A5101726698- Liver Disease Diagnosis and Treatment
- Kruppel-like factors research
- Esophageal and GI Pathology
- IL-33, ST2, and ILC Pathways
- Drug-Induced Hepatotoxicity and Protection
- Eosinophilic Esophagitis
- Adipokines, Inflammation, and Metabolic Diseases
- Microbial Metabolites in Food Biotechnology
- Pediatric health and respiratory diseases
- Liver Disease and Transplantation
- Dermatology and Skin Diseases
- Neurological and metabolic disorders
- Liver physiology and pathology
- Wound Healing and Treatments
- Preterm Birth and Chorioamnionitis
- interferon and immune responses
- Lipid metabolism and disorders
- Diabetic Foot Ulcer Assessment and Management
- Alcoholism and Thiamine Deficiency
- Traditional Chinese Medicine Analysis
- Metabolism, Diabetes, and Cancer
- Probiotics and Fermented Foods
- Epilepsy research and treatment
- Monoclonal and Polyclonal Antibodies Research
- Diabetes Management and Education
The First People's Hospital of Xiaoshan District, Hangzhou
2023
Wenzhou Medical University
2014-2023
Hangzhou Medical College
2023
Zhejiang Provincial People's Hospital
2023
Children's Hospital of Philadelphia
2018-2019
University of Pennsylvania
2018
Philadelphia University
2018
Hangzhou Hospital of Traditional Chinese Medicine
2012
Prior investigations have primarily focused on the impact of L-arabinose gut microbiota, with limited exploration into dual mechanisms microbiota and metabolism both in vivo vitro. Thus, this study aimed to elucidate anti-inflammatory effects 5 % under different diet mice. Additionally, a colon simulation system (CDMN) utilizing 1.72 (w/v) lumen mucus layers, provide further insights underlying mechanisms. The results revealed that significantly altered microbiome structure, particularly...
Abstract Interleukin-1β (IL-1β) is a key mediator of innate immunity against pathogen infections. However, dysregulated IL-1β activity associated with various autoinflammatory, autoimmune, degenerative, atherosclerotic diseases, and cancers. Biologic drugs that neutralize excess activity, such as canakinumab, have been effective in treating IL-1β-mediated diseases. This article reports the discovery development novel humanized anti-IL-1β antibody, designated TAVO103A, which exhibited potent...
Background Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP superfamily, possesses anti-inflammatory and anti-diabetic effects in mice. However, clinical relevance CTRP1 has been seldom explored. The current study aimed to investigate association circulating type 2 diabetes mellitus (T2DM) Chinese population. Design Methods Serum adiponectin levels 96 T2DM patients 85 healthy subjects were determined by ELISA, their associations with adiposity, glucose lipid profiles...
The aim of the present study is to explore molecular mechanism fibroblast growth factor 21 (FGF21) in protecting against diabetic cardiomyopathy (DCM). Streptozotocin/high-fat diet (STZ/HFD) was used induced diabetes FGF21-deficient mice and their wild-type littermates, followed by evaluation difference DCM between two genotypes. Primary cultured cardiomyocytes were also potential FGF21 protection high glucose (HG)-induced cardiomyocyte injury. STZ/HFD-induced exacerbated knockout mice,...
Abstract Background Germline‐encoded innate immune pattern recognition receptors (PRR) are expressed at epithelial surfaces and modulate defenses. Evidence suggests that stimulation of the Toll‐like receptor (TLR) family PRR may regulate barrier integrity by upregulating tight junction (TJ) complex protein expression, but it is not known whether this mechanism utilized in esophageal cells. TJ proteins maintain intact function dysregulated atopic disorders including eosinophilic esophagitis....
Chemokine C-X-C ligand 16 (CXCL16), a single-pass Type I membrane protein belonging to the CXC chemokine family, is related inflammatory response in liver injury. In present study, we investigated pathophysiological role of CXCL16, unique membrane-bound chemokine, acetaminophen (APAP)-induced hepatotoxicity mice. Mice were injected with APAP, and blood tissue samples harvested at different time points. The serum high-mobility group box 1 CXCL16 levels quantified by sandwich immunoassays....
Abstract Background and Aims This study aimed to investigate the relationship between circulating soluble C‐X‐C chemokine ligand 16 (CXCL16) levels clinical characteristics of gallstone. Methods 93 subjects including 53 with gallstone, 25 nonalcoholic fatty liver disease (NAFLD), 40 control were recruited. All gallstone underwent ultrasounds confirm patients. Serum CXCL16 other biochemical parameters in all obtained based on standard examination methods. Liver tissues from patients...
Introduction Thymic stromal lymphopoietin (TSLP) is a master regulator of allergic inflammation against pathogens at barrier surfaces the lung, skin, and gut. However, aberrant TSLP activity implicated in various allergic, chronic autoimmune diseases cancers. Biologics drugs neutralizing excess represented by tezepelumab have been approved for severe asthma are being evaluated treatments other TSLP-mediated diseases. Methods results In this study, we discovered characterized novel humanized...