A5072847679- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Radiology practices and education
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Ultrasound in Clinical Applications
- Gallbladder and Bile Duct Disorders
- Radiomics and Machine Learning in Medical Imaging
- Innovations in Medical Education
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Artificial Intelligence in Healthcare and Education
- Renal cell carcinoma treatment
- Medical Imaging Techniques and Applications
- Organ Transplantation Techniques and Outcomes
- Cardiac Imaging and Diagnostics
- Pancreatic and Hepatic Oncology Research
- MRI in cancer diagnosis
- Gastric Cancer Management and Outcomes
- Hepatitis B Virus Studies
- Nutrition and Health in Aging
- Abdominal vascular conditions and treatments
- Inflammatory Biomarkers in Disease Prognosis
University of Lübeck
2022-2025
University Hospital Schleswig-Holstein
2022-2025
University Medical Center of the Johannes Gutenberg University Mainz
2015-2024
Johannes Gutenberg University Mainz
2015-2024
German Centre for Cardiovascular Research
2024
Institute for Integrative and Experimental Genomics
2024
Ludwig-Maximilians-Universität München
2024
University Medical Center
2020-2021
University Hospital and Clinics
2020
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2008-2020
To evaluate the incidence, management, and outcome of visceral artery aneurysms (VAA) over one decade.233 patients with 253 VAA were analyzed according to location, diameter, aneurysm type, aetiology, rupture, outcome.VAA localized at splenic artery, coeliac trunk, renal hepatic superior mesenteric other locations. The aetiology was degenerative, iatrogenic after medical procedures, connective tissue disease, others. rate rupture much higher in pseudoaneurysms than true (76.3% vs.3.1%)....
Background Automation bias (the propensity for humans to favor suggestions from automated decision-making systems) is a known source of error in human-machine interactions, but its implications regarding artificial intelligence (AI)–aided mammography reading are unknown. Purpose To determine how automation can affect inexperienced, moderately experienced, and very experienced radiologists when mammograms with the aid an (AI) system. Materials Methods In this prospective experiment, 27 read...
Background The coronavirus disease 2019 (COVID-19) pandemic led to far-reaching restrictions of social and professional life, affecting societies all over the world. To contain virus, medical schools had restructure their curriculum by switching online learning. However, only few implemented such novel learning concepts. We aimed evaluate students’ attitudes provide a broad scientific basis guide future development education. Methods Overall, 3286 students from 12 different countries...
Abstract Intratumor heterogeneity may result from the evolution of tumor cells and their continuous interactions with microenvironment which collectively drives tumorigenesis. However, an appearance cellular molecular creates a challenge to define features linked malignancy. Here we perform multiregional single-cell RNA sequencing (scRNA-seq) analysis seven liver cancer patients (four hepatocellular carcinoma, HCC three intrahepatic cholangiocarcinoma, iCCA). We identify dynamics malignant...
Background Coronary CT angiography is a first-line test in coronary artery disease but limited by severe calcifications. Photon-counting-detector (PCD) improves spatial resolution. Purpose To investigate the effect of improved resolution on stenosis assessment and reclassification. Materials Methods stenoses were evaluated prospectively vessel phantom (in vitro) containing two (25%, 50%), retrospectively patients vivo) who underwent ultrahigh-spatial-resolution cardiac PCD (from July 2022 to...
Randomized controlled trials (RCTs) represent the gold standard for evidence generation across all areas of medicine and especially in oncology field, as they allow unbiased estimates treatment effect without confounders. Observational studies have many problems that could reduce their internal external validity. However, large prospective (well-conducted) observational real-world (RWS) can detect occurrence rare adverse events or monitoring long-term events. Impact Real Word Data (RWD),...
Calcium blooming causes stenosis overestimation on coronary CTA.
To compare the overall survival of patients with hepatocellular carcinoma (HCC) who were treated lipiodol-based conventional transarterial chemoembolization (cTACE) that drug-eluting bead (DEB-TACE). By an electronic search our radiology information system, we identified 674 received TACE between November 2002 and July 2013. A total 520 cTACE, 154 DEB-TACE. In total, 424 excluded for following reasons: tumor type other than HCC (n = 91), liver transplantation after 119), lack histological...
To prospectively compare SIRT and DEB-TACE for treating hepatocellular carcinoma (HCC). From 04/2010–07/2012, 24 patients with histologically proven unresectable N0, M0 HCCs were randomized 1:1 to receive or DEB-TACE. could be repeated once in case of recurrence; while, TACE was every 6 weeks until no viable tumor tissue detected by MRI contraindications prohibited further treatment. Patients followed-up 3 months; the final evaluation 05/2013. Both groups comparable demographics (SIRT:...
Photon-counting detector computed tomography (PCD-CT) has the potential to significantly improve CT imaging in many ways including, but not limited to, low-dose high-resolution (HRCT) of lung. The aim this study was perform an intrapatient comparison radiation dose and image quality PCD-CT compared with conventional energy-integrating (EID-CT).A total 32 consecutive patients available EID-CT HRCT scans were included final analysis. index (CTDI vol ) extracted from patient reports....
The aim of this study was to evaluate strategies reduce contrast media volumes for coronary computed tomography (CT) angiography on a clinical first-generation dual-source photon-counting detector (PCD)-CT system using dynamic circulation phantom.Coronary CT angiograph is an established method the assessment artery disease that relies administration iodinated media. Reduction while maintaining diagnostic image quality desirable. In study, phantom containing 3-dimensional-printed model...
Background CT-guided high-dose-rate (HDR) brachytherapy (hereafter, HDR brachytherapy) has been shown to be safe and effective for patients with unresectable hepatocellular carcinoma (HCC), but studies comparing this therapy other local-regional therapies are scarce. Purpose To compare patient outcomes of transarterial chemoembolization (TACE) in HCC. Materials Methods This multi-institutional retrospective study included consecutive treatment-naive adult HCC who underwent either or TACE...
Abstract Introduction Ultrasound is important in heart diagnostics, yet implementing effective cardiac ultrasound requires training. While current strategies incorporate digital learning and simulators, the effectiveness of these simulators for remains uncertain. This study evaluates simulator-based versus human-based training Focused Assessed with Transthoracic Echocardiography (FATE). Materials methods single-centre, prospective, randomised controlled was conducted during an...
The BCLC-staging system is used to facilitate treatment decisions in patients with hepatocellular carcinoma (HCC). Owing the observed clinical heterogeneity of intermediate stage BCLC-B, a subclassification was proposed taking Child-Pugh score and extended criteria for transplantation into account. Analysis prognostic significance BCLC-B European cohort HCC patients.Eight hundred eighty four consecutive were retrospectively analysed. Patients grouped according subclassification. Baseline...
Abstract Background & Aims Portal vein tumour thrombosis (PVTT) has a significant impact on the prognosis of patients with hepatocellular carcinoma (HCC). The degree PVTT varies from sub‐/segmental invasion to complete occlusion main trunk. Aim this study was evaluate whether correlates prognosis. Methods A total 1317 HCC treated at our tertiary referral centre between January 2005 and December 2016 were included. diagnosed by contrast‐enhanced computed tomography or magnetic resonance...
PURPOSE Image analysis is one of the most promising applications artificial intelligence (AI) in health care, potentially improving prediction, diagnosis, and treatment diseases. Although scientific advances this area critically depend on accessibility large-volume high-quality data, sharing data between institutions faces various ethical legal constraints as well organizational technical obstacles. METHODS The Joint Imaging Platform (JIP) German Cancer Consortium (DKTK) addresses these...
The novel CRP-albumin-lymphocyte (CALLY) index is an improved immunonutritive scoring system, based on serum C-reactive protein (CRP), albumin, and the lymphocyte count. It has shown promise as a prognostic for patients with hepatocellular carcinoma (HCC) undergoing resections. This study evaluated ability of CALLY HCC transarterial chemoembolization (TACE). We retrospectively identified 280 treatment-naïve that underwent initial TACE at our institution, between 2010 2020. compared to...