A5101966232- Plant Pathogens and Fungal Diseases
- Fungal Biology and Applications
- Cancer, Lipids, and Metabolism
- Yeasts and Rust Fungi Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Clusterin in disease pathology
- Cancer Research and Treatments
- RNA Research and Splicing
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Nuclear Structure and Function
- Bioactive natural compounds
- Oral and gingival health research
- Machine Learning in Bioinformatics
- Fermentation and Sensory Analysis
- Gene expression and cancer classification
- Plant and Fungal Interactions Research
- Ubiquitin and proteasome pathways
- Kruppel-like factors research
- Signaling Pathways in Disease
- Bioactive Compounds and Antitumor Agents
Shandong Tumor Hospital
2010-2025
Shandong First Medical University
2010-2025
Shandong University
2018-2025
Tsinghua University
2023
Chinese Academy of Agricultural Sciences
2023
Institute of Plant Protection
2023
Ministry of Agriculture and Rural Affairs
2023
Center for Life Sciences
2023
Agricultural Genomics Institute at Shenzhen
2023
Abstract Notable-HCC (NCT05185531) is a phase 1b trial, aiming to evaluate the safety and preliminary effectiveness of neoadjuvant PD-1 blockade plus stereotactic body radiotherapy (SBRT) in early-stage resectable hepatocellular carcinoma (HCC). Twenty patients with HCC BCLC stage 0-A received 3 $$\times $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mo>×</mml:mo> </mml:math> Gy SBRT two cycles tislelizumab, an anti-PD-1 monoclonal antibody before curative resection....
Increasing evidence has demonstrated that small noncoding microRNAs (miRNAs) could contribute to cancer development and progression. Besides, they are differentially expressed in human tumor tissues. In the current study, we found miR-320 was significantly downregulated osteosarcoma tissues, compared with adjacent normal Introduction of mimics into U2OS MG63 cells inhibited cell proliferation, while apoptosis rate remained unaltered. Additionally, overexpression also suppress growth nude...
To evaluate the effect of absolute peripheral blood monocyte count (AMC) on risk synchronous colorectal liver metastasis (synCRLM). AMC as well other baseline clinical characteristics between synCRLM+ group (with synCRLM) and synCRLM - (without were measured. Taking 0.47 × 109/L cut-off value, prevalence was compared AMC-high level (AMC ≥ 109/L) AMC-low 109/L); significant predictors for analyzed by logistic regression analysis. The value synCRLM- significantly lower than that in group....
e16222 Background: Advanced metastatic ICC was characterized by poor survival and limited therapeutic options. Surufatinib, a selective tyrosine kinase inhibitor targeting VEGFR 1, 2, 3, FGFR1, CSF-1R, provides dual anti-tumor action via anti-angiogenesis tumor microenvironment regulation. Surufatinib combined with immunotherapy chemotherapy may enhances anti-cancer effects for advanced ICC. This study evaluates the effectiveness safety of surufatinib gemcitabine, cisplatin, immune...
Hepatocellular carcinoma (HCC) is regarded as a leading cause of cancer-related deaths, and its progression associated with hypoxia the induction hypoxia-inducible factor (HIF). Meloxicam, selective cyclooxygenase-2 (COX-2) inhibitor, induces cell death in various malignancies. However, underlying mechanism remains to be elucidated HCC, especially under hypoxic conditions. The alteration COX-2 HIF-1 α oncogenicity was evaluated HCC specimens by tissue microarray. Cell viability, angiogenesis...
Recurrence and metastasis are the two leading causes of poor prognosis in patients with hepatocellular carcinoma (HCC). Secreted clusterin (sCLU) is a stress-induced chaperone that overexpressed HCC. However, precise molecular mechanisms sCLU HCC invasion migration largely unknown. In present study, it was indicated downregulation significantly alleviated invasiveness whereas overexpression notably enhanced number invasive cells via mediating expression level MMP-2 E-cadherin Bel-7402...
Secretory clusterin (sCLU) is overexpressed in cancer and associated with resistance to chemotherapy several types of cancer, including hepatocellular carcinoma (HCC). Sorafenib (SOR), a multikinase inhibitor Raf/mitogen‑activated protein kinase kinase/extracellular signal‑regulated (ERK) signaling the receptor tyrosine kinase, recognized as standard therapeutic strategy for patients advanced HCC. However, role sCLU HCC SOR remains be fully elucidated. In present study, was silenced by CLU...
The T7 peptide, an active fragment of full‑length tumstatin [the non‑collagenous 1 domain the type IV collagen α3 chain, (IV) NC1], has exhibited potential antitumor effects in several types cancer cells. However, mechanism underlying its action against human hepatocellular carcinoma (HCC) remains unclear. present study aimed to investigate role autophagy peptide‑induced cytotoxicity HCC cells vitro and vivo. results revealed that peptide significantly reduced cell viability induced cycle...
The maize anthracnose stalk rot and leaf blight diseases caused by the fungal pathogen Colletotrichum graminicola is emerging as an important threat to corn production worldwide. In this work, we provide improved genome assembly of a C. strain (TZ-3) using PacBio Sequel II Illumina high-throughput sequencing technologies. TZ-3 consists 36 contigs with length 59.3 Mb. After correction evaluation data BUSCO, showed high quality integrity. Gene annotation predicted 11,911 protein-coding genes,...
Not Abstract.