A5023435796- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Bone fractures and treatments
- Spine and Intervertebral Disc Pathology
- Reconstructive Surgery and Microvascular Techniques
- Musculoskeletal synovial abnormalities and treatments
- Titanium Alloys Microstructure and Properties
- Bone and Joint Diseases
- Management of metastatic bone disease
- Spinal Fractures and Fixation Techniques
- Magnesium Alloys: Properties and Applications
- Dental Implant Techniques and Outcomes
- Total Knee Arthroplasty Outcomes
- Hip disorders and treatments
- Oral and Maxillofacial Pathology
- Foot and Ankle Surgery
- Cancer-related molecular mechanisms research
- Polymer Surface Interaction Studies
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Surgery and Rehabilitation
- Bone health and treatments
- Radiomics and Machine Learning in Medical Imaging
Air Force Medical University
2016-2025
Tang Du Hospital
2024
Army Medical University
2023
Nanjing University of Science and Technology
2023
Xijing Hospital
2012-2021
China XD Group (China)
2016-2020
First Affiliated Hospital of Gannan Medical University
2020
Zhengzhou University
2019
Shihezi University
2017
Zhangqiu City People's Hospital
2016
Osteosarcoma is the most common primary bone tumor in children and adolescents. Unfortunately, osteosarcoma treatments often fail due to development of chemoresistance, which underlying molecular mechanisms still remain unclear. In this study, we demonstrated that HSP90AA1 gene responsible for drug resistance through an autophagy-related mechanism.shRNAs were transfected into cells knockdown gene. Stable overexpressing cell lines obtained by lentivirus infection. mRNA protein expressions...
Titanium alloys with various porous structures can be fabricated by advanced additive manufacturing techniques, which are attractive for use as scaffolds bone defect repair. However, modification of the scaffold surfaces, particularly inner is critical to improve osteointegration these scaffolds. In this study, a biomimetic approach was employed construct polydopamine-assisted hydroxyapatite coating (HA/pDA) onto Ti6Al4V electron beam melting method. The surface characterized field emission...
Polyetheretherketone (PEEK) has been an alternative material for titanium in bone defect repair, but its clinical application is limited by poor osseointegration. In this study, a porous structural design and activated surface modification were used to enhance the osseointegration capacity of PEEK materials. Porous scaffolds manufactured via fused deposition modeling polydopamine (PDA) coating chelated with magnesium ions (Mg2+) was utilized on surface. After modification, hydrophilicity...
Abstract Interbody fusion cages made of poly‐ether‐ether‐ketone ( PEEK ) have been widely used in clinics for spinal disorders treatment; however, they do not integrate well with surrounding bone tissue. T i‐6 A l‐4 V i) has demonstrated greater osteoconductivity than , but the traditional i cage is generally limited by its much elastic modulus (110 GPa natural (0.05–30 ). In this study, we developed a porous using electron beam melting EBM technique to reduce and compared efficacy...
Abstract The drawbacks of traditional bone-defect treatments have prompted the exploration bone tissue engineering. This study aimed to explore suitable β-tricalcium phosphate (β-TCP) granules for regeneration and identify an efficient method establish β-TCP-based osteo-regenerators. β-TCP with diameters 1 mm 1–2.5 were evaluated in vitro . superior osteogenic properties used vivo bioreactors, referred as osteo-regenerators, which fabricated using two different methods. Improved...
The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application. Early angiogenesis is important for survival. It necessary to develop a multifunctional surface on with both osteogenic angiogenic properties. In this study, biofunctional magnesium coating deposited Ti6Al4V scaffold. For analysis, in vitro studies reveal that magnesium-coated co-culture MC3T3-E1 cells can improve cell proliferation, adhesion, extracellular matrix (ECM)...
The microstructure, mechanical properties, <italic>in vitro</italic> degradation behavior, hemocompatibility and cytotoxicity were tested to investigate Zn–1.2Mg alloy as a new biodegradable material.
For large segmental bone defects, porous titanium scaffolds have some advantages, however, they lack electrical activity which hinders their further use. In this study, a barium titanate (BaTiO3) piezoelectric ceramic was used to modify the surface of Ti6Al4V scaffold (pTi), characterized by scanning electron microscopy, energy dispersive spectroscopy, X-ray photoelectron and roughness water contact angle analyses. Low intensity pulsed ultrasound (LIPUS) applied in vitro vivo study. The...
Bone defect repair at load-bearing sites is a challenging clinical problem for orthopedists. Defect reconstruction with implants the most common treatment; however, it requires implant to have good mechanical properties and capacity promote bone formation. In recent years, piezoelectric effect, in which electrical activity can be generated due deformation, of native bone, promotes formation, has been increasingly valued. Therefore, effects also attracted great attention from this study, we...
Increasing evidence suggests that traditional Chinese medicine strategies are obviously beneficial for cancer treatment, but scientific research on the underlying molecular mechanisms is lacking. We report ursolic acid, a bioactive ingredient isolated from Radix Actinidiae chinensis, has strong antitumour effects osteosarcoma cells. Functional studies showed acid inhibited tumour cell proliferation and promoted apoptosis of variety Ursolic had synergistic cytotoxic effect with cisplatin In...
Background The mismatch of the elastic modulus between implants and bone tissue can lead to stress shielding, resorption poor osseointegration. Compared with normal tissue, this problem is much more serious in osteoporosis. purpose study was designed find out whether novel Ti-24Nb-4Zr-7.9Sn (TNZS) implant low high strength suitable for biomedical material, especially Methodology In vitro study, viability Alkaline phosphatase (ALP) activity osteoblasts on TNZS Ti-6V-4V (TAV) were observed....
A HA-nanorod-patterned coating modulates the immune microenvironment to enhance contact osteogenesis and maintain long-term<italic>in vivo</italic>integrity of Mg.
Previous studies have found that the novel low-elastic-modulus Ti2448 alloy can significantly reduce stress shielding and contribute to better bone repair than conventional Ti6Al4V alloy. In this study, promotion of osteogenesis angiogenesis by three-dimensionally printed were also observed in vivo. However, these not significant a series vitro tests. The stiffness materials has been reported greatly affect response macrophages, immunological regulation mediated macrophages directly...
Abstract Neuroinflammation is associated with poor outcomes in patients spinal cord injury (SCI). Recent studies have demonstrated that stimulator of interferon genes (Sting) plays a key role inflammatory diseases. However, the Sting SCI remains unclear. In present study, it found increased expression mainly derived from activated microglia after SCI. Interestingly, knockout can improve recovery neurological function Microglial restrains polarization toward M1 phenotype and alleviates...
Background: The purpose of this study was to determine the risk factors for an unsuccessful replanted fingertip. Methods: Two hundred eleven complete fingertip amputations in 211 patients who underwent replantation surgery between August 1990 and March 2006 were included study. patients' age, gender, smoking history, digit position, dominant hand, amputation level, injury mechanism, platelet count, ischemia time, preservation method amputated part, anesthesia, number arteries repaired,...
Titanium and its alloys with various porous structures are one of the most important metals used in orthopaedic implants due to favourable properties as replacement for hard tissues. However, surface modification is critical improve osteointegration titanium alloys. In this study, a bioactive magnesium coating was successfully fabricated on Ti6Al4V by means arc ion plating, which proved fine grain size high film/substrate adhesion. The composition morphology were characterized X-ray...
The aim of this investigation was to study nonuniform corrosion in the vertical direction Q345 steel South China Sea. First, a metal monitoring system designed and applied based on coulometer principle array electrode technology. Then, through testing, weightlessness analysis, electrochemical surface morphology observation, behavior used an offshore wind turbine Zhanjiang Bay Sea studied. results revealed that within first 30 days experiment, electrodes connected by electricity exhibited...