A5034543981- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Retinal Development and Disorders
- Nuclear Receptors and Signaling
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Autophagy in Disease and Therapy
- Spine and Intervertebral Disc Pathology
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Nerve injury and regeneration
- Intensive Care Unit Cognitive Disorders
- Music Technology and Sound Studies
- Dementia and Cognitive Impairment Research
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Photoreceptor and optogenetics research
- Muscle Physiology and Disorders
- Ubiquitin and proteasome pathways
- Music and Audio Processing
Zhejiang University
2017-2025
Sir Run Run Shaw Hospital
2020-2025
Tongji University
2017-2024
Tongji Hospital
2017-2024
Huazhong University of Science and Technology
2021-2024
Air Force Medical University
2000-2024
Capital Medical University
2023
Duke University
2023
First Affiliated Hospital of Zhengzhou University
2022-2023
Ningbo Institute of Industrial Technology
2023
Abstract It is well-known that dead and dying neurons are quickly removed through phagocytosis by the brain’s macrophages, microglia. Therefore, neuronal loss during brain inflammation has always been assumed to be due of subsequent their apoptotic or necrotic death. However, we report in this article under inflammatory conditions primary rat cultures glia, actively induces Specifically, two bacterial ligands, lipoteichoic acid LPS (agonists glial TLR2 TLR4, respectively), stimulated...
Background: Postoperative delirium is common in older adult patients and associated with a poor prognosis. The use of benzodiazepine was identified as an independent risk factor for delirium, but there no randomized controlled trial regarding the relationship between remimazolam, new ultra-short acting benzodiazepine, postoperative delirium. We designed to evaluate if remimazolam increases incidence compared propofol undergoing orthopedic surgery general anesthesia. Patients Methods:...
Abstract Neurovascular coupling (NVC) is important for brain function and its dysfunction underlies many neuropathologies. Although cell-type specificity has been implicated in NVC, how active neural information conveyed to the targeted arterioles remains poorly understood. Here, using two-photon focal optogenetics mouse cerebral cortex, we demonstrate that single glutamatergic axons dilate their innervating via synaptic-like transmission between neural–arteriolar smooth muscle cell...
Milk-fat globule EGF factor-8 (MFG-E8, SED1, lactadherin) is known to mediate the phagocytic removal of apoptotic cells by bridging phosphatidylserine (PS)-exposing and vitronectin receptor (VR) on phagocytes. However, we show here that MFG-E8 can phagocytosis viable neurons during neuroinflammation induced lipopolysaccharide (LPS), thereby causing neuronal death. In vitro , inflammatory loss independent pathways, inhibited blocking PS/MFG-E8/VR pathway (by adding PS antibodies, annexin V,...
Background and Purpose Shikonin was reported to induce necroptosis in leukemia cells, but apoptosis glioma cell lines. Thus, it is needed clarify whether shikonin could cause cells investigate its underlying mechanisms. Methods rat C6 line Human U87 were used this study. The cellular viability assayed by MTT. Flow cytometry with annexin V-FITC PI double staining analyze death modes. Morphological alterations treated shikoinin evaluated electronic transmission microscopy fluorescence Hoechst...
Abstract The age-dependent decline in remyelination potential of the central nervous system during ageing is associated with a declined differentiation capacity oligodendrocyte progenitor cells (OPCs). molecular players that can enhance OPC or rejuvenate OPCs are unclear. Here we show that, mouse OPCs, nuclear entry SIRT2 impaired and NAD + levels reduced ageing. When supplement β-nicotinamide mononucleotide (β-NMN), an precursor, differentiation, were rescued aged animals. We effects on...
Abstract Background Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons in substantia nigra (SN). Microglia-mediated neuroinflammation has been largely considered one main factors to PD pathology. MicroRNA-218-5p (miR-218-5p) microRNA that plays role neurodevelopment and function, while its potential function remains unclear. Methods We explore involvement miR-218-5p 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse...
Hepcidin is a peptide hormone belonging to the defensin family of cationic antimicrobial molecules that has an essential role in systemic iron homeostasis. The synthesised by hepatocytes and transported circulation target tissues where it regulates export function ferrous permease, ferroportin. In brain hepcidin protein been identified using immuno-histochemistry mRNA real-time PCR but not situ hybridisation raising question whether there measurable transcription gene central nervous system....
Abstract Neuroinflammation is associated with poor outcomes in patients spinal cord injury (SCI). Recent studies have demonstrated that stimulator of interferon genes (Sting) plays a key role inflammatory diseases. However, the Sting SCI remains unclear. In present study, it found increased expression mainly derived from activated microglia after SCI. Interestingly, knockout can improve recovery neurological function Microglial restrains polarization toward M1 phenotype and alleviates...
Abstract As a major neuron type in the brain, excitatory (EN) regulates lifespan C. elegans. How EN acquires senescence, however, is unknown. Here, we show that growth differentiation factor 11 (GDF11) predominantly expressed adult mouse, marmoset and human brain. In mice, selective knock-out of GDF11 post-mitotic shapes brain ageing-related transcriptional profile, induces senescence hyperexcitability, prunes their dendrites, impedes synaptic input, impairs object recognition memory...
Abstract Brain injury induces gliosis and scar formation; its principal cell types are mainly astrocytes some oligodendrocytes. The origin of the oligodendrocytes in remains unclear together with underlying mechanism their fate choice. We examined response oligodendrocyte transcription factor (Olig)2 + glial progenitors to acute brain injury. Both focal cortical (mechanical or excitotoxic) systemic (kainic acid‐induced seizure lipopolysaccharide‐induced inflammation) caused cytoplasmic...
Parkinson's disease (PD) is a common neurodegenerative and difficult to treat due its elusive mechanisms. Recent studies have identified striking association between oligodendrocytes PD progression, yet how regulate the pathogenesis of still unknown. Here, we show that G-protein-coupled receptor 37 (GPR37) upregulated in substantia nigra prosaposin (PSAP) secretion increased parkinsonian mice. The released PSAP can induce interleukin (IL)-6 upregulation from via GPR37-dependent pathway,...
Osteosarcoma is the most frequent type of malignant primary bone tumor. Although many efforts have been made, survival rate osteosarcoma still remains unsatisfied. Long non-coding RNAs (lncRNAs) demonstrated to be associated with diseases including tumors, and involved in regulation a wide array pathophysiological processes. Colon-cancer-associated transcript-1 (CCAT1) was first identified colon cancer has subsequently reported perform functions tumor progression. The present study aimed...
A group of circulating microRNAs (miRNAs) have been implicated in the pathogenesis Parkinson’s disease. However, a comprehensive study interactions between pathogenic miRNAs and their downstream disease (PD)-related target genes has not performed. Here, we identified miRNA expression profiles plasma exosomes patients using next-generation RNA sequencing. Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology (GO) analyses showed that were enriched axon guidance, neurotrophin signaling,...
At a time of striving for CO2-free power, NH3 becomes potential energy storage carrier fuel from renewable sources. The reaction molecular dynamics (ReaxFF-MD) method was used to study the effect CH4 reactivity on oxidation in an O2/N2 environment. conversion process combustion intermediates is explored. Under fuel-rich, stoichiometric, and fuel-lean conditions, at temperature 2400–3200 K, mixed with different concentration ratios simulated. Studies have found that ammonia methane are not...