A5004975012- Fibroblast Growth Factor Research
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Kruppel-like factors research
- Genomics, phytochemicals, and oxidative stress
- PI3K/AKT/mTOR signaling in cancer
- Phytochemical compounds biological activities
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Periodontal Regeneration and Treatments
- Plant Molecular Biology Research
- Berberine and alkaloids research
- Wound Healing and Treatments
- Corneal Surgery and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Genetic Syndromes and Imprinting
- Pancreatic function and diabetes
- Medicinal Plant Pharmacodynamics Research
- Wnt/β-catenin signaling in development and cancer
First Affiliated Hospital of Guangdong Pharmaceutical University
2018-2025
Jinan University
2016-2025
The First People's Hospital of Shunde
2025
The Affiliated Shunde Hospital of Jinan University
2024
Karolinska Institutet
2023
Guangdong Pharmaceutical University
2018-2022
First Affiliated Hospital of Jinan University
2015-2020
Wenzhou Medical University
2007-2019
Southern Medical University
2017
Nanfang Hospital
2017
Background— Altered composition of the gut microbiota is involved in both onset and progression obesity diabetes mellitus. However, link between obesity-related cardiovascular complications has not been explored. The present study was designed to investigate role Akkermansia muciniphila , a mucin-degrading bacterium with beneficial effects on metabolism, pathogenesis atherosclerosis apolipoprotein E–deficient ( Apoe −/− ) mice. Methods Results— mice normal chow diet or Western were treated A...
EF24, a synthetic analogue of curcumin, was developed as an anti-tumor compound to induce apoptosis, inhibit proliferation and metastasis in various cancers. However, whether EF24 induces ferroptosis osteosarcoma cells or not, its underlying mechanism remains largely elusive. After combining with without other compounds treatments, mRNA expression profiles were proceeded by RNA sequencing. Cytotoxicity measured cell counting kit-8 assay. Cell death quantified flow cytometer. Gene real-time...
Fibroblast growth factor 21 (FGF-21) is a metabolic regulator with multiple beneficial effects on glucose homeostasis and lipid metabolism in animal models. The relationship between plasma levels of FGF-21 coronary heart disease (CHD) unknown.This study aimed to investigate the correlation serum patients disease. We performed logistic regression analysis relation CHD without diabetes hypertension. This was conducted Departments Endocrinology Cardiovascular Diseases at two University...
Background Fibroblast growth factor 21 (FGF21) is a hepatic hormone involved in the regulation of lipid and carbohydrate metabolism. This study aims to test hypothesis that elevated FGF21 concentrations are associated with change renal function presence left ventricular hypertrophy (LVH) different stages chronic kidney disease (CKD) progression. Methodology/Principal Findings 240 subjects including 200 CKD patients (146 outpatients 54 long-term hemodialytic patients) 40 healthy control were...
To investigate the structure of silk and its degradation properties, we have monitored using scanning electron microscopy frozen sections. Raw degummed raw were immersed in four types solutions for 156 d to observe their properties. The subcutaneous implants rats removed after 7, 14, 56, 84, 129, 145 sectioning subsequent staining with hematoxylin eosin (H.E.), DAPI, Beta-actin Collagen I immunofluorescence staining. vitro weight loss ratio water, PBS, DMEM containing 10% FBS (F-DMEM) were,...
Background and Purpose Increasing energy expenditure through adipocyte thermogenesis is generally accepted as a promising strategy to mitigate obesity its related diseases. However, few clinically effective safe agents are known promote thermogenesis. In this study, 20 traditional Chinese herbal medicines were screened examine whether they induced Experimental Approach The effects of or components isolated from extracts A. membranaceus, on analysed by assessing expression uncoupling protein...
Fibroblast growth factor 21 (FGF21), an endocrine predominantly secreted from liver, possesses multiple beneficial effect on energy metabolism and insulin sensitivity in animals. This study aimed to investigate the acute change of serum FGF21 response glucose challenge humans.A 75-g oral tolerance test was performed among 20 healthy subjects, 18 with impaired (IGT) type 2 diabetes mellitus (T2DM). Blood samples were collected for measurement other biochemical parameters. The associations...
Hepatosteatosis, defined as excessive intrahepatic lipid accumulation, represents the first step of nonalcoholic fatty liver disease (NAFLD). When combined with additional cellular stress, this benign status progresses to local and systemic pathological conditions such steatohepatitis insulin resistance. However, molecular events directly caused by hepatic buildup, in terms its impact on biology peripheral organs, remain unclear. Carnitine palmitoyltransferase 1A (CPT1A) is rate-limiting...
Recent studies have identified pleiotropic roles of methyltransferase-like 3 (METTL3) in tumor progression. However, the METTL3 esophageal squamous cell carcinoma (ESCC) are still unclear. Here, we investigated function and mechanism ESCC tumorigenesis. We reported that higher expression was found tissues markedly associated with depth invasion poor prognosis. Loss- gain-of showed promoted migration cells vitro . Integrated methylated RNA immunoprecipitation sequencing (MeRIP-Seq) (RNA-Seq)...
Cervical cancer (CC) stem cell-like cells (CCSLCs), defined by the capacity of differentiation and self-renewal proliferation, play a significant role in progression CC. However, molecular mechanisms regulating their are poorly understood. Therefore, elucidation epigenetic that drive cell will enhance our ability to improve effectiveness targeted therapies for cells. To explore how DNA methyltransferase 1 (DNMT1)/miR-342-3p/Forkhead box M1 (FoxM1), which have been shown abnormal expression...
The development of non-invasive ocular drug delivery systems is practical importance in the treatment retinal disease. In this study, we evaluated efficacy transactivator transcription protein transduction domain (TAT-PTD, TAT(49-57)) as a vehicle to deliver acidic FGF (aFGF) retina rats. TAT-conjugated aFGF-His (TAT-aFGF-His) exhibited efficient penetration into following topical administration surface. Immunochemical staining with anti-His revealed that TAT-aFGF-His proteins were readily...
Fibroblast growth factor receptors (FGFRs) have been implicated in the malignant transformation and chemoresistance of epithelial ovarian cancer; however, underlying molecular mechanisms are poorly understood. Increased sialyltransferase activity that enhances protein sialylation is an important post‑translational process promoting cancer progression malignancy. In present study, α2,6‑sialyltransferase (ST6Gal‑I) overexpression or knockdown cell lines were developed, FGFR1 was examined to...