A5004857890- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Asymmetric Hydrogenation and Catalysis
- Axial and Atropisomeric Chirality Synthesis
- Advanced Synthetic Organic Chemistry
- Oxidative Organic Chemistry Reactions
- Microtubule and mitosis dynamics
- Marine Sponges and Natural Products
- Bioactive Compounds and Antitumor Agents
- Plant nutrient uptake and metabolism
- Photosynthetic Processes and Mechanisms
Rutgers, The State University of New Jersey
1997-2015
Abstract A readily available chiral Brønsted acid was identified as an efficient catalyst for intramolecular Povarov reactions. Polycyclic amines containing three contiguous stereogenic centers were obtained with excellent stereocontrol in a single step from secondary anilines and aldehydes possessing pendent dienophile. These transformations constitute the first examples of catalytic enantioselective aza‐Diels–Alder
The overexpression of Aurora kinases in multiple tumors makes these appealing targets for the development anticancer therapies. This study identified two small molecules with a furanopyrimidine core, IBPR001 and IBPR002, that target induce DFG conformation change at ATP site A. Our results demonstrate high potency IBPR compounds reducing tumorigenesis colorectal cancer xenograft model athymic nude mice. Human hepatoma up-regulated protein (HURP) is substrate kinase A, which plays crucial...
Abstract A readily available chiral Brønsted acid was identified as an efficient catalyst for intramolecular Povarov reactions. Polycyclic amines containing three contiguous stereogenic centers were obtained with excellent stereocontrol in a single step from secondary anilines and aldehydes possessing pendent dienophile. These transformations constitute the first examples of catalytic enantioselective aza‐Diels–Alder
Abstract Highly annulated heterocycles are obtained via intramolecular Povarov reaction promoted by a readily available chiral Broensted acid catalyst.
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