A5100662155- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Salmonella and Campylobacter epidemiology
- Rabies epidemiology and control
- Functional Brain Connectivity Studies
- Connective Tissue Growth Factor Research
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Phagocytosis and Immune Regulation
- Nerve injury and regeneration
- RNA modifications and cancer
- Workplace Health and Well-being
- Retinoids in leukemia and cellular processes
- Advanced biosensing and bioanalysis techniques
- Microbial Natural Products and Biosynthesis
- Medicinal Plants and Bioactive Compounds
- NF-κB Signaling Pathways
- Yersinia bacterium, plague, ectoparasites research
- Genetic Associations and Epidemiology
- Aquaculture Nutrition and Growth
- Antimicrobial Peptides and Activities
University of Maryland, Baltimore
2009-2024
Shanghai Municipal Center For Disease Control Prevention
2003-2024
Soochow University
2015-2023
First Affiliated Hospital of Soochow University
2015-2023
Affiliated Hospital of Nantong University
2020-2023
Nantong University
2020-2023
China Tobacco
2022
Tianjin Medical University Cancer Institute and Hospital
2019-2021
Zhongda Hospital Southeast University
2015-2021
Binzhou People's Hospital
2021
Abstract Understanding the roles of noncoding RNAs (ncRNA) in tumorigenesis and metastasis would establish novel avenues to identify diagnostic therapeutic targets. Here, we aimed hepatocellular carcinoma (HCC)–specific ncRNA investigate their hepatocarcinogenesis metastasis. RNA-seq xenografts generated by lung identified long RNA small nucleolar host gene 10 (SNHG10) its homolog SCARNA13 as drivers for development HCC. SNHG10 expression positively correlated with 64 HCC cases, high or was...
Cell-penetrating peptides provide a unique platform to create new generation of cancer therapeutics with enhanced efficacy and diminished toxicity. In our study, expression toll-like receptor 2 (TLR2) was observed in acute myeloid leukemia (AML) cells. Screening phage display peptide library using Biopanning Rapid Analysis Selective Interactive Ligands (BRASIL) identified TLR2-binding motif, Pep2. We show that the motif targeted penetrated into cells TLR2-dependent manner. Moreover,...
Sustained attention abnormality in schizophrenia is usually refractory to available treatment. Nicotine can transiently improve sustained patients, although its neural mechanisms are unknown. Understanding the basis of this effect may lead new treatment strategies for cognitive deficit. Twenty patients and 24 healthy comparison smokers participated a double-blind, placebo-controlled, crossover, randomized functional magnetic resonance imaging study comparing nicotine vs placebo patch on...
Ammonia is one of the most common toxicological environment factors affecting shrimp health. Although ammonia tolerance in closely related to successful industrial production, few genetic studies this trait are available.In study, we constructed a high-density map Pacific white (Litopenaeus vannamei) using specific length amplified fragment sequencing (SLAF-seq). The contained 17,338 polymorphic markers spanning 44 linkage groups, with total distance 6360.12 centimorgans (cM) and an average...
Abstract Background Endothelial‐to‐mesenchymal transition (EndMT) is a common pathophysiology in valvular calcification (VC) among non‐chronic kidney disease (CKD) patients. However, few studies were investigated CKD‐induced VC. Parathyroid hormone (PTH) was considered to be an important component of EndMT cardiovascular diseases. Therefore, determining whether PTH could induce and elucidating corresponding mechanism involved further study. Methods Performing 5/6 nephrectomy with high...
CircRNAs are associated with adriamycin (ADM) resistance in triple‑negative breast cancer (TNBC), but the mechanism is unknown. Reverse transcription‑quantitative PCR was applied to quantify circular RNA (circRNA)_0044556, microRNA (miR)‑145 and NRAS proto‑oncogene, GTPase (NRAS) TNBC tissues cells or without ADM treatment. Following treatment, effects of circRNA_0044556 on viability, resistance, apoptosis migration were investigated by cell function experiments (Cell Counting Kit‑8, flow...
This research was to investigate the role of miR-223-3p targeting epithelial cell transforming sequence 2 oncogene (ECT2) in activity, apoptosis, invasion and migration MDA-MB-468 breast cancer (BC) cells.The human BC lines were used for experiment. They divided into six groups: blank group (no plasmid transfection), NC (negative control, transfected empty plasmid), mimic (transfected inhibitor si-ECT2 si ECT2 plasmid) mimic+oe-ECT2 with plasmid).Compared group, mRNA protein expression Bax...
Aspernolide A, a butyrolactone secondary metabolite, was purified from the endophytic fungus Cladosporium cladosporioides derived roots of Camptotheca acuminata Decne. In this study, antitumor activity and mechanisms aspernolide A on human laryngeal cancer Hep-2 TU212 cells were studied by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, morphological observation Western blotting. The results showed that significantly inhibited proliferation in dose- time-dependent...
Aberrant expression of long non-coding RNAs (lncRNAs) is closely associated with development and prognosis human cancers. LncRNA SNHG16 reportedly involved in cancer; however, its roles multiple myeloma (MM) remain unclear.In this study, we investigated the function molecular mechanisms MM. MM cells were transfected si-SNHG16 or si-NC. levels was measured by qRT-PCR. Cell proliferation monitored using MTS. Flow cytometry assay performed to measure cell cycle apoptosis. Luciferase reporter...
Background/Aims: Ganoderic acid A (GAA) isolated from Ganoderma lucidum, shows various benefit activities, such as anti-tumor activity, anti-HIV activity and hepatoprotective activity. However, the potential effects of GAA on hypoxia-induced injury cardiomyocytes are still unclear. In this study, we aimed to reveal hypoxic-induced H9c2 cell injury, well underlying molecular mechanisms. Methods: Rat were cultured in hypoxia condition with different doses GAA. Cell viability apoptosis detected...
Previous studies have shown that high glucose (HG) induced endothelial cell (EC) damage via a phenotypic transition of EC. There is increasing evidence suggesting the role inflammatory cytokines in mediated HG-induced EC damage. However, little known about potential interleukin-1β (IL-1β) process. The aim present study was to investigate whether IL-1β HG–induced human aortic cells (HAECs) and determine possible underlying mechanism. Primary HAECs were exposed normal (NG, 5.5 nM), (HG,30 (10...
Abstract Background The true incidence of acute gastrointestinal illness in China is underrecognized by surveillance systems. aims this study were to estimate the and prevalence self-reported AGI community China, investigate sociodemographic epidemiological determinants AGI. Methods We conducted a 12-months cross-sectional population-based survey eight provinces during 2014–2015. determined (AGI) total permanent resident population according census 2010. random multilevel sample was...