A5101464225- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Hepatitis C virus research
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Angiogenesis and VEGF in Cancer
- Cardiac tumors and thrombi
- Glutathione Transferases and Polymorphisms
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Myasthenia Gravis and Thymoma
- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
Shandong First Medical University
2012-2024
Shandong Tumor Hospital
2011-2024
Academy of Medical Sciences
2022
Nanjing Institute of Railway Technology
2018
New Technology (Israel)
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2013
This study was aimed to evaluate the efficacy and safety of transarterial chemoembolization combined with tyrosine kinase inhibitors camrelizumab in treatment unresectable hepatocellular carcinoma explore a new therapeutic strategy for advanced HCC.A total 87 patients aged 18-75 years at least one measurable lesion per Response Evaluation Criteria Solid Tumors (version 1.1) were included study. TACE administered as needed, TKI medication initiated within two weeks week after TACE,...
MicroRNAs (miRNAs) are thought to have a role in cancer development. We investigated the association among miR-146a G>C genetic variations, hepatitis B (HBV), and C (HCV) infection, risk of hepatocellular carcinoma (HCC). Unconditional logistical regression analysis suggested that GG genotype G allele carried 2.10- (95 % confidence interval (CI)=1.03-4.37) 1.42-fold CI=1.07-1.92) increased HCC risk, respectively. HBV-positive subjects carrying (odds ratio (OR)=2.95, 95 CI=1.31-6.81)...
Glutathione S-transferases (GSTs) are enzymes which play an important role in the neutralization of toxic compounds and eradication electrophilic carcinogens.Genetic polymorphisms within genes encoding for GSTs may therefore cause variations their enzyme activity, turn influence interindividual susceptibility to cancers.In this study, we aimed investigate association between genetic GSTT1, GSTM1, GSTP1 risk colorectal cancer (CRC) 264 cases 317 controls a Chinese population.Genotyping was...
Sorafenib has been demonstrated to improve survival rate in patients with advanced hepatocellular carcinoma (HCC); however, the benefit remains modest and response rates remain poor. Transarterial chemoembolization (TACE) may be used for treatment of HCC well‑preserved liver function a high local tumor control rate. We hypothesized that from combination sorafenib TACE. A retrospective study was conducted involving HCC, who had received at least one TACE session. Patients subsequently 400 mg...
Hepatocellular carcinoma (HCC) is a globally common neoplasm, with regional metastasis associated >50% of the tumors. Extrahepatic also common, lungs, diaphragm, abdominal lymph nodes and bone being most frequently affected regions. However, to best our knowledge, HCC lacrimal gland has not been reported in literature. Only one case sac from renal cell reported. The current study presents 56-year-old male ocular symptoms who was eventually diagnosed HCC. therapeutic alternatives for such...
Positron emission tomography (PET) using 18F‑fluorodeoxyglucose has been widely used for analyzing cellular metabolism. The present study aimed to evaluate the association between diagnostic value of PET/computed (CT) in patients with post‑operative recurrent and metastatic colorectal cancer (CRC), different levels carcinoembryonic antigen (CEA). A total 105 suspected CRC (67 males 38 females; mean age, 48.5 years) were included this retrospective study. All underwent PET/CT examination....
To evaluate the efficacy and safety of raltitrexed plus oxaliplatin-based transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (HCC). A total 123 HCC were recruited into prospective cohort study. Raltitrexed TACE was performed according to traditional method at monthly intervals repeated for up 4 cycles if no disease progression or intolerable toxicity occurred. The primary endpoint overall survival (OS), secondary endpoints progression-free (PFS)...
The purpose of this study was to compare positional and volumetric differences planning target volumes (PTVs) defined on axial three dimensional CT (3D CT) four (4D for liver cancer. Fourteen patients with cancer underwent 3D 4D simulation scans during free breathing. tumor motion measured by CT. Three internal (ITVs) were produced based the clinical volume from 3DCT (CTV3D): i) A conventional ITV (ITVconv) adding 10 mm in CC direction 5 LR AP directions CTV3D; ii) specific (ITVspec) created...
The liver is the most common site of colorectal cancer metastases. present study aimed to evaluate efficacy and safety transarterial chemoembolization (TACE) with raltitrexed oxaliplatin for metastases in a prospective, multicenter, single-arm trial conducted 12 hospitals from different areas China. A total 90 patients were enrolled treated by TACE 4 mg 100 mg, followed embolotherapy 50 5-20 ml lipiodol, administered every 28 days four cycles. Patients up 3 months after treatment months....
This study was to identify risk factors affecting postembolization fever (PEF) of CalliSpheres drug-eluting bead transarterial chemoembolization (DEB-TACE) in the treatment primary hepatocellular carcinoma (HCC).One hundred eighty-eight consecutive patients with HCC who underwent DEB-TACE between June 2017 and May 2019 were included this retrospective study. The divided into 4 groups based on severity posttransarterial (TACE) according degrees body temperature. Univariate analysis...
4079 Background: Combined systemic and local therapy is a promising treatment strategy for patients with advanced hepatocellular carcinoma (HCC). Transarterial chemoembolization (TACE), tyrosine kinase inhibitors (TKI) PD-1 antibodies are all recommended unresectable HCC (uHCC). This study was aimed to evaluate the efficacy safety of TACE combined TKIs camrelizumab in uHCC. Methods: In this multicenter, single-arm phase II trial (ChiCTR2000039508), intermediate-stage uHCC who had Child-Pugh...
In the past, patients with liver cancer who lost surgical treatment were mainly treated sorafenib and other therapeutic means. Donafinib is an updated version of also only monotherapy drug to date that has been superior in OS a first-line head-to-head study advanced HCC. This aimed evaluate safety efficacy transarterial chemoembolization (TACE) combined donafenib real word cohort intermediate hepatocellular carcinoma. Prospective analysis 27 or primary HCC at from Shandong Cancer Hospital...
This case underscores the pivotal role of early cytological examination bodily fluids in preliminary detection lymphoma, a conclusion reinforced by subsequent pathological findings and refined through immunohistochemical characterization. A morphological analysis pleural effusion cells was conducted 25-year-old male presenting initially with concurrent pericardial effusions. Initial assessment specimens indicated likelihood lymphoproliferative disorder. Subsequent detailed investigations...
To investigate the outcome difference of whole brain radiotherapy (WBRT) and involved-field (IFRT) in limited-stage small-cell lung cancer (LS-SCLC) patients with recurrent metastases (BMs) after prophylactic cranial irradiation (PCI).A retrospective analysis was carried out 68 LS-SCLC who underwent WBRT or IFRT owing to occurrence BMs PCI from 2009 2020.The median overall survival (OS) all 11.43 months [95% confidence interval (CI) 9.39-13.48 months]. In paired comparison OS, group had a...
e16105 Background: Combined systemic and local therapy is a promising treatment strategy for patients with advanced hepatocellular carcinoma (HCC). Transarterial chemoembolization (TACE), tyrosine kinase inhibitors (TKI) PD-1 antibodies are all recommended unresectable HCC (uHCC). This study was aimed to evaluate the efficacy safety of TACE combined TKIs camrelizumab in uHCC. Methods: In this multicenter, single-arm phase II trial (ChiCTR2000039508), intermediate-stage uHCC who had...