAC, C5b-9) plays a critical role. CD59 is sole regulatory protein (mCRP) that restricts MAC assembly. CD59, therefore, protects innocent host cells from attacks by system, and require constitutive inducible expression of protect themselves deleterious destruction complement. However, mechanisms underlie regulation remain largely unknown....
Gallic acid (GA), a natural organic phenolic compound, is an abundant plant food bioactive substance present in many medicinal herbs. GA has anti-oxidative, anti-inflammatory and anticancer activities on multiple metabolic disorders. The study was carried out to uncover the alleviating effects of dysfunction-associated steatohepatitis (MASH) underlying mechanisms its action. In this study, mouse model MASH induced by high-fat high-carbohydrate diet used test impact We found that...
Abstract Introduction: MET mutations have been linked with highly progressive clinical behaviors and poor prognosis in several tumor types. Savolitinib (also known as AZD6094, HMPL-504 volitinib) is a novel, potent, selective inhibitor investigated solid tumors. Methods: This an open-label, single arm, multi-center phase II study to evaluate the efficacy safety of savolitinib exon 14 skipping mutant PSC or other types NSCLC (NCT02897479). Eligible patients (pts) were diagnosed unresectable...
Abstract Aim This study aimed to investigate the mechanisms through which diosgenin inhibits pathogenesis of non‐alcoholic fatty liver disease, focusing particularly on ferroptosis‐related pathways and its reliance nuclear factor erythroid 2‐related 2 . Materials Methods Using a rat model, we showed diosgenin's efficacy in reducing lipid deposition throughout body examined impact gene expression vivo Moreover, vitro experiments using human hepatocellular carcinoma cell line cells were...
Ubiquitin C-terminal hydrolase-L1 (UCH-L1), an important member of de-ubiquitination enzyme families involved in the ubiquitin-proteasome pathway, is expressed mainly neural and reproductive systems as well some tumours. Recently, expression UCH-L1 has been discovered parietal epithelial cells Bowman's capsules tubular epithelia kidney. However, whether capillary tufts glomeruli not yet become clear. In this study, we used immunohistochemistry, double immunofluorescence labelling,...
Sterol regulatory element-binding protein-1c (SREBP-1c) increases lipogenesis at the transcriptional level, and its expression is upregulated by liver X receptor α (LXRα). The LXRα/SREBP-1c signaling may play a crucial role in pathogenesis of nonalcoholic fatty disease (NAFLD). We previously reported that cholesterol metabolite, 5-cholesten-3β,25-diol 3-sulfate (25HC3S), inhibits LXRα reduces decreasing SREBP-1c primary hepatocytes. present study aims to investigate effects 25HC3S on lipid...
Cytosolic sulfotransferase 2B1b (SULT2B1b) catalyzes the sulfation of 3β-hydroxysteroids and functions as a selective cholesterol oxysterol sulfotransferase. Activation liver X receptors (LXRs) by oxysterols has been known to be an antiproliferative factor. Overexpression SULT2B1b impairs LXR's response oxysterols, which it regulates lipid metabolism. The aim this study was investigate in vivo vitro effects on proliferation underlying mechanisms. Primary rat hepatocytes C57BL/6 mice were...