A5039464004- Probiotics and Fermented Foods
- Gut microbiota and health
- Fungal Biology and Applications
- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Microbial Metabolites in Food Biotechnology
- Medicinal Plants and Bioactive Compounds
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Advanced biosensing and bioanalysis techniques
- Phytochemical compounds biological activities
- Ubiquitin and proteasome pathways
- Angiogenesis and VEGF in Cancer
- Nuclear Structure and Function
- Animal Virus Infections Studies
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- Microtubule and mitosis dynamics
- Polysaccharides and Plant Cell Walls
- Pluripotent Stem Cells Research
- Advanced Drug Delivery Systems
- Endometriosis Research and Treatment
Wuhan Third Hospital
2025
Tongren Hospital
2025
China Medical University
2013-2024
Huangshi Central Hospital
2015-2022
Kaohsiung Medical University
2017-2020
National Health Research Institutes
2013-2019
Kaohsiung Medical University Chung-Ho Memorial Hospital
2017
National Taiwan University
2017
China Medical University Hospital
2016
Huazhong University of Science and Technology
2014
Antidepressant-like effects of ethanolic extract Hericium erinaceus (HE) mycelium enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) were examined. HE at 100, 200 or 400 mg/kg body weight/day was orally given to for four weeks. After two weeks administration, all except the control group went through with 14 days RS protocol. Stressed exhibited various behavioral alterations, such as extending immobility time tail suspension test (TST) and forced swimming...
Osteoporosis, an imbalance in the bone-forming process mediated by osteoblasts and bone-resorbing function osteoclasts, is a bone degenerative disease prevalent among aged population. Due to deleterious side effects of currently available medications, probiotics as potential treatment osteoporosis appealing approach. Hence, this study aims evaluate beneficial two novel Lactobacilli strain on health ovariectomized (OVX) induced osteoporotic mice model its underlying mechanisms. Forty-five...
ABSTRACT Hutchinson-Gilford progeria syndrome (HGPS) is a human progeroid disease caused by point mutation on the LMNA gene. We reported previously that accumulation of nuclear envelope protein SUN1 contributes to HGPS aberrancies. However, mechanism which interactions between mutant lamin A (also known as progerin or LAΔ50) and produce cellular phenotypes requires further elucidation. Using light electron microscopy, this study demonstrated progerin-elicited structural changes in...
To improve the targeting delivery efficiency of anticancer drug to tumor sites, a new strategy combining cell-permeable peptide (CPP) and ultrasound was reported in this article. In study, we devised tested for functional payload cells by loading CPP-camptothecin conjugate (CPP-CPT) into nanobubble (CPP-CPT NB). Here, CPP existing conjugation form CPT hidden cloak penetration activity CPP. Meanwhile, local utilized achieve specific CPP-CPT cells. The mean particle size prepared NB ∼200 nm,...
(1) Background: An age-related cognitive decline is commonly affecting the life of elderly with symptoms involved in progressive impairments to memory and learning. It has been proposed that probiotics could modulate neurological disorders via gut-brain axis. (2) Methods: To investigate anti-aging effect probiotic
The aim of this study was to develop and evaluate an extended-release (ER) push-pull osmotic pump (PPOP) tablet for phencynonate HCl (PCN), which could release the drug at zero-order profile a duration 24 h. core tablets were designed as bi-layered, primarily composed sodium chloride polyethylene oxide (PEO). central composite design (CCD) within response surface methodology (RSM) used optimize formulation. An optimized PCN-PPOP formulation achieved with following values key factors: 10 mg...
Adriamycin (ADM)-encapsulated thermosensitive liposomes (ts-lip-ADM) and common (lip-ADM) were developed evaluated. The encapsulation efficiency of the two above 99%, average sizes about 120 nm. Temperature-dependent drug release from loaded in vitro was investigated: more than 90% ADM released ts-lip-ADM within 30 min at 42°C, while less 3% lip-ADM 42°C beyond min. An model blood brain barrier (BBB) established evaluated by permeability transendothelial electrical resistance (TEER)....
Deep sea water (DSW), originally pumped from the Pacific Rim off coast of Hualien County (Taiwan), and its mineral constituents, were concentrated by a low-temperature vacuum evaporation system to produce hardness approximately 400,000 mg/L seawater concentrate. The primary composition this concentrate was ionic magnesium (Mg2+), which 96,000 mg/L. Referring human recommended daily allowance (RDA) magnesium, we diluted three different dosages: 0.1 × DSW (equivalent 3.75 mg Mg2+/kg DSW); 1...
The overexpression of Aurora kinases in multiple tumors makes these appealing targets for the development anticancer therapies. This study identified two small molecules with a furanopyrimidine core, IBPR001 and IBPR002, that target induce DFG conformation change at ATP site A. Our results demonstrate high potency IBPR compounds reducing tumorigenesis colorectal cancer xenograft model athymic nude mice. Human hepatoma up-regulated protein (HURP) is substrate kinase A, which plays crucial...
Abstract Reprogramming of cancer cells into induced pluripotent stem (iPSCs) is a compelling idea for inhibiting oncogenesis, especially through modulation homeobox proteins in this reprogramming process. We examined the role various long noncoding RNAs (lncRNAs)-homeobox protein HOXA13 axis on switching oncogenic function bone morphogenetic 7 (BMP7), which significantly lost gastric cell derived iPS-like (iPSLCs). BMP7 promoter activation occurred corecruitment HOXA13, mixed-lineage...
To specifically deliver cytotoxic drug to tumor cells and enhance cellular uptake is the key for effective cancer therapy. In this paper, we described a novel targeting system, which designed combine features of biological (cell-penetrating peptides, CPPs) physical (magnetic) use in magnetic hyperthermia-triggered release. A doxorubicin-CPPs conjugate (DOX-CPPs) was loaded into thermosensitive liposomes (TSMLs) (DOX-CPPs/TSMLs), vitro DOX-CPPs release activity, anti-proliferation effect,...
Acute kidney injury (AKI) describes a sudden loss of function and is associated with high mortality.
Breast cancer frequently metastasizes to bone, where it leads poor clinical prognosis. Due the peculiarity of bone microstructure, uptake drugs often happens at non-targeted sites, which produces a similar cytotoxicity in both cancerous and healthy cells. In this study, rational strategy was implemented take advantage combination an octapeptide with eight repeating sequences aspartate (Asp8) folate create more selective efficient drug delivery system target cells tissue. Asp8 were conjugated...
A new drug-targeting system for CD13+ tumors has been developed, based on ultrasound-sensitive nanobubbles (NBs) and cell-permeable peptides (CPPs). Here, the CPP-doxorubicin conjugate (CPP-DOX) was entrapped in asparagine–glycine–arginine (NGR) peptide modified NB (CPP-DOX/NGR-NB) penetration of CPP-DOX temporally masked; local ultrasound stimulation could trigger release from activate its penetration. The CPP-DOX/NGR-NBs had particle sizes about 200 nm drug entrapment efficiency larger...