A5101721378- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
- Systemic Lupus Erythematosus Research
- Liver physiology and pathology
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Metabolism, Diabetes, and Cancer
- Genetic Syndromes and Imprinting
- Neonatal Respiratory Health Research
- Heme Oxygenase-1 and Carbon Monoxide
- Lipid metabolism and disorders
- Pancreatitis Pathology and Treatment
- Peroxisome Proliferator-Activated Receptors
- Liver Disease and Transplantation
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition and Health in Aging
- Bone health and osteoporosis research
- Nitric Oxide and Endothelin Effects
Wenzhou Medical University
2014-2025
Guangdong Medical College
2025
First Affiliated Hospital of Wenzhou Medical University
2023-2025
Shanghai Electric (China)
2025
Shenzhen University Health Science Center
2025
Innovation Team (China)
2025
Northwest A&F University
2025
Fujian Medical University
2025
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Background— Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism insulin sensitivity. It acts as key downstream target of both peroxisome proliferator-activated receptor α γ, the agonists which have been used for lowering sensitization, respectively. However, role FGF21 in cardiovascular system remains elusive. Methods Results— The roles atherosclerosis were investigated by evaluating impact deficiency replenishment recombinant...
Exercise promotes adipose remodeling and improves obesity-induced metabolic disorders through mechanisms that remain obscure. Here, we identify the FGF21 signaling in tissues as an obligatory molecular transducer of exercise conferring its benefits mice. Long-term high fat diet-fed obese mice exhibit compromised effects exogenous on alleviation hyperglycemia, hyperinsulinemia, hyperlipidemia, accompanied with markedly reduced expression FGF receptor-1 (FGFR1) β-Klotho (KLB) tissues. These...
Fibroblast growth factor 21 (FGF-21) is a metabolic regulator with multiple beneficial effects on glucose homeostasis and lipid metabolism in animal models. The relationship between plasma levels of FGF-21 coronary heart disease (CHD) unknown.This study aimed to investigate the correlation serum patients disease. We performed logistic regression analysis relation CHD without diabetes hypertension. This was conducted Departments Endocrinology Cardiovascular Diseases at two University...
Background Fibroblast growth factor 21 (FGF21) is a hepatic hormone involved in the regulation of lipid and carbohydrate metabolism. This study aims to test hypothesis that elevated FGF21 concentrations are associated with change renal function presence left ventricular hypertrophy (LVH) different stages chronic kidney disease (CKD) progression. Methodology/Principal Findings 240 subjects including 200 CKD patients (146 outpatients 54 long-term hemodialytic patients) 40 healthy control were...
•This is the first phase III trial comparing SCRT followed by immunochemotherapy to LCRT chemotherapy in LARC.•Neoadjuvant CAPOX and camrelizumab significantly improved pCR versus neoadjuvant CAPOX.•Neoadjuvant demonstrated promising efficacy LARC patients with pMMR/MSS.•The treatment arm provides opportunity for organ preservation a watch-and-wait strategy.•No unexpected toxicities were observed, safety profile of was manageable. BackgroundNeoadjuvant short-course radiotherapy (SCRT) (a...
Vps34, a class III PtdIns3 lipid kinase involved in the control of both autophagic and endocytic systems, has been studied extensively numerous fundamental cellular processes. Accumulating evidence indicates that Vps34 may also contribute to development progression human cancers. However, mechanism tumorigenesis remains elusive. Here, we report an unanticipated role activation p62 for cancer development. We identified is transcriptional activator through competition Nrf2 (nuclear factor...
Abstract Liver injury can lead to different hepatic diseases, which are the mainly causes of high global mortality and morbidity. Autophagy Sirtuin type 1 (SIRT1) have been shown protective effects in response liver injury. Previous studies showed that Fibroblast growth factor 21 (FGF21) could alleviate acute (ALI), but mechanism remains unclear. Here, we verified relationship among FGF21, autophagy SIRT1 carbon tetrachloride (CCl 4 )‐induced ALI. We established CCl ‐induced ALI models...
Fibroblast growth factor 21 (FGF21), an endocrine predominantly secreted from liver, possesses multiple beneficial effect on energy metabolism and insulin sensitivity in animals. This study aimed to investigate the acute change of serum FGF21 response glucose challenge humans.A 75-g oral tolerance test was performed among 20 healthy subjects, 18 with impaired (IGT) type 2 diabetes mellitus (T2DM). Blood samples were collected for measurement other biochemical parameters. The associations...
Abstract Fibroblast growth factor 21 ( FGF 21) is important in glucose, lipid homeostasis and insulin sensitivity. However, it remains unknown whether involved expression secretion that are dysregulated type 2 diabetes mellitus (T2 DM ). In this study, we found was down‐regulated pancreatic islets of db/db mice, a mouse model T2 , along with decreased expression, suggesting the possible involvement maintaining islet β‐cell function. Importantly, knockout exacerbated palmitate‐induced failure...
Ginsenoside Rg2 (G-Rg2) in the rhizome of Panax ginseng can modify lipid accumulation, oxidative stress, and apoptosis liver induced by a high-fat diet. This research adds to this assessing potential antifibrosis effect G-Rg2 (including possible mechanisms). significantly improved pathological changes tissue choline-deficient, l-amino acid-defined, diet (CDAHFD), it inhibited serum transaminase, plasma lipopolysaccharide, hydroxyproline levels; TGF-β1, α-SMA, COL1A1 expression, activated...
Background Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP superfamily, possesses anti-inflammatory and anti-diabetic effects in mice. However, clinical relevance CTRP1 has been seldom explored. The current study aimed to investigate association circulating type 2 diabetes mellitus (T2DM) Chinese population. Design Methods Serum adiponectin levels 96 T2DM patients 85 healthy subjects were determined by ELISA, their associations with adiposity, glucose lipid profiles...
The aim of the present study is to explore molecular mechanism fibroblast growth factor 21 (FGF21) in protecting against diabetic cardiomyopathy (DCM). Streptozotocin/high-fat diet (STZ/HFD) was used induced diabetes FGF21-deficient mice and their wild-type littermates, followed by evaluation difference DCM between two genotypes. Primary cultured cardiomyocytes were also potential FGF21 protection high glucose (HG)-induced cardiomyocyte injury. STZ/HFD-induced exacerbated knockout mice,...
The liver, as the largest metabolic and detoxification organ in mammals, metabolizes approximately 80-90% of drugs. However, drug-induced liver injury (DILI) is common driven by factors such individual variability, differences metabolism, improper drug use. Mesenchymal stem cells (MSCs), with their self-renewal multipotent differentiation capabilities, offer therapeutic potential, but face challenges limited proliferation increased apoptosis during vitro expansion. Although MSCs exhibit low...
ABSTRACT Background A minimally invasive spherical osteotomy assistant system (MISOS) based on a multi‐axis surgical robot was designed to improve the control and precision of manual osteotomy. Methods Based human sawbone models, feasibility MISOS verified by comparing centre deviation section curvature acetabulum, femur, tibia. Results Compared with freehand osteotomy, demonstrated superior for acetabulum (1.48 ± 0.93 vs. 11.15 3.97 mm), femur (3.12 0.75 8.81 3.04 tibia (1.91 0.84 7.33 1.53...
ABSTRACT Exogenous fibroblast growth factor (FGF) 23 is closely associated with atrial fibrillation (AF) and able to alter the cardiac electrophysiological activity by increasing intracellular calcium. While its arrhythmogenic mechanism remains unclear, this study aims investigate effects of FGF23 on calcium in cells underlying mechanism. The incidence AF was significantly decreased f/f MyHC Cre/+ mice compared Cre mice. A significant increase triggering (TA), L‐type currents (I Ca,L )...
Sonic hedgehog (Shh) signaling controls many aspects of human development, regulates cell growth and differentiation in adult tissues, is activated a number malignancies. Rheumatoid arthritis (RA) characterized by chronic synovitis pannus formation associated with activation fibroblast-like synoviocytes (FLS). We investigated whether Shh plays role the proliferation FLS RA. Expression related components (Shh, Ptch1, Smo, Gli1) RA synovial tissues was examined immunohistochemistry (IHC) IHC,...